Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR.
Publication year: 2019

Ediriweera MK, Tennekoon KH, Samarakoon SR. (2019) Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. Semin Cancer Biol. 2019 May 22. pii: S1044-579X(18)30177-9. doi: 10.1016/j.semcancer.2019.05.012. [Epub ahead of print] Review. PubMed PMID:31128298.

Overview of the genetic basis toward early detection of breast cancer

Journal Paper
De Silva S, Tennekoon KH, Karunanayake EH
Publication year: 2019

De Silva S, Tennekoon KH, Karunanayake EH. (2019) Overview of the genetic basis toward early detection of breast cancer. Breast Cancer (Dove Med Press). 2019 21;11:71-80.

Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer

Journal Paper
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J.
Publication year: 2019

Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J. (2019) Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer. Mol Med Rep. 2019 Apr;19:2781-2791.

 

Isolation of a New SesquiterpeneLactone From VernoniaZeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines

Journal Paper
Mendis AS, Thabrew MI, Ediriweera MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED
Publication year: 2019

Mendis AS, Thabrew I, Ediriweera MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED. (2019) Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines. Anticancer Agents Med Chem. 2019;19:410-424.

In-vitro assays and techniques utilized in anti-cancer drug discovery

Journal Paper
Ediriweera MK, Samarakoon SR, Tennekoon KH
Publication year: 2019

Ediriweera MK, Samarakoon SR, Tennekoon KH (2019) In-vitro assays and techniques utilized in anti-cancer drug discovery. J Applied Toxicology Aug 2. doi: 10.1002/jat.3658

Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR.
Publication year: 2019

Ediriweera MK, Tennekoon KH, Samarakoon SR. (2019) Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents. Drug Discov Today. 2019 Mar;24:685-702

Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines

Journal Paper
Rajagopalan U, Samarakoon S R, Tennekoon KH, Malavige N, de Silva ED
Publication year: 2018

Rajagopalan U, Samarakoon S R, Tennekoon KH, Malavige N, de Silva ED (2018) Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines. Tropical Journal of Pharmaceutical Research 17 (9), 1825-1832

Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency

Journal Paper
Sundralingam T , Tennekoon KH , de Silva S, De Silva S, Hewage S , i Ranasinghe R
Publication year: 2018

Sundralingam T , Tennekoon KH , de Silva S, De Silva S, Hewage S , i Ranasinghe R (2018) Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency. Available on line 22 Oct 2018

Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae)

Journal Paper
Samarakoon SR, Ediriweera MK, Wijayabandara L, Fernand N, Tharmarajah L, Tennekoon KH, Piyathilaka P, Adhikari A
Publication year: 2018

Samarakoon SR, Ediriweera MK, Wijayabandara L, Fernand N, Tharmarajah L, Tennekoon KH, Piyathilaka P, Adhikari A (2018). Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae). Tropical Journal of Pharmaceutical Research  17: 475-481

Cytotoxic and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall. roots on human breast cancer (MCF-7) cells

Journal Paper
Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige GN, Thabrew MI, and Shrestha RL
Publication year: 2018

Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige GN, Thabrew MI, and Shrestha RL (2018 ) Cytotoxic and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall. roots on human breast cancer (MCF-7) cells. BioMed Research International Jul 24;2018:3171348. doi: 10.1155/2018/3171348. eCollection 2018

Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves

Journal Paper
Ediriweera MK, Jayarathna P, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, Adhikari A
Publication year: 2018

Ediriweera MK, Jayarathna P, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, Adhikari A (2018) Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves. Phytochemistry Letters 24: 114-119

Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells.

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED
Publication year: 2017

Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. (2017) Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells. Medicines (Basel). 2017 Jul 26;4(3). pii: E56. doi: 10.3390/medicines4030056

Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka

Journal Paper
Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS
Publication year: 2017

Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS. (2017) Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka. Growth Horm IGF Res. 36:22-29

Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro

Journal Paper
Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED, Adhikari A.
Publication year: 2017

Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED, Adhikari A. (2017) Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro. Exp Parasitol. 177:13-21

Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients.

Journal Paper
De Silva S, Tennekoon KH, Dissanayake A, De Silva K, Jayasekara L.
Publication year: 2017

De Silva S, Tennekoon KH, Dissanayake A, De Silva K, Jayasekara L. (2017) Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients. Fam Cancer. 16:329-338

Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR, Adhikari A, Thabrew I, Dilip de Silva E.
Publication year: 2017

Ediriweera MK, Tennekoon KH, Samarakoon SR, Adhikari A, Thabrew I, Dilip de Silva E. (2017) Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential. Biomed Pharmacother. 89:194-200. doi: 10.1016/j.biopha.2017.01.176. [Epub ahead of print]

In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells

Journal Paper
Tharmarajah L , Samarakoon SR, Ediriweera MK,  Piyathilaka P, Tennekoon KH, Senathilake KS, Rajagopalan U, Galhena PB, Thabrew I
Publication year: 2017

Tharmarajah L , Samarakoon SR, Ediriweera MK,  Piyathilaka P, Tennekoon KH, Senathilake KS, Rajagopalan U, Galhena PB, Thabrew I (2017)  In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells. Biomed Research International 2017;2017:2413197. doi: 10.1155/2017/2413197. Epub 2017 Jun 7

CYP2D6 polymorphisms may predict occurrence of adverse effects to tamoxifen: a preliminary retrospective study

Journal Paper
Wickramage I, Tennekoon KH, Ariyaratne MA, Hewage AS, Sundralingam T
Publication year: 2017

Wickramage I, Tennekoon KH, Ariyaratne MA, Hewage AS, Sundralingam T. (2017) CYP2D6 polymorphisms may predict occurrence of adverse effects to tamoxifen: a preliminary retrospective study. Breast Cancer (Dove Med Press). 9:111-120. doi: 10.2147/BCTT.S126557

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer.

Journal Paper
Rodrigo C, Tennekoon KH, Karunanayake EH, De Silva K, Amarasinghe I, Wijayasiri A.
Publication year: 2017

Rodrigo C, Tennekoon KH, Karunanayake EH, De Silva K, Amarasinghe I, Wijayasiri A. (2017) Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. Endocr J. 64:393-401

Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line

Journal Paper
Nwokwu DUC, Samarakoon SR, Karunaratne DN, Katuvawila NP, Ediriweera MK, Tennekoon KH
Publication year: 2017

Nwokwu DUC, Samarakoon SR, Karunaratne DN, Katuvawila NP, Ediriweera MK, Tennekoon KH (2017) Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line. Drug Delivery Letters 7: 219-226

Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea

Journal Paper
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED
Publication year: 2017

Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED (2017) Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S76-S83. doi: 10.4103/0973-1296.203989. Epub 2017 Apr 7

Anti-hepatocarcinogenic and anti-oxidant effects of mangrove plant Scyphiphora hydrophyllacea

Journal Paper
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED
Publication year: 2017

Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED (2017) Anti-hepatocarcinogenic and anti-oxidant effects of mangrove plant Scyphiphora hydrophyllacea. Pharmacognosy magazine 13: Suppl 1, S 7

A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O--L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells

Journal Paper
Samarakoon SR, Ediriweera MK, Nwokwu CDU, Bandara CJ, Tennekoon KH, Piyathilaka P, Karunaratne D, Karunaratne V
Publication year: 2017

Samarakoon SR, Ediriweera MK, Nwokwu CDU, Bandara CJ, Tennekoon KH, Piyathilaka P, Karunaratne D, Karunaratne V (2017).  A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O–L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells. BioMed Research International, Volume 2017 Article ID 9854083, https://doi.org/10.1155/2017/9854083

A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR
Publication year: 2017

Ediriweera MK, Tennekoon KH, Samarakoon SR. (2017) A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango). Evid Based Complement Alternat Med. 2017;2017:6949835. doi: 10.1155/2017/6949835. Epub 2017 Dec 31

A pilot study on CYP21 gene deletions among a cohort of Sri Lankan children with congenital adrenal hyperplasia

Journal Paper
Jayathilaka DK, Tennekoon KH, de Silva KSH, De Silva S
Publication year: 2017

Jayathilaka DK, Tennekoon KH, de Silva KSH, De Silva S. (2017) A pilot study on CYP21 gene deletions among a cohort of Sri Lankan children with congenital adrenal hyperplasia, Ceylon Medical Journal Jun 30;62:112-113

Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells

Journal Paper
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew
Publication year: 2016

Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew (2016) Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells. European Journal of Medicinal Plants, ISSN: 2231-0894,Vol.: 14, Issue.: 4 DOI : 9734/EJMP/2016/26107

Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro

Journal Paper
Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED
Publication year: 2016

Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED. (2016) Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro.Exp Parasitol. 2016 May 10;167:50-60. doi: 10.1016/j.exppara.2016.05.002. [Epub ahead of print

New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells. J Ethnopharmacol

Journal Paper
Ediriweera MK, Tennekoon KH, Adhikari A, Samarakoon SR, Thabrew I, de Silva ED
Publication year: 2016

Ediriweera MK, Tennekoon KH, Adhikari A, Samarakoon SR, Thabrew I, de Silva ED (2016) New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells. J Ethnopharmacol. 2016 May 17. pii: S0378-8741(16)30314-2. doi: 10.1016/j.jep.2016.05.047. [Epub ahead of print]

Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties

Journal Paper
Samarakoon SR, Fernando N, Ediriweera MK, Adhikari A, Wijayabandara L, de Silva ED,  Tennekoon KH
Publication year: 2016

Samarakoon SR, Fernando N, Ediriweera MK, Adhikari A, Wijayabandara L, de Silva ED,  Tennekoon KH (2016) Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties. British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 10, Issue.: 1 DOI : 10.9734/BJPR/2016/23317

Induction of Apoptosis in MCF-7 Breast Cancer Cells by Sri Lankan Endemic Mango (Mangifera zeylanica) Fruit Peel through Oxidative Stress and Analysis of its Phytochemical Constituents

Journal Paper
Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED
Publication year: 2016

Ediriweera PMK, Tennekoon KH, Samarakoon SRThabrew I, de Silva ED. (2016) Induction of Apoptosis in MCF-7 Breast Cancer Cells by Sri Lankan Endemic Mango (Mangifera zeylanica) Fruit Peel through Oxidative Stress and Analysis of its Phytochemical Constituents. J Food Biochemistry 28 MAY 2016 DOI: 10.1111/jfbc.12294