{"id":19,"date":"2022-01-13T05:24:14","date_gmt":"2022-01-13T05:24:14","guid":{"rendered":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/?page_id=19"},"modified":"2026-02-23T20:53:46","modified_gmt":"2026-02-23T15:23:46","slug":"research","status":"publish","type":"page","link":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p><strong><span style=\"color: #0000ff\">Core Research Areas<\/span><\/strong><\/p>\n<ol data-start=\"111\" data-end=\"2537\">\n<li data-start=\"111\" data-end=\"441\">\n<p data-start=\"114\" data-end=\"441\"><strong data-start=\"114\" data-end=\"192\">Bioactivity-Guided Natural Product Discovery\u00a0<\/strong><br data-start=\"192\" data-end=\"195\" \/>Systematic bioactivity-guided fractionation, advanced extraction technologies, and integrated purification strategies for the identification, structural elucidation, and pharmacological validation of therapeutically relevant natural compounds.<\/p>\n<\/li>\n<li data-start=\"443\" data-end=\"745\">\n<p data-start=\"446\" data-end=\"745\"><strong data-start=\"446\" data-end=\"523\">Chemical and Pharmacological Characterisation of Natural Immunomodulators<\/strong><br data-start=\"523\" data-end=\"526\" \/>Comprehensive chemical, biochemical, and cellular evaluation of natural bioactives targeting respiratory inflammatory disorders, with particular emphasis on epithelial-derived cytokine pathways and immune modulation.<\/p>\n<\/li>\n<li data-start=\"747\" data-end=\"1016\">\n<p data-start=\"750\" data-end=\"1016\"><strong data-start=\"750\" data-end=\"828\">Mechanism-Driven Drug Repurposing Targeting Epithelial Cytokine Signalling<\/strong><br data-start=\"828\" data-end=\"831\" \/>Rational screening and mechanistic assessment of repurposed drug candidates as antagonists of epithelial cytokines implicated in airway inflammation and chronic respiratory diseases.<\/p>\n<\/li>\n<li data-start=\"1018\" data-end=\"1390\">\n<p data-start=\"1021\" data-end=\"1390\"><strong data-start=\"1021\" data-end=\"1112\">Molecular Mechanisms of Anti-Aging and Phytocosmeceutical Potential of Natural Products<\/strong><br data-start=\"1112\" data-end=\"1115\" \/>Investigation of cellular and molecular pathways underlying skin aging, including oxidative stress, inflammation, extracellular matrix degradation, and epigenetic modulation, alongside evaluation of natural compounds for phytocosmeceutical and dermatological applications.<\/p>\n<\/li>\n<li data-start=\"1392\" data-end=\"1707\">\n<p data-start=\"1395\" data-end=\"1707\"><strong data-start=\"1395\" data-end=\"1459\">Advanced Stabilisation Platforms for Labile Natural Products<\/strong><br data-start=\"1459\" data-end=\"1462\" \/>Design and optimisation of physicochemical stabilisation systems to enhance stability, bioavailability, and therapeutic performance of volatile and structurally sensitive natural compounds for pharmaceutical and aromatherapeutic applications.<\/p>\n<\/li>\n<li data-start=\"1709\" data-end=\"2004\">\n<p data-start=\"1712\" data-end=\"2004\"><strong data-start=\"1712\" data-end=\"1794\">Advanced Colloidal and Structured carrier Systems for Natural Bioactives<\/strong><br data-start=\"1794\" data-end=\"1797\" \/>Development of emulsion-based and structured colloidal carrier platforms to enhance solubility, membrane permeability, controlled release behaviour, and targeted therapeutic efficacy of natural compounds.<\/p>\n<\/li>\n<li data-start=\"2006\" data-end=\"2238\">\n<p data-start=\"2009\" data-end=\"2238\"><strong data-start=\"2009\" data-end=\"2072\">Modified Starch Systems for Regulated Drug Release Kinetics<\/strong><br data-start=\"2072\" data-end=\"2075\" \/>Exploration and functional modification of starch-based polymers to achieve controlled, responsive, and optimised release profiles for therapeutic applications.<\/p>\n<\/li>\n<li data-start=\"2240\" data-end=\"2537\">\n<p data-start=\"2243\" data-end=\"2537\"><strong data-start=\"2243\" data-end=\"2317\">Value Addition to Agricultural Waste for Bioactive Product Development<\/strong><br data-start=\"2317\" data-end=\"2320\" \/>Integration of green extraction, purification, and formulation strategies to convert agricultural by-products into high-value bioactive materials supporting innovative pharmaceutical and cosmeceutical applications.<\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Google Scholar: https:\/\/scholar.google.com\/citations?user=SyTDi5oAAAAJ&amp;hl=en<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Core Research Areas Bioactivity-Guided Natural Product Discovery\u00a0Systematic bioactivity-guided fractionation, advanced extraction technologies, and integrated purification strategies for the identification, structural [&hellip;]<\/p>\n","protected":false},"author":45,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/pages\/19"}],"collection":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/users\/45"}],"replies":[{"embeddable":true,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/comments?post=19"}],"version-history":[{"count":4,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/pages\/19\/revisions"}],"predecessor-version":[{"id":139,"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/pages\/19\/revisions\/139"}],"wp:attachment":[{"href":"https:\/\/www.res.cmb.ac.lk\/chemistry\/sachindra-perera\/wp-json\/wp\/v2\/media?parent=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}