Prof. Kamani Hemamala Tennekoon
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
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Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED (2017) Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S76-S83. doi: 10.4103/0973-1296.203989. Epub 2017 Apr 7
Anti-hepatocarcinogenic and anti-oxidant effects of mangrove plant Scyphiphora hydrophyllacea
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED (2017) Anti-hepatocarcinogenic and anti-oxidant effects of mangrove plant Scyphiphora hydrophyllacea. Pharmacognosy magazine 13: Suppl 1, S 7
A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O--L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells
Samarakoon SR, Ediriweera MK, Nwokwu CDU, Bandara CJ, Tennekoon KH, Piyathilaka P, Karunaratne D, Karunaratne V (2017). A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O–L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells. BioMed Research International, Volume 2017 Article ID 9854083, https://doi.org/10.1155/2017/9854083
A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)
Ediriweera MK, Tennekoon KH, Samarakoon SR. (2017) A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango). Evid Based Complement Alternat Med. 2017;2017:6949835. doi: 10.1155/2017/6949835. Epub 2017 Dec 31
A pilot study on CYP21 gene deletions among a cohort of Sri Lankan children with congenital adrenal hyperplasia
Jayathilaka DK, Tennekoon KH, de Silva KSH, De Silva S. (2017) A pilot study on CYP21 gene deletions among a cohort of Sri Lankan children with congenital adrenal hyperplasia, Ceylon Medical Journal Jun 30;62:112-113
Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew (2016) Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells. European Journal of Medicinal Plants, ISSN: 2231-0894,Vol.: 14, Issue.: 4 DOI : 9734/EJMP/2016/26107
Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro
Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED. (2016) Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro.Exp Parasitol. 2016 May 10;167:50-60. doi: 10.1016/j.exppara.2016.05.002. [Epub ahead of print
New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells. J Ethnopharmacol
Ediriweera MK, Tennekoon KH, Adhikari A, Samarakoon SR, Thabrew I, de Silva ED (2016) New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells. J Ethnopharmacol. 2016 May 17. pii: S0378-8741(16)30314-2. doi: 10.1016/j.jep.2016.05.047. [Epub ahead of print]
Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties
Samarakoon SR, Fernando N, Ediriweera MK, Adhikari A, Wijayabandara L, de Silva ED, Tennekoon KH (2016) Isolation of Hopenone-I from the Leaves of Mangrove Plant Scyphiphora hydrophyllacea and Its Cytotoxic Properties. British Journal of Pharmaceutical Research, ISSN: 2231-2919,Vol.: 10, Issue.: 1 DOI : 10.9734/BJPR/2016/23317
Induction of Apoptosis in MCF-7 Breast Cancer Cells by Sri Lankan Endemic Mango (Mangifera zeylanica) Fruit Peel through Oxidative Stress and Analysis of its Phytochemical Constituents
Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. (2016) Induction of Apoptosis in MCF-7 Breast Cancer Cells by Sri Lankan Endemic Mango (Mangifera zeylanica) Fruit Peel through Oxidative Stress and Analysis of its Phytochemical Constituents. J Food Biochemistry 28 MAY 2016 DOI: 10.1111/jfbc.12294
In vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant, Phoenix paludosa Roxb
SR Samarakoon, C Shanmuganathan, MK Ediriweera, KH Tennekoon, Poorna Piyathilaka, Ira Thabrew, E Dilip de Silva (2016) In vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant, Phoenix paludosa Roxb. Tropical Journal of Pharmaceutical Research 15: 127-132
Growth hormone releasing hormone receptor codon 72 mutation in a cohort of Sri Lankan patients with growth hormone deficiency.
de Silva KS, Tennekoon KH, Sundralingam T, Navarathne B, Hewage AS, Hewage AS, de Silva WS, Ganihigama D, Jayasinghe HD, Muhandiram ME. (2016) Growth hormone releasing hormone receptor codon 72 mutation in a cohort of Sri Lankan patients with growth hormone deficiency. Ceylon Med J. 2016 Mar;61(1):18-21
Evaluation of selected natural compounds for cancer stem cells targeted anti-cancer activity: a molecular docking study
Mayan K, Samarakoon SR, Tennekoon KH, Siriwardana A, Valverde JR (2016) Evaluation of selected natural compounds for cancer stem cells targeted anti-cancer activity: a molecular docking study. European Journal of Medicinal Plants 15: 1-21
Cytotoxic, Antioxidant and Apoptotic Effects of Twenty Sri Lankan Endemic Plants in Breast Cancer Cells. European Journal of Medicinal Plants
Jayarathna PP, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, de Silva ED, Ediriweera MK (2016) Cytotoxic, Antioxidant and Apoptotic Effects of Twenty Sri Lankan Endemic Plants in Breast Cancer Cells. European Journal of Medicinal Plants, : 15, Issue.: 1 DOI : 10.9734/EJMP/2016/26591
Cytotoxic and apoptotic effects of the bark of two common mango (Mangifera indica) varieties from Sri Lanka on breast and ovarian cancer cells
Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. (2016) Cytotoxic and apoptotic effects of the bark of two common mango (Mangifera indica) varieties from Sri Lanka on breast and ovarian cancer cells. Br J Pharmaceutical Research DOI :9734/BJPR/2016/24004
A study on potential anticancer activity of Mangifera zeylanica bark: Evaluation of the cytotoxic and apoptotic effects of the hexane extract and bioassay guided fractionation to identify phytochemical constituents
Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. (2016). A study on potential anticancer activity of Mangifera zeylanica bark: Evaluation of the cytotoxic and apoptotic effects of the hexane extract and bioassay guided fractionation to identify phytochemical constituents. Oncology Letters 11: 1335-1344
Pseudophilautus dilmah, a new species of shrub frog (Amphibia: Anura: Rhacophoridae) from a threatened habitat Loolkandura in Sri Lanka
Wickramasinghe LJM,. Bandara IN, Vidanapathirana DR, Tennekoon KH, Samarakoon SR, Wickramasinghe N. 2015. Pseudophilautus dilmah, a new species of shrub frog (Amphibia: Anura: Rhacophoridae) from a threatened habitat Loolkandura in Sri Lanka. Journal of Threatened Taxa 7(5): 7089-110
Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes
Mendis AS, Thabrew I, Samarakoon SR, Tennekoon KH. Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes. BMC Complement Altern Med. 2015 Nov 9;15(1):404
Microcystin LR induced cytotoxicity and apoptosis on human embryonic kidney (HEK 293) and human kidney adenocarcinoma (ACHN) cell lines
Piyathilaka MAPC, Pathmalal MM, Tennekoon KH,Samarakoon SR, Chanthirika S, and de Silva BGDNK. 2015. Microcystin LR induced cytotoxicity and apoptosis on human embryonic kidney (HEK 293) and human kidney adenocarcinoma (ACHN) cell lines. Microbiology, 29th Januray 2015. 161 (Pt 4), 819-828
H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight.
Hewage AS, Jayanthiny P, Tennekoon KH, Kumarasiri JM, De S Wijesundere AP, Karunanayake EH. H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight. Endocrine 2015; 48(3):1010-2. doi: 10.1007/s12020-014-0402-z
A study of genetic polymorphisms in mitochondrial DNA hypervariable regions I and II of the five major ethnic groups and Vedda population in Sri Lanka
Ranasinghe R, Tennekoon KH, Karunanayake EH, Lembring M, Allen M. 2015 A study of genetic polymorphisms in mitochondrial DNA hypervariable regions I and II of the five major ethnic groups and Vedda population in Sri Lanka. Leg Med (Tokyo). 2015 May 27. pii: S1344-6223(15)00069-3. doi: 10.1016/j. legalmed.2015.05.007
In silico characterization of a RNA binding protein of cattle filarial parasite Setaria digitata
Nagaratnam N, Karunanayake EH, Tennekoon KH, Samarakoon SR, Mayan K. (2014) In silico characterization of a RNA binding protein of cattle filarial parasite Setaria digitata. Bioinformation. 2014 Aug 30;10(8):512-517
H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight
Hewage AS, Jayanthiny P, Tennekoon KH, Kumarasiri JM, Wijesundere AP, Karunanayake EH. (2014) H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight. Endocrine. 2014 Aug 31
Cytotoxic and apoptic effect of the decoction of the aerial parts of Flueggea leucopyrus on human endometrial carcinoma (AN3CA) cells
Samarakoon SR, Kotigala SB, Gammana-Liyanage I, Thabrew MI, Tennekoon KH, Siriwardena A, Galhena BP. (2014) Cytotoxic and apoptic effect of the decoction of the aerial parts of Flueggea leucopyrus on human endometrial carcinoma (AN3CA) cells . Tropical Journal of Pharmaceutical Research June 2014 13: 6
Association of Cord Blood Leptin, Soluble Leptin Receptor, Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-1 on Birth Indices in Healthy Full-Term Newborns
- Tennekoon KH, Poopalapillai J, Karunanayake AG, Jayasinghe HD, Kumarasiri JM, De S Wijesundera AP, Karunanayake EH (2014) Association of Cord Blood Leptin, Soluble Leptin Receptor, Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-1 on Birth Indices in Healthy Full-Term Newborns. Horm Res Paediatr. 81: 232-238
Analysis of BRCA1and BRCA2 large genomic rearrangements in Sri Lankan familial breast cancer patients and at risk individuals
De Silva S, Tennekoon KH, Karunanayake EH, Amarasinghe I, Angunawela P. (2014) Analysis of BRCA1and BRCA2 large genomic rearrangements in Sri Lankan familial breast cancer patients and at risk individuals. BMC Res Notes. 2014 Jun 6;7(1):344
Metalloestrogen cadmium stimulates proliferation of stromal cells derived from eutopic endometrium of women with endometriosis
Silva NY, TENNEKOON K, Senanayake H, Samarakoon S (2013) Metalloestrogen cadmium stimulates proliferation of stromal cells derived from eutopic endometrium of women with endometriosis. Taiwan J Obstet Gynecol. 52, 540-545
Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction with anti- hepatocarcinogenic effects
Samarakoon S, Thabrew I, Tennekoon K (2012) Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction with anti- hepatocarcinogenic effects. BMC Complementary and Alternative Medicine-, 12:25
LEPR c.668A>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia / pregnancy induced hypertension: a case control study
Tennekoon KH, Indika WL, Sugathadasa R, Karunanayake EH, Kumarasiri J, Wijesundera A (2012) LEPR c.668A>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia / pregnancy induced hypertension: a case control study. BMC Research Notes 5: 308
Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis
Samarakoon SR, Thabrew I, Galhena PB, Tennekoon KH (2012) Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis. Tropical Journal of Pharmaceutical research 11 (1): 51-61