Dr Kanishka Senarath
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
Tennakoon M, Senarath K, Kankanamge D, Ratnayake K, Wijayaratna D, Olupothage K,
Ubeysinghe S, Martins-Cannavino K, Hébert TE, Karunarathne A (2021) Subtypedependent regulation of Gβγ signalling. Cellular Signaling 82:109947.
A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy
Tennakoon M, Senarath K, Kankanamge D, Chadee DN, & Karunarathne A (2021) A short C-terminal peptide in Gγ regulates Gβγ signaling efficacy. Molecular Biology of the Cell:mbcE20110750. PMID: 34106735
Microcystins: biogenesis, toxicity, analysis and control
Schreidah C.M, Ratnayake K, Senarath K, and Karunarathne A (2020), Microcystins:
biogenesis, toxicity, analysis and control. Chemical Research in Toxicology 33(9):2225-
2246.
Statins perturb Gβγ signaling and cell behaviors in a Gγ subtype dependent manner
Tennakoon M, Kankanamge D, Senarath K, Fasih Z, & Karunarathne A (2019) Statins
perturb Gβγ signaling and cell behaviors in a Gγ subtype dependent manner. Molecular
Pharmacology 95(4):361-375.
Optical approaches for single-cell and subcellular analysis of GPCR–G protein signaling
Kankanamge D, Ratnayake K, Senarath K, Tennakoon M, Harmon E, & Karunarathne A
(2019) Optical approaches for single-cell and subcellular analysis of GPCR–G protein
signaling. Analytical and Bioanalytical Chemistry 411(19):4481-4508.
Short preCaaX regions in Gγ are uniquely evolved switches of heterotrimeric G protein signaling
Kanishka Senarath, Mithila Tennakoon, Deborah N. Chadee, and Ajith Karunarathne,
GPCR Retreat 2018, Annual meeting, Detroit, Michigan, USA, Poster title: “Short preCaaX regions in Gγ are uniquely evolved switches of heterotrimeric G protein
signaling”, October 25-27, 2018
Opsins in action-light directed subcellular signaling and cell behaviors
Ratnayake K, Kanishka Senarath, Siripurapu P, Kankanamge D, Karunarathne A,
American Society for Photobiology ASP 2018 Biennial Meeting, Tampa-FL, USA, Talk
title: Opsins in action-light directed subcellular signaling and cell behaviors, May 12-15,
2018.
Gγ identity dictates efficacy of Gβγ signaling and macrophage migration
Senarath K, Payton JL, Kankanamge D, Siripurapu P, Tennakoon M, & Karunarathne A
(2018) Gγ identity dictates efficacy of Gβγ signaling and macrophage migration. Journal
of Biological Chemistry 293(8):2974-2989.
GRC Meeting on Protein Phosphorylation and G-Protein Mediated Signaling Networks
Kanishka Senarath, John L. Payton, Dinesh Kankanamge, Praneeth Siripurapu, Mithila
Tennakoon, Ajith Karunarathne, GRC Meeting on Protein Phosphorylation and G-Protein
Mediated Signaling Networks, University of New England, NE, USA, Talk title: Identity
matters: Ggamma-type dictates efficacy of Gbetagamma signaling and cellular decisions,
June 3 – 8, 2018.
G protein γ (Gγ) subtype dependent targeting of GRK2 to M3 receptor by Gβγ
Samaradivakara S, Kankanamge D, Senarath K, Ratnayake K, & Karunarathne A (2018)
G protein γ (Gγ) subtype dependent targeting of GRK2 to M3 receptor by Gβγ.
Biochemical and biophysical research communications 503(1):165-170
Cone opsin based chimeric receptors are equally efficient as ligand binding GPCRs
Kanishka Senarath and Ajith Karunarathne, 18th International Conference on Retinal
Proteins (ICRP) 2018, Ontario, Canada, Poster title: “Cone opsin based chimeric receptors
are equally efficient as ligand binding GPCRs”, September 24-29, 2018.
Chapter Five - Regulation of G Protein βγ Signaling
Senarath K, Kankanamge D, Samaradivakara S, Ratnayake K, Tennakoon M, &
Karunarathne A (2018) Chapter Five – Regulation of G Protein βγ Signaling. International
Review of Cell and Molecular Biology, ed Shukla AK (Academic Press), Vol 339, pp 133-
191.
Two independent but synchronized Gβγ subunit−controlled pathways are essential for trailingedge retraction during macrophage migration
Siripurapu P, Kankanamge D, Ratnayake K, Senarath K, & Karunarathne A (2017) Two
independent but synchronized Gβγ subunit−controlled pathways are essential for trailingedge retraction during macrophage migration. Journal of Biological Chemistry
292(42):17482-17495.
Subcellular optogenetics: the search light for hidden treasures
A. Karunarathne, D. Kankanamge, P. Siripurapu, K. Ratnayake, Kanishka Senarath,
2017-ACS- Central Regional Meeting (CERM), Dearborn, MI, USA, Talk title:
Subcellular optogenetics: the search light for hidden treasures, June 7, 2017
Reversible Distribution of G Protein βγ9 Based Assay for Real-Time Quantification of GPCR and G Protein Function in Living Cells
Kanishka Senarath, Kasun Ratnayake, Praneeth Siripurapu, John L. Payton, Ajith
Karunarathne, PITTCON 2017, Chicago, Illinois, USA, Talk title: “Reversible Distribution
of G Protein βγ9 Based Assay for Real-Time Quantification of GPCR and G Protein
Function in Living Cells”, March 5-9, 2017.
Chapter 1 - Measurement of GPCR-G protein activity in living cells
Ratnayake K, Kankanamge D, Senarath K, Siripurapu P, Weis N, Tennakoon M, Payton
JL, & Karunarathne A (2017) Chapter 1 – Measurement of GPCR-G protein activity in
living cells. Methods in Cell Biology, ed Shukla AK (Academic Press), Vol 142, pp 1-25.
Reversible G Protein βγ9 Distribution-Based Assay Reveals Molecular Underpinnings in Subcellular, Single-Cell, and Multicellular GPCR and G Protein Activity
Senarath K, Ratnayake K, Siripurapu P, Payton JL, & Karunarathne A (2016) Reversible
G Protein βγ9 Distribution-Based Assay Reveals Molecular Underpinnings in Subcellular,
Single-Cell, and Multicellular GPCR and G Protein Activity. Analytical Chemistry
88(23):11450-11459.
Non Specific Amplification with the LAMP Technique in the Diagnosis of Tuberculosis in Sri Lankan Settings
Senarath KD, Usgodaarachchi, R., Navaratne, V., Nagahawatte, A., Wijayarathna, C.,
Alvitigala, J. and Goonasekara, C. (2014) Non Specific Amplification with the LAMP
Technique in the Diagnosis of Tuberculosis in Sri Lankan Settings. Journal of Tuberculosis
Research 2(4):168-172.
A noval molecular assay for diagnosis of Tuberculosis: Problems in establishment
K. D. Senarath, V. Navaratne, C. D. Wijayarathna, A. Nagahawatte, J. Elvitigala, C. L.
Goonasekara, International Research Sessions (iPURSE), University of Peradeniya, Sri
Lanka, Talk title: “A noval molecular assay for diagnosis of Tuberculosis: Problems in
establishment”, July 2014.