{"id":43,"date":"2019-06-27T03:49:11","date_gmt":"2019-06-27T09:19:11","guid":{"rendered":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/?page_id=43"},"modified":"2020-03-24T12:15:02","modified_gmt":"2020-03-24T17:45:02","slug":"research","status":"publish","type":"page","link":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p>[vc_row][vc_column][vc_custom_heading text=&#8221;Research&#8221; font_container=&#8221;tag:h2|text_align:left|line_height:1.5&#8243; google_fonts=&#8221;font_family:Adamina%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221;][vc_separator][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1535953458083{padding-top: 0px !important;padding-bottom: 0px !important;}&#8221;][vc_column][vc_empty_space]<h3 class=\"fac-title text-left\" style=\"color:#4b4b4b\">Undergraduate Research projects \u2013 2018<\/h3>\n[vc_column_text]<\/p>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<ul class=\"ul-boxed list-unstyled\">\n<li><strong>In search of wood rotting enzymes from macro-fungi.<\/strong><br \/>\nStudent name &#8211; A.M.Erandi<br \/>\nSupervisor(s) &#8211; Dr.Chandrika.M.Nanayakkara, Dr.N.V.Chandrasekaran<br \/>\nTopic overview &#8211; Macro fungi fruit bodies will be collected from selected forest patch. Identification is done using classical (morphology) and molecular methods. Molecular method is based on amplifying and sequencing ITS (internal transcibed spacer) region to identify species level. The pure cultures produced will be screened for industrial important enzymes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<ul class=\"ul-boxed list-unstyled\">\n<li><strong>Determining the genetic basis for thyroid hormone resistance among suspected cases in Sri Lanka.<\/strong><br \/>\nStudent name &#8211; R.Varsha<br \/>\nSupervisor(s) &#8211; Prof. Deepthi de Silva, Dr. Gayathri Silva<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<ul class=\"ul-boxed list-unstyled\">\n<li><strong>Normal distribution of Methylene tertrahydrofolate Reductase polymorphisms in the Sri Lankan population.<\/strong><br \/>\nStudent name &#8211; H.A.A.Harshani<br \/>\nSupervisor(s) &#8211; Prof. Deepthi de Silva, Dr. Gayathri Silva<br \/>\nTopic overview &#8211; Collected blood samples of normal people in Sri Lankan population belong to main ethnic groups are subjected to DNA extraction and polymerase chain reaction using high resolution melt technique to find polymorphisms related to methylenetetrahydrofolate reductase deficiency. And statistically evaluate the normal distribution of methylenetetrahydrofolate reductase polymorphisms in different ethnic groups in Sri Lankan population.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<ul class=\"ul-boxed list-unstyled\">\n<li><strong>Characterization of T1 transgenic tomato plants for the presence of 16D10 parasitism gene.<\/strong>Student name &#8211; W.L.D.S.Maleesha<br \/>\nSupervisor(s) &#8211; Dr.Chamari Hettiarachchi, Prof.R.S.Dassanayake,Ms.U.Rajapakse<br \/>\nTopic overview -Characterization of transgenic tomato plants for the presence of 16D10 nematode parasitism gene &amp; qualitative and quantitative analysis of transcript abundance via qPCR and southern blotting. With the aim of establishing da effect of HIGS on the lowered infection rate of roots by the RKN.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<ul class=\"ul-boxed list-unstyled\">\n<li><strong>Designing and validation of a novel transgenic DNA cassette construction to transfect in Zebrafish: Toward a Zebrafish biosensor for heavy metal water contamination detection.<\/strong>Student name &#8211; J.R.P.Jayasinghe<br \/>\nSupervisor(s) &#8211; Prof. R.S.Dassanayake, Prof.Y.I.N.S.Gunawardena,Dr.R.de Silva,Prof.K.M.N.de Silva.<br \/>\nTopic overview -We have to design a novel transgenic DNA cassette construction with a heavy metal sensitive promoter which should be microinjected into both wild type and transparent mutant fish and validate with behavioral and molecular assays. Project ultimate goal is to generate a reliable, cost effective and real-time detection method to appraise the bio available level of heavy metal in Sri Lankan water reservoirs by using the ability of transgenic fish to produce measurable signals when in contact with the heavy metal.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_custom_heading text=&#8221;Research&#8221; font_container=&#8221;tag:h2|text_align:left|line_height:1.5&#8243; google_fonts=&#8221;font_family:Adamina%3Aregular|font_style:400%20regular%3A400%3Anormal&#8221;][vc_separator][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1535953458083{padding-top: 0px !important;padding-bottom: 0px !important;}&#8221;][vc_column][vc_empty_space][vc_column_text] In search of wood rotting enzymes from macro-fungi. Student name &#8211; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-pagebuilder.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/pages\/43"}],"collection":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/comments?post=43"}],"version-history":[{"count":17,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/pages\/43\/revisions"}],"predecessor-version":[{"id":389,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/pages\/43\/revisions\/389"}],"wp:attachment":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/btec\/wp-json\/wp\/v2\/media?parent=43"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}