Gamma radiation has been utilized to improve many genotypes of crop species with the primary goal of increasing genetic variation and using it in plant breeding. Hence considering this, an experiment was conducted in a CRD with four replicates at the University of Colombo Institute for Agro-technology and Rural Sciences, Hambantota, Sri Lanka, to evaluate the influence of gamma irradiation on the performances of Acalypha hispida. The rooted cuttings were subjected to various dosages of Co60 gamma irradiation, including 0, 20, 25, 30, 35, and 40 Gy. Treated plants were observed for its morphological changes and survival %, plant height, number of leaves and length of inflorescences were recorded. Collected data were statistically analyzed using ANOVA procedures by SAS 9.1.3 software package. Based on the present findings, no significant differences were observed in survival % and length of inflorescences. Further, early days of growth showed significance on plant height and number of leaves. The increase in dose decreased the plant height and number of leaves. Later days of plant growth, no significance was observed in measured growth variables. Changes in leaf shapes were noticed during the early stage of growth and later the pattern changed into normal. Plants treated with 30 Gy and above showed colour changes (pink and white) in inflorescences which persisted as its continuing general character. It can be stated that, variation in vegetative parts (leaves) was recovered and variations in inflorescences continued during its growth and development. Treating the A. hispida plants with gamma irradiation has the potential to create variation in plants and it can be suggested to apply more gamma irradiation stress (>40 Gy) on A. hispida to induce more variations.