Dr. E. P. Meran Keshawa
Research Articles
Publication Types:
Odd-chain fatty acids as novel histone deacetylase 6 (HDAC6) inhibitors.
Research Articles
Ediriweera MK, To NB, Lim Y, Cho SK. Odd-chain fatty acids as novel histone deacetylase 6 (HDAC6) inhibitors. Biochimie. 2021 Jul 1;186:147-56.
Publication year: 2021
Metal-Amino Acid Nanofibers based Triboelectric Nanogenerator for Self-Powered Thioacetamide Sensor
Research Articles
Khandelwal G, Ediriweera MK, Kumari N, Maria Joseph Raj NP, Cho SK, Kim SJ. Metal-Amino Acid Nanofibers based Triboelectric Nanogenerator for Self-Powered Thioacetamide Sensor. ACS Applied Materials & Interfaces. 2021 Apr 19;13(16):18887-96.
Publication year: 2021
Identification of 3-O-α-l-arabinosyl oleanolic acid, a triterpenoid saponin, as a new breast cancer stem cell growth inhibitor.
Research Articles
Muthoni DK, Samarakoon SR, Piyathilaka PC, Rajagopalan U, Tennekoon KH, Ediriweera MK. Identification of 3-O-α-l-arabinosyl oleanolic acid, a triterpenoid saponin, as a new breast cancer stem cell growth inhibitor. Natural Product Research. 2021 May 23:1-4.
Publication year: 2021
Effects of Cooking and Processing Methods on Phenolic Contents and Antioxidant and Anti-Proliferative Activities of Broccoli Florets.
Research Articles
Kim HY, Ediriweera MK, Boo KH, Kim CS, Cho SK. Effects of Cooking and Processing Methods on Phenolic Contents and Antioxidant and Anti-Proliferative Activities of Broccoli Florets. Antioxidants. 2021 May;10(5):641.
Publication year: 2021
Development of a New Nanocarrier for Dietary Garcinol: Characterization and In Vitro Efficacy Evaluation Using Breast Cancer Stem Cells Grown in Hypoxia.
Research Articles
Hulangamuwa AC, Ediriweera MK, Rajagopalan U, Karunaratne DN, Tennekoon KH, Samarakoon SR. Development of a New Nanocarrier for Dietary Garcinol: Characterization and In Vitro Efficacy Evaluation Using Breast Cancer Stem Cells Grown in Hypoxia. Journal of Food Quality. 2021 Feb 10;2021.
Publication year: 2021
Catechol enhances chemo‑and radio‑sensitivity by targeting AMPK/Hippo signaling in pancreatic cancer cells.
Research Articles
Moon JY, Ediriweera MK, Ryu JY, Kim HY, Cho SK. Catechol enhances chemo‑and radio‑sensitivity by targeting AMPK/Hippo signaling in pancreatic cancer cells. Oncology reports. 2021 Mar 1;45(3):1133-41.
Publication year: 2021
Phenethyl Isothiocyanate Suppresses Stemness in the Chemo-and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin.
Research Articles
Nguyen YT, Moon JY, Ediriweera MK, Cho SK. Phenethyl isothiocyanate suppresses stemness in the chemo-and radio-resistant triple-negative breast cancer cell line MDA-MB-231/IR via downregulation of metadherin. Cancers. 2020 Feb;12(2):268.
Publication year: 2020
Pentadecanoic Acid, an Odd-Chain Fatty Acid, Suppresses the Stemness of MCF-7/SC Human Breast Cancer Stem-Like Cells through JAK2/STAT3 Signaling.
Research Articles
To NB, Nguyen YT, Moon JY, Ediriweera MK, Cho SK. Pentadecanoic Acid, an Odd-Chain Fatty Acid, Suppresses the Stemness of MCF-7/SC Human Breast Cancer Stem-Like Cells through JAK2/STAT3 Signaling. Nutrients. 2020 Jun;12(6):1663.
Publication year: 2020
Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line MDA-MB-231.
Research Articles
Colamba Pathiranage V, Lowe JN, Rajagopalan U, Ediriweera MK, Senathilake K, Piyathilaka P, Tennekoon KH, Samarakoon SR. Hexane extract of Garcinia quaesita fruits induces apoptosis in breast cancer stem cells isolated from triple negative breast cancer cell line MDA-MB-231. Nutrition and Cancer. 2021 Mar 10;73(5):845-55.
Publication year: 2020
Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells
Research Articles
Pathiranage VC, Thabrew I, Samarakoon SR, Tennekoon KH, Rajagopalan U, Ediriweera MK. Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells. Journal of integrative medicine. 2020 May 1;18(3):242-52.
Publication year: 2020
Dietary flavonoid Myricetin inhibits invasion and migration of radioresistant lung cancer cells (A549‐IR) by suppressing MMP‐2 and MMP‐9 expressions through inhibition of the FAK‐ERK signaling pathway.
Research Articles
Kang HR, Moon JY, Ediriweera MK, Song YW, Cho M, Kasiviswanathan D, Cho SK. Dietary flavonoid myricetin inhibits invasion and migration of radioresistant lung cancer cells (A549‐IR) by suppressing MMP‐2 and MMP‐9 expressions through inhibition of the FAK‐ERK signaling pathway. Food science & nutrition. 2020 Apr;8(4):2059-67.
Publication year: 2020
10-Gingerol targets lipid rafts associated PI3K/Akt signaling in radio-resistant triple negative breast cancer cells
Research Articles
Ediriweera MK, Moon JY, Nguyen YT, Cho SK. 10-gingerol targets lipid rafts associated PI3K/Akt signaling in radio-resistant triple negative breast cancer cells. Molecules. 2020 Jan;25(14):3164.
Publication year: 2020
Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells.
Research Articles
Abeysinghe NK, Thabrew I, Samarakoon SR, Ediriweera MK, Tennekoon KH, Pathiranage VP, Mendis AS. Vernolactone promotes apoptosis and autophagy in human teratocarcinomal (NTERA-2) cancer stem-like cells. Stem cells international. 2019 Dec 19;2019.
Publication year: 2019
Targeting miRNAs by histone deacetylase inhibitors (HDACi): Rationalizing epigenetics-based therapies for breast cancer.
Research Articles
Ediriweera MK, Cho SK. Targeting miRNAs by histone deacetylase inhibitors (HDACi): Rationalizing epigenetics-based therapies for breast cancer. Pharmacology & therapeutics. 2020 Feb 1;206:107437.
Publication year: 2019
Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance
Research Articles
Ediriweera MK, Tennekoon KH, Samarakoon SR. Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. InSeminars in cancer biology 2019 Dec 1 (Vol. 59, pp. 147-160). Academic Press.
Publication year: 2019
In vitro assays and techniques utilized in anticancer drug discovery.
Research Articles
Ediriweera MK, Tennekoon KH, Samarakoon SR. In vitro assays and techniques utilized in anticancer drug discovery. Journal of Applied Toxicology. 2019 Jan;39(1):38-71.
Publication year: 2019
Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents. Drug discovery today.
Research Articles
Ediriweera MK, Tennekoon KH, Samarakoon SR. Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents. Drug discovery today. 2019 Mar 1;24(3):685-702.
Publication year: 2019
Annona squamosa L. leaves inhibit alpha‐melanocyte‐stimulating hormone (α‐MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells.
Research Articles
Ko GA, Kang HR, Moon JY, Ediriweera MK, Eum S, Bach TT, Cho SK. Annona squamosa L. leaves inhibit alpha‐melanocyte‐stimulating hormone (α‐MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells. Journal of cosmetic dermatology. 2020 Jul;19(7):1785-92.
Publication year: 2019
Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae).
Research Articles
Samarakoon SR, Ediriweera MK, Wijayabandara L, Fernando N, Tharmarajah L, Tennekoon KH, Piyathilaka P, Adhikari A. Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae). Tropical Journal of Pharmaceutical Research. 2018 May 9;17(3):475-81.
Publication year: 2018
Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines.
Research Articles
Mendis AS, Thabrew I, Ediriweera MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED. Isolation of a new sesquiterpene lactone from Vernonia zeylanica (L) Less and its anti-proliferative effects in breast cancer cell lines. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2019 Feb 1;19(3):410-24.
Publication year: 2018
Cytotoxic and Apoptotic Effects of Govaniadine Isolated from Corydalis govaniana Wall. Roots on Human Breast Cancer (MCF-7) Cells.
Research Articles
Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige N, Thabrew I, Shrestha RL. Cytotoxic and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall. roots on human breast cancer (MCF-7) Cells. BioMed research international. 2018 Jul 24;2018.
Publication year: 2018
Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves
Research Articles
Ediriweera MK, Jayarathna P, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, Adhikari A. Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves. Phytochemistry Letters. 2018 Apr 1;24:114-9.
Publication year: 2018
Protective effects of six selected dietary compounds against leptin-induced proliferation of oestrogen receptor positive (MCF-7) breast cancer cells.
Research Articles
Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, De Silva ED. Protective effects of six selected dietary compounds against leptin-induced proliferation of oestrogen receptor positive (MCF-7) breast cancer cells. Medicines. 2017 Sep;4(3):56.
Publication year: 2017
Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook. f. bark and its cytotoxic and apoptotic potential.
Research Articles
Ediriweera MK, Tennekoon KH, Samarakoon SR, Adhikari A, Thabrew I, De Silva ED. Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook. f. bark and its cytotoxic and apoptotic potential. Biomedicine & Pharmacotherapy. 2017 May 1;89:194-200.
Publication year: 2017
Induction of Apoptosis in MCF‐7 Breast Cancer Cells by Sri Lankan Endemic Mango (Mangifera zeylanica) Fruit Peel through Oxidative Stress and Analysis of its Phytochemical Constituents.
Research Articles
Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, De Silva ED. Induction of apoptosis in MCF‐7 breast cancer cells by Sri Lankan Endemic Mango (Mangifera zeylanica) fruit peel through oxidative stress and analysis of its phytochemical constituents. Journal of Food Biochemistry. 2017 Feb;41(1):e12294.
Publication year: 2017
In vitro anticancer effect of gedunin on human teratocarcinomal (NTERA-2) cancer stem-like cells
Research Articles
Tharmarajah L, Samarakoon SR, Ediriweera MK, Piyathilaka P, Tennekoon KH, Senathilake KS, Rajagopalan U, Galhena PB, Thabrew I. In vitro anticancer effect of gedunin on human teratocarcinomal (NTERA-2) cancer stem-like cells. BioMed research international. 2017 Jun 7;2017.
Publication year: 2017