A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

1. International peer reviewed articles
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, and Sameera Ranganath Samarakoon
Publication year: 2017

Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, and Sameera Ranganath Samarakoon. A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango). Evidence-Based Complementary and Alternative Medicine. Volume 2017 (2017), Article ID 6949835, 24 page

Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells

1. International peer reviewed articles
Sameera R Samarakoon*, Chanthirika Shanmuganathan, Meran K Ediriweera, Poorna Piyathilaka, Kamani H Tennekoon, Ira Thabrew
Publication year: 2016

Sameera R Samarakoon*, Chanthirika Shanmuganathan, Meran K Ediriweera, Poorna Piyathilaka, Kamani H Tennekoon, Ira Thabrew.  Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells. European journal of medicinal plants. 2016.14.4.1-11.

Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro

1. International peer reviewed articles
Senathilake KS,  Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED
Publication year: 2016

Senathilake KS,  Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED. Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro. Experimental Parasitology2016.167;50-60. – doi:10.1016/j.exppara.2016.05.002

Preparation, characterization and in vitro anti proliferative studies of doxorubicin loaded chitosan and chitosan-alginate nanoparticles on MCF-7 cell line

1. International peer reviewed articles
K.A.N.P. Katuwavila, A.D.L.C.Perera, S.R. Samarakoon, S.S.S.B.D.P. Soysa, V.Karunaratne, G.A.J. Amaratunga, and D.N.Karunaratne
Publication year: 2016

K.A.N.P. Katuwavila, A.D.L.C.Perera, S.R. Samarakoon, S.S.S.B.D.P. Soysa, V.Karunaratne, G.A.J. Amaratunga, and D.N.Karunaratne. Preparation, characterization and in vitro anti proliferative studies of doxorubicin loaded chitosan and chitosan-alginate nanoparticles on MCF-7 cell line.-  journal of Nanomaterials– 2016.Article ID 3178904.

Potential in vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant Phoenix paludosa Roxb

1. International peer reviewed articles
Samarakoon SR*, Chanthirika S. Tennekoon KH, Thabrew MI, Ediriweera PMK, Piyathilaka MAPC, de Silva ED
Publication year: 2016

Samarakoon SR*, Chanthirika S. Tennekoon KH, Thabrew MI, Ediriweera PMK, Piyathilaka MAPC, de Silva ED.  Potential in vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant Phoenix paludosa Roxb. Tropical Journal of Pharmaceutical Research – 2016; 15 (1): 127-132.

New halogenated compounds from Mangifera zeylanica, Sri Lankan endemic mango and their potential anticancer effects in breast and ovarian cancer cells

1. International peer reviewed articles
Ediriweera PMK, Tennekoon KH, Adhikari A, Samarakoon SR, Thabrew I, de Silva ED
Publication year: 2016

Ediriweera PMK, Tennekoon KH, Adhikari A, Samarakoon SRThabrew I, de Silva ED,. New halogenated compounds from Mangifera zeylanica, Sri Lankan endemic mango and their potential anticancer effects in breast and ovarian cancer cells –Journal  of Ethnopharmacolgoy- 189 (2016) 165–174. (doi:10.1016/j.jep.2016.05.047).

Molecular docking study of selected natural compounds for cancer stem cells targeted anti-cancer activity

1. International peer reviewed articles
Karthika Mayan, Sameera Ranganath Samarakoon*, Kamani Hemamala Tennekoon, Asitha Siriwardana, José R Valverde
Publication year: 2016

Karthika Mayan, Sameera Ranganath Samarakoon*, Kamani Hemamala Tennekoon, Asitha Siriwardana, José R Valverde. Molecular docking study of selected natural compounds for cancer stem cells targeted anti-cancer activity. European journal of medicinal plants. 2016. 15(4): 1-21

Cytotoxic, Antioxidant and Apoptotic Effects of Twenty Sri Lankan Endemic Plants in Breast Cancer Cells

1. International peer reviewed articles
Panchima P. Jayarathna , Kamani H. Tennekoon, Sameera R. Samarakoon , Ira Thabrew , Eric H. Karunanayake, E. Dilip de Silva and Meran K. Ediriweera
Publication year: 2016

Panchima P. Jayarathna , Kamani H. Tennekoon, Sameera R. Samarakoon , Ira Thabrew , Eric H. Karunanayake, E. Dilip de Silva and Meran K. Ediriweera.  Cytotoxic, Antioxidant and Apoptotic Effects of Twenty Sri Lankan Endemic Plants in Breast Cancer Cells. European Journal of Medicinal Plants. 2016. 15(1): 1-15

Cytotoxic and apoptotic effects of the bark of two common mango (Mangifera indica) varieties from Sri Lanka on breast and ovarian cancer cells

1. International peer reviewed articles
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon, Ira Thabrew, Dilip de Silva
Publication year: 2016

Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon, Ira Thabrew, Dilip de Silva. Cytotoxic and apoptotic effects of the bark of two common mango (Mangifera indica) varieties from Sri Lanka on breast and ovarian cancer cells- British Journal of Pharmaceutical Research – 2016: 10(2): 1-7.

A study on potential anti-cancer activity of Mangifera zeylanica bark:  Evaluation of cytotoxic and apoptotic effects of the hexane extract and bioassay guided fractionation to identify phytochemical constituents

1. International peer reviewed articles
Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED
Publication year: 2016

Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. A study on potential anti-cancer activity of Mangifera zeylanica bark:  Evaluation of cytotoxic and apoptotic effects of the hexane extract and bioassay guided fractionation to identify phytochemical constituents. Oncology letters- 2016: 11: 1335-1344.

Pseudophilautus dilmah, a new species of shrub frog (Amphibia: Anura: Rhacophoridae) from a threatened habitat Loolkandura in Sri Lanka

1. International peer reviewed articles
Wickramasinghe, L.J.M., I.N. Bandara, D.R. Vidanapathirana, K.H. Tennakoon, S.R. Samarakoon & N. Wickramasinghe
Publication year: 2015

Wickramasinghe, L.J.M., I.N. Bandara, D.R. Vidanapathirana, K.H. Tennakoon, S.R. Samarakoon & N. Wickramasinghe .Pseudophilautus dilmah, a new species of shrub frog (Amphibia: Anura: Rhacophoridae) from a threatened habitat Loolkandura in Sri Lanka. Journal of Threatened Taxa. 2015:7(5): 7089-110.

Modulation of Heat Shock Proteins and Apoptosis by Flueggea leucopyrus (Willd) decoction: possible mechanisms mediating cytotoxicity to three breast cancer phenotypes

1. International peer reviewed articles
Anuka S. Mendis, Ira Thabrew, Sameera R. Samarakoon and Kamani H. Tennekoon
Publication year: 2015

Anuka S. Mendis, Ira Thabrew, Sameera R. Samarakoon and Kamani H. Tennekoon. Modulation of Heat Shock Proteins and Apoptosis by Flueggea leucopyrus (Willd) decoction: possible mechanisms mediating cytotoxicity to three breast cancer phenotypes. BMC Complementary and alternative Medicine: 2015:15:404.

Microcystin LR induced cytotoxicity and apoptosis on human embryonic kidney (HEK 293) and human kidney adenocarcinoma (ACHN) cell lines

1. International peer reviewed articles
Piyathilaka M.A.P.C., Pathmalal M.M., Tennekoon K.H., Samarakoon S.R., Chanthirika S., and B.G.D.N.K. de Silva
Publication year: 2015

Piyathilaka M.A.P.C., Pathmalal M.M., Tennekoon K.H., Samarakoon S.R., Chanthirika S., and B.G.D.N.K. de Silva. Microcystin LR induced cytotoxicity and apoptosis on human embryonic kidney (HEK 293) and human kidney adenocarcinoma (ACHN) cell lines. Microbiology– 29th January 2015.

Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties

1. International peer reviewed articles
Sameera Ranganath Samarakoon*, Nisala Fernando, Meran Keshawa Ediriweera, Achyut Adhikari, Lakshan Wijayabandara, E. Dilip de Silva and Kamani Hemamala Tennekoon
Publication year: 2015

Sameera Ranganath Samarakoon*, Nisala Fernando, Meran Keshawa Ediriweera, Achyut Adhikari, Lakshan Wijayabandara, E. Dilip de Silva and Kamani Hemamala Tennekoon. Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties. British Journal of Pharmaceutical Research. published online 29th December 2015: 10(1): 1-6.

n silico characterization of a RNA binding protein of cattle filarial parasite Setaria digitata

1. International peer reviewed articles
Nirupa Nagaratnam, Eric H Karunanayake, Kamani H Tennekoon, Sameera R Samarakoon, Karthika Mayan
Publication year: 2014

Nirupa Nagaratnam, Eric H Karunanayake, Kamani H Tennekoon, Sameera R Samarakoon, Karthika Mayan. In silico characterization of a RNA binding protein of cattle filarial parasite Setaria digitata. Bioinformation- 2014.10(8): 521-516.

Anti-carcinogenic effects of a standardized Flueggea leucopyrus (aerial parts) decoction on human endometrial carcinoma (AN3CA) cells

1. International peer reviewed articles
Sameera R Samarakoon*, Saman B Kotigala, Ishani Gammana-Liyanage, , Ira Thabrew, Kamani H Tennekoon
Publication year: 2014

Sameera R Samarakoon*, Saman B Kotigala, Ishani Gammana-Liyanage, , Ira Thabrew, Kamani H Tennekoon Anti-carcinogenic effects of a standardized Flueggea leucopyrus (aerial parts) decoction on human endometrial carcinoma (AN3CA) cells. Tropical Journal of Pharmaceutical Research– 2014; 13 (6): 873-880.

Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis

1. International peer reviewed articles
Nalinda Silva, Kamani Tennekoon, Hemantha Senanayake, Sameera Samarakoon
Publication year: 2013

Nalinda Silva, Kamani Tennekoon, Hemantha Senanayake, Sameera Samarakoon. Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis. Taiwan Association of Obstetrics and Gynecology. 2013, 52: 540-545.

Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction with anti- hepatocarcinogenic effects

1. International peer reviewed articles
Sameera Samarakoon*, Ira Thabrew, Kamani Tennekoon
Publication year: 2012

Sameera Samarakoon*, Ira Thabrew, Kamani Tennekoon, Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction with anti- hepatocarcinogenic effects. BMC complementary and alternative medicine 2012, 12:25

Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis

1. International peer reviewed articles
Sameera R. Samarakoon*, Ira Thabrew, Prasanna B. Galhena, Kamani H. Tennekoon
Publication year: 2012

Sameera R. Samarakoon*, Ira Thabrew, Prasanna B. Galhena, Kamani H. Tennekoon. Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis. Tropical Journal of Pharmacutical research. 2012; 11 (1): 51-61.

Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (root), and Smilax glabra (rhizome) mediates its anti-hepatocarcinogenic effects. Evidence-Based Complementary and Alternative Medicine

1. International peer reviewed articles
Prasanna B Galhena, Sameera R Samarakoon, Ira M Thabrew, Mayuri G Thammitiyagodage, W. D Rathnasooriya, Kamani H Tennekoon
Publication year: 2012

Prasanna B Galhena, Sameera R Samarakoon, Ira M Thabrew, Mayuri G Thammitiyagodage, W. D Rathnasooriya, Kamani H Tennekoon. Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (root), and Smilax glabra (rhizome) mediates its anti-hepatocarcinogenic effects. Evidence-Based Complementary and Alternative Medicine. 2012; doi:10.1155/2012/108626.

A Comparison of Cytotoxic Potentials of Standardized Aqueous and Ethanolic Extracts of a Polyherbal Mixture Comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome)

1. International peer reviewed articles
Samarakoon Sameera R*, Thabrew Ira,  Galhena B Prasanna, De Silva Dilip, Tennekoon Kamani H
Publication year: 2010

Samarakoon Sameera R*, Thabrew Ira,  Galhena B Prasanna, De Silva Dilip, Tennekoon Kamani H, A Comparison of Cytotoxic Potentials of Standardized Aqueous and Ethanolic Extracts of a Polyherbal Mixture Comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome).- Pharmacognosy Research. 2 (6), (2010), 335 – 342