Book
A Comparative study of Polycystic Ovary Syndrome (PCOS) amongst caucasian South Asian women
Description
Polycystic ovaries are reported to be commoner in British Asians than among white Europeans. Insulin resistance (IR) is central to the pathogenesis of PCOS. Type 2 diabetes is commoner in South Asians.
Objective:
To determine any ethic difference in clinical, biochemical and selected genetic characteristics of PCOS in South Asians versus Caucasians. Patients and
Design:
Cross-sectional observational study of consecutive women with PCOS; UK based-47 British Asian (BA), 40 Caucasian c women with PCOS and controls; 11 BA and 22C; Sri Lanka based-80 Lankan women with PCOS (SL) and 45 controls.
Methods:
Clinical symptoms, anthropometric measurements, degree of acne, hirsutism and acanthosis nigricans; fasting blood glucose, plasma insulin, lipids, testosterone, and sex hormone binding globulin (SHBG), homocysteine, inhibin B and follistatin; DNA analysis for polymorphisms of Insulin VNTR of all subjects and FSH á gene in the British subjects were performed. Controls Unrelated women without PCOS from matching ethnic background were studied at the same centres. Inter-laboratory biochemical correlation was performed.