- Development of subcellular optogenetic tools to interrogate GPCR-G protein mediated cellular signal transduction pathways involved in cellular behaviors at the single cell and subcellular resolution using live cell fluorescence-confocal and total internal reflection imaging.
- Structure-based protein engineering to generate light sensitive receptors (G protein coupled receptors).
Dr Kanishka Senarath
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Research
Research Interests
Research Skills
- Optogenetics
- Cell culturing and Live cell imaging
- Genetic engineering
- Molecular cloning
- Protein purification
- Gel electrophoresis (SDS-PAGE)
- Western Blotting
- Structure-based protein engineering
Research Training and Supervision
MSc Research Supervision
| Name of the
Student |
Year of
Completion |
MSc* | Title of the Thesis | Principal/Co-Supervisor |
| Ms. Naomi Navaneeta | In Progress | CMI 2020/2019 | Assessment of the effect of active components in Mikania cordata leaf extract on wound healing | Principle Supervisor |
Undergraduate Research Supervision
| Year | Name | Degree (Specialty) | Department/Faculty/University |
| 2020 | Ms Doniesha Perera | BSc (Molecular Biology and Biochemistry special) | Department of Chemistry, Faculty of Science, University of Colombo |
| 2020 | Ms. Gayesha Thilini | BSc (Molecular Biology and Biochemistry special) | Department of Chemistry, Faculty of Science, University of Colombo |