Current Teaching

Postgraduate

MSc Molecular Life Sciences – Cell Biology, Cellular communications, Cells in Social Context, Biological Membranes, Membrane Transport, Signal transduction, DNA replication, DNA repair, Cell Cycle, Cancer Biology and Cancer Genetics, Molecular Medicine

MSc Cellular and Molecular Immunology – Cell Biology, Cancer Biology and Cancer Genetics

MSc Bioinformatics  – Genetics, Genomics, Biochemistry and Cell Biology

MD Clinical Oncology – Cancer Biology / Cancer Genetics

Teaching History

Undergraduate medical students, BSc Pharmacy students, paramedical students (AMP, Physiotherapy, Radiology, Ophthalmic technicians, postbasic nurses)

MSc Biochemistry, Molecular Biology and Botechnology – Faculty of Medicine

Teaching Areas

Undergraduate

Physiology curriculum for Medical students

Postgraduate

MSc Molecular Life Sciences – Cell Biology, Cellular communications, Cells in Social Context, Biological Membranes, Membrane Transport, Signal transduction, DNA replication, DNA repair, Cell Cycle, Cancer Biology and Cancer Genetics, Molecular Medicine

MSc Cellular and Molecular Immunology – Cell Biology, Cancer Biology and Cancer Genetics

MSc Bioinformatics  – Genetics, Genomics, Biochemistry and Cell Biology

MD Clinical Oncology – Cancer Biology / Cancer Genetics

MPhil/PhD Supervision: 12 PhDs and 2 MPhils completed; 13 in progress

 

Name of the Student PhD/MPhil year of completion Title of the Thesis Principal / co-supervisor
S Jeevathayaparan PhD

1999

 

Oral hypoglycaemic activity of Momordica charantia: Possible mechanismssms of action and activity related fractionation Co-supervisor
S Wasalathanthri PhD

2001

 

Lactational amenorrhoea and some of its determinants in well-

nourished and undernourished women

Principal and sole supervisor
A N Pathmaperuma

 

MPhil

2006

 

A study on insulin-like growth factor –I, insulin-like growth factor binding protein-1 and major placental hormones during normal pregnancy Principal supervisor
T Eswaramohan PhD

2008

 

Expression of leptin and leptin receptors in the female reproductive tract and effect of leptin on endometrial cell function in the rat Principal supervisor
J W N De Silva

 

PhD

2009

Characterisation of sequence variants in the breast cancer susceptibility gene 1 (BRCA1) in selected Sri Lankan breast cancer patients and at risk individuals Co-supervisor
A Murugananthan MPhil

2010

Cloning and characterisation of Ackali myosin light chain gene (Mlc-3) of cattle filarial parasite Setaria digitata Co-supervisor

 

P Jayanthiny

 

PhD

2012

 

Insulin-like growth factor (IGF)-I, IGF-II and H 19 genotypes in a Sri Lankan birth cohort: Effect on maternal and cord blood levels of IGF-I and IGF binding protein-1, cord blood IGF-II and birth size Principal supervisor
Sumadee De Silva

 

PhD

2013

Characterisation of mutations and sequence variants in breast cancer susceptibility (BRCA) 2 gene in a selected group of breast cancer patients in Sri Lanka Principal supervisor
Y N Silva PhD

2012

 

Association between endometriosis and heavy metals in a group of Sri Lankan women of reproductive age Co-supervisor

 

SSR Samarakoon PhD

2014

Anti-hepatocarcinogenic effect of a traditional Sri Lankan herbal remedy: Modulation of expression of selected genes associated with carcinogenesis and identification of active compounds Co-supervisor
RACR Ranasinghe PhD

2016

Mitochondrial DNA analysis, haplotype and haplogroup determination and inference of maternal lineage in five major ethnic groups and Vedda population in Sri Lanka Principal supervisor
MACP Piyathilake PhD

2015

 

Molecular Identification of Toxigenic Cyanobacteria and Effects of Cyanotoxins on Human Renal Cell Lines Co-supervisor
AS Hewage PhD

2017

Selected polymorphisms of the H19 and IGF-II genes in a Sri Lankan birth cohort: Effect of maternal and newborn genotype on birth size Principal supervisor
EPM Keshawa PhD

2017

Possible anti-carcinogenic effects of Mangifera zeylanica: Identification of active compounds and evaluation of molecular mechanism Principal supervisor
HACIK Rodrigo PhD in progress Predictive biomarkers for sporadic breast cancer: Evaluation of circulating levels of leptin, soluble leptin receptor, insulin-like growth factor I, insulin-like growth factor binding protein-3 and visfatin and selected leptin and leptin receptor genotypes Principal supervisor
AS Mendis PhD in progress To evaluate potential use of flueggea leucopyrus & vernonia zeylanica in the treatment of breast cancer Co-supervisor
K Senathilake PhD Awaiting examination Search for antifilarial drugs from Sri Lankan medicinal plants Co-supervisor
T Sundralingam PhD in progress Characterization of mutations and sequence variants of growth hormone (GH) and growth hormone releasing hormone receptor (GHRH-R) in a cohort of Sri Lankan children with GH deficiency Principal supervisor
K Senanayake MPhil  in progress* Analysis of Setaria digitata Genome using NGS Technologies: Identification of potential drug targets in Setaria digitata Co-supervisor
V Manoharan PhD in progress Analysis of somatic mutation of TP53 in selected cancers among Sri Lankan patients Co-supervisor
U Rajagopalan PhD in progress Screening of Sri Lankan endemic plants for anti-cancer stem cell activity and evaluation of anti-cancer stem cell properties of isolated compounds from active plants for breast cancer Co-supervisor
MNS Wickramaratne MPhil in progress* Isolation structural and functional characterization of active antibreast cancer metabolites from endophytic fungi of plants and selected endemic / medicinal plants of Sri Lanka Co-supervisor
J Thushyanthan MPhil  in progress* Screening of selected endophytic fungi and endemic plants for anticancer activity using hepatocellular carcinoma (HepG2) cell line and isolation of active compounds Co-supervisor
BMLP Jayasekera MPhil  in progress* Mutations and polymorphisms of mitochondrial genes as risk factors for sporadic breast cancer in Sri Lankan patients of Sinhalese ethnicity Principal supervisor
JT Kotelawala MPhil  in progress* Characterisation of Mitochondrial DNA mutations in the D-loop and mtDNA haplogroups in Sporadic Breast Cancer.

 

Principal supervisor
RMRK Rathnayake

 

MPhil  in progress* Screening of compound libraries on a cancer cell panel and development of a synthetic anti-cancer compound libraryll line and isolation of active compounds Co-supervisor
A S Fernando MPhil  in progress* Insight for molecular anthropology of peopling in Sri Lanka: Ancient human mtDNA and molecular sex analysis of archaeological skeletal remains at Udupiyangalge and Alugalge caves Co-supervisor
AADN Perera MPhil  in progress* Evaluation of anti-cancer effects of Mangifera zeylanica plant extracts on non small lung cancer cell lines Principal supervisor
Nethu Wickramasinghe MPhil  in progress* Molecular systematics of the blindsnakes (Serpentes: Scolecophidia) of Sri Lanka

 

Co-supervisor
S Jeevathayaparan PhD

1999

 

Oral hypoglycaemic activity of Momordica charantia: Possible mechanismssms of action and activity related fractionation Co-supervisor
S Wasalathanthri PhD

2001

 

Lactational amenorrhoea and some of its determinants in well-

nourished and undernourished women

Principal and sole supervisor
A N Pathmaperuma

 

MPhil

2006

 

A study on insulin-like growth factor –I, insulin-like growth factor binding protein-1 and major placental hormones during normal pregnancy Principal supervisor
T Eswaramohan PhD

2008

 

Expression of leptin and leptin receptors in the female reproductive tract and effect of leptin on endometrial cell function in the rat Principal supervisor
J W N De Silva

 

PhD

2009

Characterisation of sequence variants in the breast cancer susceptibility gene 1 (BRCA1) in selected Sri Lankan breast cancer patients and at risk individuals Co-supervisor
A Murugananthan MPhil

2010

Cloning and characterisation of Ackali myosin light chain gene (Mlc-3) of cattle filarial parasite Setaria digitata Co-supervisor

 

P Jayanthiny

 

PhD

2012

 

Insulin-like growth factor (IGF)-I, IGF-II and H 19 genotypes in a Sri Lankan birth cohort: Effect on maternal and cord blood levels of IGF-I and IGF binding protein-1, cord blood IGF-II and birth size Principal supervisor
Sumadee De Silva

 

PhD

2013

Characterisation of mutations and sequence variants in breast cancer susceptibility (BRCA) 2 gene in a selected group of breast cancer patients in Sri Lanka Principal supervisor
Y N Silva PhD

2012

 

Association between endometriosis and heavy metals in a group of Sri Lankan women of reproductive age Co-supervisor

 

SSR Samarakoon PhD

2014

Anti-hepatocarcinogenic effect of a traditional Sri Lankan herbal remedy: Modulation of expression of selected genes associated with carcinogenesis and identification of active compounds Co-supervisor
RACR Ranasinghe PhD

2016

Mitochondrial DNA analysis, haplotype and haplogroup determination and inference of maternal lineage in five major ethnic groups and Vedda population in Sri Lanka Principal supervisor
MACP Piyathilake PhD

2015

 

Molecular Identification of Toxigenic Cyanobacteria and Effects of Cyanotoxins on Human Renal Cell Lines Co-supervisor
AS Hewage PhD

2017

Selected polymorphisms of the H19 and IGF-II genes in a Sri Lankan birth cohort: Effect of maternal and newborn genotype on birth size Principal supervisor
EPM Keshawa PhD

2017

Possible anti-carcinogenic effects of Mangifera zeylanica: Identification of active compounds and evaluation of molecular mechanism Principal supervisor
HACIK Rodrigo PhD in progress Predictive biomarkers for sporadic breast cancer: Evaluation of circulating levels of leptin, soluble leptin receptor, insulin-like growth factor I, insulin-like growth factor binding protein-3 and visfatin and selected leptin and leptin receptor genotypes Principal supervisor
AS Mendis PhD in progress To evaluate potential use of flueggea leucopyrus & vernonia zeylanica in the treatment of breast cancer Co-supervisor
K Senathilake PhD Awaiting examination Search for antifilarial drugs from Sri Lankan medicinal plants Co-supervisor
T Sundralingam PhD in progress Characterization of mutations and sequence variants of growth hormone (GH) and growth hormone releasing hormone receptor (GHRH-R) in a cohort of Sri Lankan children with GH deficiency Principal supervisor
K Senanayake MPhil  in progress* Analysis of Setaria digitata Genome using NGS Technologies: Identification of potential drug targets in Setaria digitata Co-supervisor
V Manoharan PhD in progress Analysis of somatic mutation of TP53 in selected cancers among Sri Lankan patients Co-supervisor
U Rajagopalan PhD in progress Screening of Sri Lankan endemic plants for anti-cancer stem cell activity and evaluation of anti-cancer stem cell properties of isolated compounds from active plants for breast cancer Co-supervisor
MNS Wickramaratne MPhil in progress* Isolation structural and functional characterization of active antibreast cancer metabolites from endophytic fungi of plants and selected endemic / medicinal plants of Sri Lanka Co-supervisor
J Thushyanthan MPhil  in progress* Screening of selected endophytic fungi and endemic plants for anticancer activity using hepatocellular carcinoma (HepG2) cell line and isolation of active compounds Co-supervisor
BMLP Jayasekera MPhil  in progress* Mutations and polymorphisms of mitochondrial genes as risk factors for sporadic breast cancer in Sri Lankan patients of Sinhalese ethnicity Principal supervisor
JT Kotelawala MPhil  in progress* Characterisation of Mitochondrial DNA mutations in the D-loop and mtDNA haplogroups in Sporadic Breast Cancer.

 

Principal supervisor
RMRK Rathnayake

 

MPhil  in progress* Screening of compound libraries on a cancer cell panel and development of a synthetic anti-cancer compound libraryll line and isolation of active compounds Co-supervisor
A S Fernando MPhil  in progress* Insight for molecular anthropology of peopling in Sri Lanka: Ancient human mtDNA and molecular sex analysis of archaeological skeletal remains at Udupiyangalge and Alugalge caves Co-supervisor
AADN Perera MPhil  in progress* Evaluation of anti-cancer effects of Mangifera zeylanica plant extracts on non small lung cancer cell lines Principal supervisor
Nethu Wickramasinghe MPhil  in progress* Molecular systematics of the blindsnakes (Serpentes: Scolecophidia) of Sri Lanka

 

Co-supervisor

 

Supervision of MSc Dissertations:

 

Name of the Student MSc / year of

completion

Title of the Thesis Principal / co-supervisor
P Jayanthiny

 

Biochemistry, Molecular Biology and Gene Technology

2006

Study of maternal and cord blood insulin-like growth factor (IGF) – I, -II and IGF binding protein–1 levels in normal pregnancies and in pregnancy induced hypertension / pre-eclampsia and gestational diabetes mellitus Principal supervisor

 

 

A D Gunaratne

 

Molecular Life Sciences – 2006 Screening of Sri Lankan breast cancer patients for germ line mutations in exon 8 of TP53 gene Principal supervisor

 

HVGS Wickramaratne

 

Molecular Life Sciences – 2007 Screening for germ-line mutations in exon 12 of BRCA 2 gene in as selected group of patients with family history of breast cancer and ovarian cancer Principal supervisor

 

H A C I K Rodrigo Molecular Life Sciences – 2007 Screening of a selected group of Sri Lankan breast cancer patients for germ line mutations in exon 7 of BRCA 2 gene Principal supervisor

 

RACR Ranasinghe Molecular Life Sciences -2007 Optimization of PCR conditions for the amplification of hypervariable region I and hypervariable region II  in the human mitochondrial D- loop. Principal supervisor

 

J.G. Rozani Molecular Life Sciences -2007 Screening for germ – line mutations of exon – 8 in the P53 gene in a family with a BRCA – 1 mutation Principal supervisor
WI Indika Molecular Life Sciences -2008 Gin 223Arg polymorphism in the leptin receptor: prevalence among Sri Lankan women with pre-eclampsia / pregnancy induced hypertension Principal supervisor
K. Vythilingam

 

Molecular Life Sciences -2008 Characterization of mutations and sequence variants in exon 11 of BRCA1 gene of sporadic breast cancer: A preliminary study on Sri Lankan patients Principal supervisor
Y.S. Wijayasinghe Applied Organic Chemistry-2008 Maternal plasma levels of placental growth factor in pregnancy induced hypertension/pre-eclampsia Principal supervisor
S D Gnanaratnam Cellular and Molecular Immunology-2008 Study of maternal insulin-like growth factor-I levels in normal pregnancies and in pregnancies complicated by pregnancy induced hypertension / pre-eclampsia Principal supervisor
S Sinnathamby

 

Molecular Life Sciences

2009

H19 polymorphism in newborns born to mothers with pregnancy induced hypertension/ preeclampsia Principal supervisor
T Siriwardena Molecular Life Sciences -2009 IGF-II APa-1 polymorphism in newborns, born to mothers with pregnancy induced hypertension / pre-eclampsia Principal supervisor
P Yasasni

 

Molecular Life Sciences -2010 The CA promoter polymorphism of IGF-I gene in pre-eclampsia / pregnancy induced hypertension Principal supervisor

 

SB Kotigala Molecular Life Sciences -2010 Effect of an herbal extract on the Caspase-3 and Caspase-9 expression in endometrial carcinoma cells Principal supervisor

 

B Sinthanaichselvan Molecular Life Sciences -2012 A preliminary analysis of mitochondrial haplogroups Principal supervisor

 

T Sundralingam Molecular Life Sciences -2014 Development of a multiplex SNP assay for selected CYP2D6 genotypes Principal supervisor

 

V Manoharan Molecular Life Sciences -2014 Optimization of DNA extraction from paraffin embedded tissues and preliminary analysis of somatic mutation of TP53 in breast cancer Principal supervisor

 

A Herath Molecular Life Sciences -2015 Y chromosome haplolyp analysis of Sri Lankans: A Preliminary study Principal supervisor

 

OKC De SIlva Molecular Life Sciences -2015 Possible potentiation of antiproliferative effect of tamoxifen in MCF-7 breast cancer cells by a bioactive extract of mangrove plant Scyphiphora hydrophyllacea: A pilot study Co-supervisor
S R Samarasinghe MSc Bioinformatics

2015

In silico analysis of missense mutations in human growth hormone: The impact on protein structure, dynamics and stability Principal supervisor

 

Karthika M MSc Bioinformatics

2015

Molecular docking study of selected natural compounds for cancer stem cells targeted anti-cancer activity Co- supervisor
SHDK Jayathilaka Molecular Life Sciences -2016 A pilot study on CYP21A2 gene deletion among Sri Lankan children with congenital adrenal hyperplasia

 

Principal supervisor

 

M VML Jayasundara Molecular Life Sciences -2016 A pilot study on selected point mutations of CYP21A2 gene among a cohort of Sri Lankan children with Congenital Adrenal Hyperplasia

 

Principal supervisor

 

I Wickramage Molecular Life Sciences -2016 Prevalence of selected polymorphisms of CYP2D6 gene in a cohort of breast cancer patients: Association with poor response to Tamoxifen Principal supervisor
AS Fernando Molecular Life Sciences -2018 Extensive analysis of human mitochondrial and Y-chromosome haplogroups among Sinhalese individuals with different Alu polymorphisms Co- supervisor
S Praveenan Molecular Life Sciences -2018 Analysis of common genetic mutations in a cohort of salt wasting form of congenital adrenal hyperplasia Co- supervisor
AADN Perera Molecular Life Sciences -2018 Development of in vitro transgenic model for anti-cancer drug discovery Co- supervisor