Overview of the genetic basis towards early detection of breast cancer. Breast Cancer

Publication
De Silva S, Tennekoon KH , Karunanayake EH
Publication year: 2019

De Silva S, Tennekoon KH , Karunanayake EH. Overview of the genetic basis towards early detection of breast cancer. Breast Cancer: Targets and Therapy, 2019 (in press)

Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of head and neck cancer patients

Publication
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J
Publication year: 2019

Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J. Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of head and neck cancer patients. Molecular Medicine Reports, 2019 (accepted for publication)

Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency

Publication
Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS, Ranasinghe R
Publication year: 2018

Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS, Ranasinghe R. Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency. Growth Hormone & IGF Research, 2018; 42–43:94-101. Doi: https://doi.org/10.1016/j.ghir.2018.10.005

Charaterization and identification of the mechanism behind formation of a novel gross deletion at GHRHR gene locus leading to isolated growth hormone deficiency

Local Communications
Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS, Ranasinghe R
Publication year: 2018

Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS, Ranasinghe R. Charaterization and identification of the mechanism behind formation of a novel gross deletion at GHRHR gene locus leading to isolated growth hormone deficiency. Proceedings of the 10th Annual Scientific Sessions, Institute of Biochemistry, Molecular Biology and Biotechnology: 2018. pp 17 (OP05)

Association of TP53 mutations and p53 protein expression in a cohort of Sri Lankan head and neck cancer patients

Local Communications
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, Angunawela P,De Silva K, Lunec J.
Publication year: 2018

Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, Angunawela P,De Silva K, Lunec J. Association of TP53 mutations and p53 protein expression in a cohort of Sri Lankan head and neck cancer patients. Proceedings of the 10th Annual Scientific Sessions, Institute of Biochemistry, Molecular Biology and Biotechnology: 2018. pp 17 (OP03)

Somatic mutations in the TP53 tumor suppressor gene in Sri Lankan patients with Head and Neck cancer

International Communications
Vahinipriya M, Karunanayake E, Tennekoon K, De Silva S, De Silva K, Angunawela P, Lunec J
Publication year: 2017

Vahinipriya M, Karunanayake E, Tennekoon K, De Silva S, De Silva K, Angunawela P, Lunec J. Somatic mutations in the TP53 tumor suppressor gene in Sri Lankan patients with Head and Neck cancer. Proceedings of the 3rd European Association for Cancer Research Conference on Cancer Genomics 2017. Cambridge, UK

 

Relationship between p53 immunohistochemistry staining pattern and TP53 gene mutation type in Sri Lankan patients with head and neck cancer

International Communications
Vahinipriya M, Karunanayake EH, Tennekoon KH, De Silva S, Angunawela P, De Silva K, Mahdi A, Zanjirband M, Lunec J
Publication year: 2017

Vahinipriya M, Karunanayake EH, Tennekoon KH, De Silva S, Angunawela P, De Silva K, Mahdi A, Zanjirband M, Lunec J. Relationship between p53 immunohistochemistry staining pattern and TP53 gene mutation type in Sri Lankan patients with head and neck cancer. North East Postgraduate Conference 2017, Newcastle, UK.

 

Pathogenic and possibly pathogenic genetic alterations of the GH1 and GHRHR genes detected in a cohort of IGHD children in Sri Lanka

International Communications
Sundralingam T, Tennekoon KH, De Silva KSH, De Silva S, Hewage AS
Publication year: 2017

Sundralingam T, Tennekoon KH, De Silva KSH, De Silva S, Hewage AS. Pathogenic and possibly pathogenic genetic alterations of the GH1 and GHRHR genes detected in a cohort of IGHD children in Sri Lanka. Proceedings of the European Human Genetics Conference 2017;Copenhagen, Denmark

Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka

Publication
Sundralingam T, Tennekoon KH, De Silva KSH, De Silva S, Hewage AS
Publication year: 2017

Sundralingam T, Tennekoon KH, De Silva KSH, De Silva S, Hewage AS. Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka. Growth Hormone & IGF Research, 2017; 36: 22–29. Doi: http://dx.doi.org/10.1016/j.ghir.2017.08.006

 

Novel variants of GHRHR gene observed in a cohort of isolated growth hormone deficient children in Sri Lanka

Local Communications
Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS
Publication year: 2017

Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS. Novel variants of GHRHR gene observed in a cohort of isolated growth hormone deficient children in Sri Lanka. Proceedings of the 130th Anniversary International Medical Congress of the Sri Lanka Medical Association; 2017. pp 163 (PP063)

Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients

Publication
De Silva, S, Tennekoon, KH, Dissanayake, A, De Silva K, Jayasekera L
Publication year: 2017

De Silva, S, Tennekoon, KH, Dissanayake, A, De Silva K, Jayasekera L. Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients. Familial Cancer. 2017; 16(3): 329–338. Doi: 10.1007/s10689-016-9962-9

GHRHR gene variants observed in combination of IGHD children in Sri Lanka

Local Communications
Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS
Publication year: 2017

Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS. GHRHR gene variants observed in combination of IGHD children in Sri Lanka. Proceedings of the 9th Annual Scientific Sessions, Institute of Biochemistry, Molecular Biology and Biotechnology: 2017. pp 13 (OP 02)

Detection of pathogenic mutations in hotspot regions in exon 11 of BRCA1 gene in a cohort of Sri Lankan young familial breast cancer patients

Local Communications
Jayasundara GP, De Silva S, De Silva, K
Publication year: 2017

Jayasundara GP, De Silva S, De Silva, K. Detection of pathogenic mutations in hotspot regions in exon 11 of BRCA1 gene in a cohort of Sri Lankan young familial breast cancer patients. Proceedings of the 9th Annual Scientific Sessions, Institute of Biochemistry, Molecular Biology and Biotechnology: 2017. pp 29 (PP 01)

Detection of IGF-II 820G>A polymorphism in a group of Sri Lankan women in endometriosis

Local Communications
Silva N, de Silva S, Jayawardene G, Senanayake H
Publication year: 2017

Silva N, de Silva S, Jayawardene G, Senanayake H. Detection of IGF-II 820G>A polymorphism in a group of Sri Lankan women in endometriosis. Proceedings of the Scientific Sessions, Faculty of Sciences, university of Sri Jayawardenapura: 2017. pp 71 (PP 30)

Cytotoxic potential of the RG7388 MDM2-p53 binding antagonist and the GSK2830371 WIP1 inhibitor on MX- 1 and MCF-7 human breast cancer cells

Published Abstracts
Manoharan V, Lunec J, Esfandiari A, Mahdi A, Wu C-E, Zanjirband M, Karunanayake EH, Tennekoon KH, De Silva S
Publication year: 2017

Manoharan V, Lunec J, Esfandiari A, Mahdi A, Wu C-E, Zanjirband M, Karunanayake EH, Tennekoon KH, De Silva S. Cytotoxic potential of the RG7388 MDM2-p53 binding antagonist and the GSK2830371 WIP1 inhibitor on MX- 1 and MCF-7 human breast cancer cells [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA):  AACR;  Cancer Res  2017;77(4  Suppl). Doi: 10.1158/1538-7445

pilot study on CYP21 gene deletions among a cohort of Sri Lankan children with congenital adrenal hyperplasia

Publication
Jayathilaka D K, Tennekoon K H, de Silva KSH, De Silva S
Publication year: 2017

Jayathilaka D K, Tennekoon K H, de Silva KSH, De Silva S. A pilot study on CYP21 gene deletions among a cohort of Sri Lankan children with congenital adrenal hyperplasia, Ceylon Medical Journal, 2017; 62(2); 112–113. Doi: http://doi.org/10.4038/cmj.v62i2.8479

Sequence variants in the promoter region of GH1 gene in a cohort of growth hormone deficient (GHD) children in Sri Lanka

Local Communications
Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS
Publication year: 2016

Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS. Sequence variants in the promoter region of GH1 gene in a cohort of growth hormone deficient (GHD) children in Sri Lanka. Proceedings of the 8th Annual Scientific Sessions, Institute of Biochemistry, Molecular Biology and Biotechnology: 2016. pp 27 (0P 16)

Screening of selected Sri Lankan cancer patients for somatic mutation of TP53 gene

Local Communications
Vahinipriya M , De Silva S, Karunanayake EH, Tennekoon KH, De Silva K
Publication year: 2016

Vahinipriya M , De Silva S, Karunanayake EH, Tennekoon KH, De Silva K. Screening of selected Sri Lankan cancer patients for somatic mutation of TP53 gene. Proceedings of the 8th Annual Scientific Sessions, Institute of Biochemistry, Molecular Biology and Biotechnology: 2016. pp 23 (0P 12)

Growth hormone releasing hormone receptor codon 72 mutation in a cohort of Sri Lankan patients with growth hormone deficiency

Publication
de Silva K S H, Tennekoon K H, Sundralingam T, Navarathne B, Hewage A S, de Silva WS, Ganihigama D, Jayasinghe H D, Muhandiram M E C
Publication year: 2016

de Silva K S H, Tennekoon K H, Sundralingam T, Navarathne B, Hewage A S, de Silva WS, Ganihigama D, Jayasinghe H D, Muhandiram M E C. Growth hormone releasing hormone receptor codon 72 mutation in a cohort of Sri Lankan patients with growth hormone deficiency. Ceylon Medical Journal. 2016; 61(1): 18–21.

Doi: http://doi.org/10.4038/cmj.v61i1.8257

Gross growth hormone deletions in a cohort of isolated growth hormone deficient children in Sri Lanka

Local Communications
Sundralingam T, Tennekoon KH, de Silva KSH, Hewage AS, De Silva S
Publication year: 2016

Sundralingam T, Tennekoon KH, de Silva KSH, Hewage AS, De Silva S. Gross growth hormone deletions in a cohort of isolated growth hormone deficient children in Sri Lanka. Proceedings of the 129th Anniversary International Medical Congress of the Sri Lanka Medical Association; 2016. pp 142 (OP067)

Association of BRCA2 N372H polymorphism with the risk of early onset of breast cancer in a cohort of Sri Lankan breast cancer patients

International Communications
Gamage R, De Silva S, De Silva K, Dissanayake A, Jayasekara L
Publication year: 2016

Gamage R, De Silva S, De Silva K, Dissanayake A, Jayasekara L. Association of BRCA2 N372H polymorphism with the risk of early onset of breast cancer in a cohort of Sri Lankan breast cancer patients. Proceedings of the 17th World Congress of Gynecological Endocrinology; 2016; Florence, Italy.

A pilot study on CYP21 gene deletion among a cohort of Sri Lankan children with congenital adrenal hyperplasia

Local Communications
Jayathilaka DK, Tennekoon KH, de Silva KSH, De Silva S
Publication year: 2016

Jayathilaka DK, Tennekoon KH, de Silva KSH, De Silva S. A pilot study on CYP21 gene deletion among a cohort of Sri Lankan children with congenital adrenal hyperplasia. Proceedings of the 129th Anniversary International Medical Congress of the Sri Lanka Medical Association; 2016. pp 142 (OP065)

Screening of a cohort of young onset Breast cancer patients for c.2175_2176insA mutation in the BRCA2 gene

Local Communications
Jayasekera BMLP, De Silva WS, Tennekoon KH, De Silva K, Dissanayake A
Publication year: 2015

Jayasekera BMLP, De Silva WS, Tennekoon KH, De Silva K, Dissanayake A. Screening of a cohort of young onset Breast cancer patients for c.2175_2176insA mutation in the BRCA2 gene. Proceedings of the 7th Annual Scientific Sessions, Institute of Biochemistry, Molecular Biology and Biotechnology: 2015. pp 32 (PP 05)

 

GH1 gene sequence variants in a cohort of growth hormone deficient children in Sri Lanka

International Communications
Sundralingam T, Tennekoon KH, De Silva KSH, De Silva S, Hewage AS.
Publication year: 2015

Sundralingam T, Tennekoon KH, De Silva KSH, De Silva S, Hewage AS. GH1 gene sequence variants in a cohort of growth hormone deficient children in Sri Lanka. Proceedings of the Regional Conference of Young Scientists on Nanoscience & Nanomaterial; 2015; Bengaluru, India.

GH1 gene alterations in a cohort of growth deficient children in Sri Lanka

Local Communications
Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS
Publication year: 2015

Sundralingam T, Tennekoon KH, de Silva KSH, De Silva S, Hewage AS. GH1 gene alterations in a cohort of growth deficient children in Sri Lanka. Proceedings of 128th Anniversary International Medical Congress of the Sri Lanka Medical Association: 2015 pp 142 (OP047)

Association of pathogenic mutations in BRCA2 exon 11 with early onset breast cancer in Sri Lankan population

International Communications
De Silva S, Tennekoon KH, Dissanayake A, De Silva K, Jayasekara L, Manoharan V
Publication year: 2015

De Silva S, Tennekoon KH, Dissanayake A, De Silva K, Jayasekara L, Manoharan V. Association of pathogenic mutations in BRCA2 exon 11 with early onset breast cancer in Sri Lankan population. Proceedings of AACR: New Horizons in Cancer Research Conference; 2015: Shanghai, China

Prevalence of missense mutation c.865A>C in BRCA2 gene in a cohort of Sri Lankan breast cancer patients.

Local Communications
De Silva S, Tennekoon KH, Karunanyake EH
Publication year: 2014

De Silva S, Tennekoon KH, Karunanyake EH. Prevalence of missense mutation c.865A>C in BRCA2 gene in a cohort of Sri Lankan breast cancer patients. Proceedings of the 02nd International Conference on Frontiers in Molecular Life Sciences, Institute of Biochemistry, Molecular Biology and Biotechnology: 2014. pp 35 (OP 02)

Optimization of DNA extraction from paraffin embedded tissues and preliminary analysis of somatic mutation of TP53 in breast cancer

Local Communications
Vahinipriya M , Tennekoon KH , Angunawela P , De Silva S
Publication year: 2014

Vahinipriya M , Tennekoon KH , Angunawela P , De Silva S. Optimization of DNA extraction from paraffin embedded tissues and preliminary analysis of somatic mutation of TP53 in breast cancer. Proceedings of 127th Anniversary International Medical Congress of the Sri Lanka Medical Association. 2014

GH1gene sequence variants in a cohort of Sri Lankan children with short stature

Local Communications
Sundralingam T, De Silva S, Hewage AS, De Silva KSH, Tennekoon KH
Publication year: 2014

Sundralingam T, De Silva S, Hewage AS, De Silva KSH, Tennekoon KH. GH1gene sequence variants in a cohort of Sri Lankan children with short stature. Proceedings of the 02nd International Conference on Frontiers in Molecular Life Sciences, Institute of Biochemistry, Molecular Biology and Biotechnology: 2014. pp 35 (OP 04)

Establishment of DNA extraction from paraffin embedded tissues and preliminary analysis of somatic mutation of TP53 in breast cancer

Local Communications
Vahinipriya M , Tennekoon KH , Angunawela P , De Silva S
Publication year: 2014

Vahinipriya M , Tennekoon KH , Angunawela P , De Silva S. Establishment of DNA extraction from paraffin embedded tissues and preliminary analysis of somatic mutation of TP53 in breast cancer. Proceedings of the 02nd International conference on Frontiers in Molecular Life Sciences, Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo. 2014. pp 48 (PP 01)