Dr. Sisira Lal Pathirana
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
Evidence for strain-specific protective immunity against blood-stage parasites of Plasmodium cynomolgi in toque monkey
Wijayalath WAWK, Cheesman S, Rajakaruna J, Handunnetti SM, Carter R, Pathirana P P S L. Evidence for strain-specific protective immunity against blood-stage parasites of Plasmodium cynomolgi in toque monkey. Parasite Immunology. 2008:30;630-636. DOI: 10.1111/j.1365-3024.2008.01065.x
Dynamics of host immunity in relation to Plasmodium cynomolgi relapse infections in toque monkey (Macaca sinica)
Jayawardena KH, Sooriya Arachchi NN, Wijayalath WAWK, Pathirana PPSL. Dynamics of host immunity in relation to Plasmodium cynomolgi relapse infections in toque monkey (Macaca sinica). Fifth Annual Academic Sessions, The Open University of Sri Lanka 2008; 102-104
Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites
Tanabe K, Escalante A, Sakihama N, Honda M, Arisue N, Horii T, Culloton R, Hayakawa T, Hashimoto T, Longacre S, Pathirana S, Handunnetti S, Kishino H. Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites. Mol. Biochem. Parasitol. 2007:156; 74-79. doi:10.1016/j.molbiopara.2007.07.002
Studies on strain-specific protective immunity in malaria using Plasmodium cynomolgi/ Macaca sinica model
WAWK Wijayalath, S Cheesman, J Rajakaruna, K Gamage, K Perera, KLRL Perera, R Carter, SM Handunnetti, PPSL Pathirana. 2006. Studies on strain-specific protective immunity in malaria using Plasmodium cynomolgi/ Macaca sinica model. Proceedings of the 3rd Annual Academic Sessions of the Allergy and Immunology Society of Sri Lanka, November 2006, B1, page 24.
Cytoadherence of Plasmodium falciparum Sri Lankan parasite isolates to human endothelial receptors at two different temperatures
Varuni Munasinghe, Inoka Perera, Sisira Pathirana, Wathsala Wijayalath, Anjanie Munasinghe, Dulip Gunasekara and Sunil Premawansa. Cytoadherence of Plasmodium falciparum Sri Lankan parasite isolates to human endothelial receptors at two different temperatures. Proceedings of the 25th Annual Academic Sessions of the Institute of Biology, Sri Lanka. 2005
Agglutination properties of Plasmodium falciparum parasites and their associations with cytoadherence and disease severity
D C S Gunasekara, P P S L Pathirana, I C Perera, R A Munasinghe, M G M Kapilananda, S Premawansa. 2005. Agglutination properties of Plasmodium falciparum parasites and their associations with cytoadherence and disease severity. Proceedings of the 25th Annual Academic Sessions of the Institute of Biology, Sri Lanka. 2005, 33.
ABO blood group types and protection against severe Plasmodium falciparum malaria. Annals of Tropical Medicine and Parasitology
Pathirana S L, Alles H K, Perera M K, Bandara S, Phone-Kyaw M, Mendis K N and Handunnetti S M. ABO blood group types and protection against severe Plasmodium falciparum malaria. Annals of Tropical Medicine and Parasitology 2005:99 (2);119-124(6). DOI: http://dx.doi.org/10.1179/136485905X19946
Studies on genetic composition of primary and relapse parasites of Plasmodium cynomolgi infections
W A W K Wijayalath, J Rajakaruna, K Gamage, K Perera, K L R L Perera, C Ameratunga, N Sakihama, K Tanabe, S Cheesman, R Carter, S M Handunnetti and P P S L Pathirana. Studies on genetic composition of primary and relapse parasites of Plasmodium cynomolgi infections. Proceedings of the 2nd Annual Sessions of Allergy and Immunology Society of Sri Lanka. 2004, B-2.
Inhibitory effects on parasite cytoadherence by sera from Plasmodium falciparum infected Sri Lankan patients
I C Perera, P P S L Pathirana, G M Kapilananda, R A Munasinghe, S M Handunnetti and S Premawansa. Inhibitory effects on parasite cytoadherence by sera from Plasmodium falciparum infected Sri Lankan patients. Proceedings of the Sri Lanka Association for the Advancement of Science.2004, Page 28.
Immunogenecity and protective efficacy of two new vaccine formulations based on MSP1-P19 of Plasmodium cynomolgi
S M Handunnetti, S Weerasinghe, C Ameratunga, S L Pathirana, J Rajakaruna, K L R L Perera, K Gamage, K Perera, I Holm, and S Longacre. Immunogenecity and protective efficacy of two new vaccine formulations based on MSP1-P19 of Plasmodium cynomolgi. Proceedings of the Joint Academic Sessions, Faculties of Science and Medicine of the University of Colombo. 2004, Page 15.
Development of Real Time Quantitative PCR (RTQ PCR) method for analysis of vaccine protection using Plasmodium cynomolgi malaria model
P P S L Pathirana, Liselotte Walters, Sudath Weerasinghe, Shirly Longacre, Robert Sauerwein, Shiroma Handunnetti and C C Hermsen. Development of Real Time Quantitative PCR (RTQ PCR) method for analysis of vaccine protection using Plasmodium cynomolgi malaria model. Proceedings of the Joint Academic Sessions, Faculties of Science and Medicine of the University of Colombo. 2004, Page 16.
Development of Real Time Quantitative PCR (RTQ PCR) method for analysis of vaccine protection using Plasmodium cynomolgi malaria model
P P S L Pathirana, Liselotte Walters, Sudath Weerasinghe, Shirly Longacre, Robert Sauerwein, Shiroma Handunnetti and C C Hermsen. Development of Real Time Quantitative PCR (RTQ PCR) method for analysis of vaccine protection using Plasmodium cynomolgi malaria model. Proceedings of the 2nd Annual Sessions of Allergy and Immunology Society of Sri Lanka. 2004, B-3.
Cytoadherence and its inhibition of Plasmodium falciparum parasites from Sri Lankan patients to human endothelial receptors of CD36 and ICAM-1
I. C. Perera, R.A. Munasinghe, S. Pathirana, M. K. Perera, M. Ileperuma, T. Nadaraja, G. M. Kapilananda, G. Premawansa, S. M. Handunnetti and S. Premawansa. Cytoadherence and its inhibition of Plasmodium falciparum parasites from Sri Lankan patients to human endothelial receptors of CD36 and ICAM-1. Proceedings of the 2nd Annual Academic Sessions of the Allergy and Immunology Society of Sri Lanka, November 2004, B-8.
Are relapse infections of Plasmodium cynomolgi, clones of primary infections?
W A W K Wijayalath, J Rajakaruna, K Gamage, K Perera, K L R L Perera, C Ameratunga, N Sakihama, K Tanabe, S Cheesman, R Carter, S M Handunnetti and P P S L Pathirana. Are relapse infections of Plasmodium cynomolgi, clones of primary infections? Proceedings of the Joint Academic Sessions, Faculties of Science and Medicine of the University of Colombo. 2004, Page 23.
Numerous, robust genetic markers for Plasmodium chabaudi by the method of Amplified Fragment Length Polymorphism
Grech K, Martinelli A, Pathirana S, Walliker D, Hunt P & Carter R. Numerous, robust genetic markers for Plasmodium chabaudi by the method of Amplified Fragment Length Polymorphism. Mol. Biochem. Parasitol. 2002:123;95-104. doi:10.1016/S0166-6851(02)00142-1
Auto-agglutination abilities of Plasmodium falciparum parasite isolates from severe complicated and uncomplicated P. falciparum infections
R A Munasinghe, P P S L Pathirana, S A A Jagadeesh, M Ileperuma, K L R L Perera, S M Handunnetti, S Premawansa. Auto-agglutination abilities of Plasmodium falciparum parasite isolates from severe complicated and uncomplicated P. falciparum infections. Proceedings of the Sri Lanka Association for the Advancement of Science. 2001, 57:18.
Molecular markers to identify genes, which code targets of strain-specific protective immunity in Plasmodium chabaudi
Sisira Pathirana, Katrina Grech and Richard Carter. Molecular markers to identify genes, which code targets of strain-specific protective immunity in Plasmodium chabaudi. Proceedings of the Sri Lanka Association for the Advancement of Science. 2000, 56: 6.
Amplified fragment length polymorphisms (AFLP) to construct a high-resolution genetic linkage map in Plasmodium chabaudi
K Grech, A Martinelli, S Pathirana, P Hunt and R Carter (2000). Amplified fragment length polymorphisms (AFLP) to construct a high-resolution genetic linkage map in Plasmodium chabaudi. Proceedings of the New challenges in tropical medicine and Parasitology (Oxford 2000, a joint meeting organized by The Royal Society of Tropical Medicine and Hygiene, British Society for Parasitology and The American Society of Tropical Medicine and Hygiene). pp 120.
Molecular markers to identify strain-specific targets of protective immunity in Plasmodium chabaudi
Sisira Pathirana, Katrina Grech and Richard Carter (1999). Molecular markers to identify strain-specific targets of protective immunity in Plasmodium chabaudi. Annual Meeting of the Scottish Universities Molecular Parasitologists (SUMP VII). Kindrogan, Scotland (Abstract 9).
Plasma cytokine levels in severe-complicated Plasmodium falciparum malaria
M K Perera, S D Abeynayake, M Phone-Kyaw, S Bandara, H Alles, N Fernando, C Wimalesena, S L Pathirana, S Premawansa, Kamini Mendis, S M Handunnetti. Plasma cytokine levels in severe-complicated Plasmodium falciparum malaria. Proceedings of the Sri Lanka Association for the Advancement of Science. 1998, 54: 32
Association between ABO blood groups and protection against severe and complicated Plasmodium falciparum malaria
Pathirana P P S L, Alles H K, Perera M K, Mendis K N and Handunnetti S M (1997). Association between ABO blood groups and protection against severe and complicated Plasmodium falciparum malaria. Proceedings of the 2nd Global Meet on Parasitic Diseases. Hyderabad, India. pp187-188 .
Association between ABO blood groups and disease severity in Plasmodium falciparum malaria
Pathirana P P S L, Alles H K, Perera M K, Myat Phone-Kyaw, Ekenayake K, Bandara S, Wijesinhe U, Somatileke D, Wimalasena C, Abeynayake S, Mendis K N and Handunnetti S M. Association between ABO blood groups and disease severity in Plasmodium falciparum malaria. Proceedings of the Sri Lanka Association for the Advancement of Science. 1997, 53: 6.
Adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1: A marker of parasite virulence.
Handunnetti S M, Pathirana P P S L, Howard R J, Mendis K N (1997). Adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1: A marker of parasite virulence. Proceedings of the 2nd Global Meet on Parasitic Diseases. Hyderabad, India. pp 213-214.
Regulation of adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1 by plasma from cerebral malaria patients
Pathirana P P S L, Ekenayake K, Alles H K, Bandara S, Mendis K N and Handunnetti S M. Regulation of adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1 by plasma from cerebral malaria patients. Proceedings of the Sri Lanka Association for the Advancement of Science. 1996, 52: 25-26.
Recrudescent chloroquine-resistant Plasmodium falciparum parasites have a survival advantage
Handunnetti S M, Mendis K N, Gunewardena D M, Pathirana P P S L (1996). Recrudescent chloroquine-resistant Plasmodium falciparum parasites have a survival advantage. XIV International congress for Tropical Medicine and Malaria, Nagasaki, Japan. Pp169, O-07.
Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites, and have implications for disease control
Handunnetti S M, Gunawardena D M, Pathirana P P S L, Ekenayake K, Weerasinghe S and Mendis K N. Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites, and have implications for disease control. Transactions of the Royal Society of Tropical Medicine and Hygiene1996:90;563-567. doi: 10.1016/S0035-9203(96)90325-9
Cytoadherence properties of Plasmodium falciparum-infected erythrocytes in relation to severity of clinical disease and parasite density in uncomplicated malaria in Sri Lanka
Pathirana P P S L, Ekenayake K, Mendis K N and Handunnetti S M. Cytoadherence properties of Plasmodium falciparum-infected erythrocytes in relation to severity of clinical disease and parasite density in uncomplicated malaria in Sri Lanka. Proceedings of the Sri Lanka Association for the Advancement of Science. 1996, 52: 26
Malaria parasite goes into hiding-inside you
Alles HK, Silva D de, Naotunne TDS, Pathirana PPSL, Jayasinghe S. Joint study by these authors was published under the title “Malaria parasite goes into hiding-inside you” in “Daily News”, December 28, 1994.
Enhancement of cytoadherence of Plasmodium falciparum-infected erythrocytes to CD36 by malarial paroxysm plasma
Pathirana P P S L, Ekenayake K, Weerasinhe S, Alles H K, Carter R, Mendis K N, Handunnetti S M. Enhancement of cytoadherence of Plasmodium falciparum-infected erythrocytes to CD36 by malarial paroxysm plasma. Proceedings of the Sri Lanka association for the Advancement of Science. 1994, 50: 24
Chloroquine and sulphadoxine pyrimethamine resistant Plasmodium falciparum infection in Sri Lanka
Handunnetti S M, Jayasinghe S, Pathirana P P S L, Fernando R, Sheriff M H R, and Mendis K N. Chloroquine and sulphadoxine pyrimethamine resistant Plasmodium falciparum infection in Sri Lanka. Ceylon Medical Journal 1994:39;45 46. PMID:8194148