Prof. Sameera R Samarakoon
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
Development of a New Nanocarrier for Dietary Garcinol: Characterization and In Vitro Efficacy Evaluation Using Breast Cancer Stem Cells Grown in Hypoxia
Amal Charindra Hulangamuwa, Meran Keshawa Ediriweera, Umapriyatharshini Rajagopalan, Desiree Nedra Karunaratne, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon. Development of a New Nanocarrier for Dietary Garcinol: Characterization and In Vitro Efficacy Evaluation Using Breast Cancer Stem Cells Grown in Hypoxia. Journal of Food Quality. 2021. https://doi.org/10.1155/2021/6654211
Virtual screening of inhibitors against spike glycoprotein of 2019 novel corona virus: A drug repurposing approach
Kanishka Senathilake, Sameera Samarakoon, Kamani Tennekoon. Virtual screening of inhibitors against spike glycoprotein of 2019 novel corona virus: A drug repurposing approach. Preprints. 2020. 10.20944/preprints202003.0042.v2
The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites
Kanchana S Senanayake, Jonas Söderberg, Aleksei Põlajev, Maja Malmberg, Eric H Karunanayake, Kamani H Tennekoon, Sameera R Samarakoon, Erik Bongcam-Rudloff, Adnan Niazi. The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites. Genome Biology and Evolution.2020. 12.2. 3971-3976. https://doi.org/10.1093/gbe/evaa017
Synthesis and characterization of novel naphthalene-derivatized tridentate ligands and their net neutral rhenium tricarbonyl complexes and cytotoxic effects on non-small cell lung cancer cells of interest
Taniya Darshani, Frank R Fronczek, Varuni V Priyadarshani, Sameera R Samarakoon, Inoka C Perera, Theshini Perera. Synthesis and characterization of novel naphthalene-derivatized tridentate ligands and their net neutral rhenium tricarbonyl complexes and cytotoxic effects on non-small cell lung cancer cells of interest. Polyhedron. 2020. 114652. https://doi.org/10.1016/j.poly.2020.114652.
Novel Cytotoxic Compound From the Endolichenic Fungus, Xylaria psidii Inhabiting the Lichen, Amandinea medusulina
Sinthujah Santhirasegaram, Suranga R Wickramarachchi, Renuka N Attanayake, Gothamie Weerakoon, Sameera Samarakoon, Kithsiri Wijeratne, Priyani A Paranagama. A Novel Cytotoxic Compound From the Endolichenic Fungus, Xylaria psidii Inhabiting the Lichen, Amandinea medusulina. Natural Product Communications. 2020. 15.7. https://doi.org/10.1177/1934578X20933017
Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line
Varuni Colamba Pathiranage, Jesiska Nirmalee Lowe, Umapriyatharshini Rajagopalan, Meran Keshawa Ediriweera, Kanishka Senathilake, Poorna Piyathilaka, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon. Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line MDA-MB-231. Nutrition and Cancer. 2020. 1-11. https://doi.org/10.1080/01635581.2020.1773511
Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells
Varuni Colamba Pathiranage, Ira Thabrew, Sameera R Samarakoon, Kamani H Tennekoon, Umapriyatharshini Rajagopalan, Meran K Ediriweera. Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells. Journal of Integrative Medicine. 2020. https://doi.org/10.1016/j.joim.2020.02.007
An efficient and high-yielding method for extraction and purification of linamarin from Cassava; in vitro biological evaluation
KAU Samanthi, Dhanushi T Welideniya, Anjana Delpe Acharige, Sameera R Samarakoon, Rajitha K Rathnayaka, Madhavi de Silva, Shashika S Perera, Colin Pieris, Umayangani K Wanninayake, Adeesha Jayathilaka, Veranja Karunaratne, GAJ Amaratunga, Dinara S Gunasekera. An efficient and high-yielding method for extraction and purification of linamarin from Cassava; in vitro biological evaluation. Natural Product Research. 2020.1-4. https://doi.org/10.1080/14786419.2020.1744136
Vernolactone promotes apoptosis and autophagy in human teratocarcinomal (NTERA-2) cancer stem-like cells
Nuwanka K Abeysinghe, Ira Thabrew, Sameera R Samarakoon, Meran K Ediriweera, Kamani H Tennekoon, Varuni PC Pathiranage, Anuka S Mendis. Vernolactone promotes apoptosis and autophagy in human teratocarcinomal (NTERA-2) cancer stem-like cells. Stem Cells International. 2019. https://doi.org/10.1155/2019/6907893.
Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon. Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. Seminars in cancer biology. 2019. https://doi.org/10.1016/j.semcancer.2019.05.012
In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon. In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery. Frontiers in Anti-Cancer Drug Discovery Volume 10. 2019. page 10-43. Bentham Science Publishers.
In vitro effects of cadmium on cultured human endometrial stromal cells
N Silva, K Tennekoon, H Senanayake, S Samarakoon, S Fernando, R Wickramasinghe. In vitro effects of cadmium on cultured human endometrial stromal cells. 3rd Biennial conference of the South Asian Association of Physiologist (SAAP3) 7th-10th November, Sri Lanka.
Evaluation of the effects of proanthocyanidins extracted from the bark of Thespesia populnea (L.) Sol.ex Correa, on cell survival and apoptosis of human hepatoma (HepG2) cells
Tharmarajah L, Thabrew I, Samarakoon SR, Mendis AS, Padumadasa C. Evaluation of the effects of proanthocyanidins extracted from the bark of Thespesia populnea (L.) Sol.ex Correa, on cell survival and apoptosis of human hepatoma (HepG2) cells. 8th Annual Scientific Sessions 27st May, 2016. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon. Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents. Drug Discovery Today. 2019. https://doi.org/10.1016/j.drudis.2019.02.003.
Effect of natural curcuminoids‐intercalated layered double hydroxide nanohybrid against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis
Buddhika Gayani, Ayomi Dilhari, Gayan Kanchana Wijesinghe, Sajeewani Kumarage, Gayani Abayaweera, Sameera R Samarakoon, Inoka C Perera, Nilwala Kottegoda, Manjula M Weerasekera. Effect of natural curcuminoids‐intercalated layered double hydroxide nanohybrid against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis: A bactericidal, antibiofilm, and mechanistic study. MicrobiologyOpen. 2019. https://doi.org/10.1002/mbo3.723.
Study on cytotoxic and apoptotic potential of Barringtonia asiatica seed kernel against HepG2 cell line
Ragutharan P, Ekanayake S and Samarakoon SR. Study on cytotoxic and apoptotic potential of Barringtonia asiatica seed kernel against HepG2 cell line, Asian Symposium on Medicinal Palnts, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018, pp: 96.
Some endolichenic fungi (ELF) from mangrove ecosystem in Puttalam lagoon, Sri Lanka show anticancer activity
Maduranga HAK, Sinhthujah S, Samarakoon SR, Wichramarachchi S, Weerakoon G and Paranagam PA. Some endolichenic fungi (ELF) from mangrove ecosystem in Puttalam lagoon, Sri Lanka show anticancer activity. Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018.
Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines
Umapriyatharshini Rajagopalan, Sameera R Samarakoon, Kamani H Tennekoon, Neelika Malavige, ED de Silva. Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines. Tropical Journal of Pharmaceutical Research. 2018. 17, 9, 1825-1832.
Screening cytotoxic activity of selected endolichenic fungal strains isolated from lichens collected from Puttalam lagoon in Sri Lanka
Sinhthujah S, Maduranga HAK, Samarakoon SR, Wichramarachchi S, Weerakoon G and Paranagama PA. Screening cytotoxic activity of selected endolichenic fungal strains isolated from lichens collected from Puttalam lagoon in Sri Lanka. Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI 2018, Colombo, Sri Lanka, 12-14th December 2018
Phytochemical analysis and cytotoxicity of medicinal plant Gardenia crameri; an endemic plant of Sri Lanka
Wickramaratne N, Thusyanthan J, Fernando A, Samarakoon SR, Karunaratne N and Tennekoon KH. Phytochemical analysis and cytotoxicity of medicinal plant Gardenia crameri; an endemic plant of Sri Lanka. Asian Symposium on Medicinal Palnts, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018, pp: 219.
Molecular and Biochemical Investigation of Microcystin in Paddy Water and Two Water Resources in Makandura, Sri Lanka
Kuruvita, K.G.O.S., Piyathilaka, M.A.P.C. andSamarakoon, S.R.2018. Molecular and Biochemical Investigation of Microcystin in Paddy Water and Two Water Resources in Makandura, Sri Lanka. Proceedings of 17th Agricultural Research Symposium, Part I.
Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea C.F.Gaertn (Rubiaceae)
Sameera R Samarakoon*, Meran K Ediriweera, Lakshan Wijayabandara, Nisala Fernando, Luxmiga Tharmarajah, Kamani H Tennekoon, Poorna Piyathilaka, Achyut Adhikari. Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea C.F.Gaertn (Rubiaceae). Tropical Journal of Pharmaceutical Research March 2018; 17 (3): 475-481.
Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines
Mendis AS, Thabrew MI, Ediriweer MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED. Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines. Anti-Cancer Agents in Medicinal Chemistry. 2018. Nov 28. doi: 10.2174/1871520619666181128163359.
In-vitro screening of a small compound library against a panel of human cancer cell lines
Rathnayaka RMRK, Samarakoon SR, Tennekoon KH and Ediriweera MK. In-vitro screening of a small compound library against a panel of human cancer cell lines. Asian Symposium on Medicinal Palnts, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018, pp: 246.
In vitro assays and techniques utilized in anticancer drug discovery. Journal of Applied Toxicology
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon. In vitro assays and techniques utilized in anticancer drug discovery. Journal of Applied Toxicology. 2018 Aug 2. doi: 10.1002/jat.3658.
In vitro assays and techniques utilized in anticancer drug discovery
Ediriweera MK, Tennekoon KH, Samarakoon SR. In vitro assays and techniques utilized in anticancer drug discovery. J Appl Toxicol. 2018;1–34. https://doi. org/10.1002/jat.3658.
In vitro anti-cancer effects of compound A isolated from Vernonia zeylanica on embryonal carcinoma cells (NTERA-2 cl. D1)
Abeysinghe NK, Thabrew MI, Samarakoon SR, Tennakoon KH, Ediriweera MK, Priyadarshani CPVV and Mendis A. In vitro anti-cancer effects of compound A isolated from Vernonia zeylanica on embryonal carcinoma cells (NTERA-2 cl. D1). Asian Symposium on Medicinal Palnts, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018, pp: 132.
Evaluating the anticancer mechanisms mediated by an organic solvent-based extract of a polyherbal mixture in lung cancer (NCI-H292) cells
Priyadarshan CPVV, Thabrew I, Samarakoon SR, Rajagopalan U and Ediriweera MK. Evaluating the anticancer mechanisms mediated by an organic solvent-based extract of a polyherbal mixture in lung cancer (NCI-H292) cells. Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018.
Effect of natural curcuminoids-intercalated layered double hydroxide nanohybrid against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis
Nilwala Kottegoda Gayan Kanchana Wijesinghe, Sajeewani Kumarage, Gayani Abayaweera, Sameera R. Samarakoon, Inoka C. Perera, Manjula M. Weerasekera Buddhika Gayani, Ayomi Dilhari. Effect of natural curcuminoids-intercalated layered double hydroxide nanohybrid against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis: A bactericidal, antibiofilm, and mechanistic study. Microbiologyopen. 2018 Sep 17:e00723.
Development of an in-vitro transgenic model for anti-cancer drug discovery by using CRISPR/Cas 9 genome editing tool
Perera AADN, Senathilake KS, Samarakoon SR, Tennekoon KH. Development of an in-vitro transgenic model for anti-cancer drug discovery by using CRISPR/Cas 9 genome editing tool. Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018, pp: 147.