The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites

Journal Paper
Kanchana S Senanayake, Jonas Söderberg, Aleksei Põlajev, Maja Malmberg, Eric H Karunanayake, Kamani H Tennekoon, Sameera R Samarakoon, Erik Bongcam-Rudloff, Adnan Niazi
Publication year: 2021

The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites
Kanchana S Senanayake, Jonas Söderberg, Aleksei Põlajev, Maja Malmberg, Eric H Karunanayake, Kamani H Tennekoon, Sameera R Samarakoon, Erik Bongcam-Rudloff, Adnan Niazi
Genome biology and evolution 2020, 12 (2), 3971-3976. doi: 10.1093/gbe/evaa017

Identification of 3-O-α-L-arabinosyl oleanolic acid, a triterpenoid saponin, as a new breast cancer stem cell growth inhibitor

Journal Paper
Muthoni DK, Samarakoon SR, Piyathilaka PC, Rajagopalan U, Tennekoon KH, Ediriweera MK.
Publication year: 2021

Identification of 3-O-α-L-arabinosyl oleanolic acid, a triterpenoid saponin, as a new breast cancer stem cell growth inhibitor
Muthoni DK, Samarakoon SR, Piyathilaka PC, Rajagopalan U, Tennekoon KH, Ediriweera MK.
Natural Product Research 2021 Jun 1:1-4. doi: 10.1080/14786419.2021.1933971.

Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line MDA-MB-231.

Journal Paper
Colamba Pathiranage V, Lowe JN, Rajagopalan U, Ediriweera MK, Senathilake K, Piyathilaka P, Tennekoon KH, Samarakoon SR
Publication year: 2021

Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line MDA-MB-231.
Colamba Pathiranage V, Lowe JN, Rajagopalan U, Ediriweera MK, Senathilake K, Piyathilaka P, Tennekoon KH, Samarakoon SR. Nutr Cancer. 2021; 73(5):845-855. doi: 10.1080/01635581.2020.1773511.

Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients

Journal Paper
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, Imthikab AIA, De Silva K, Angunawela P, Vishwakula S, Lunec J
Publication year: 2020

Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, Imthikab AIA, De Silva K, Angunawela P, Vishwakula S, Lunec J
.BMC Cancer. 2020 Jan 30;20(1):72. doi: 10.1186/s12885-020-6573-5V

Evaluation of non coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity

Journal Paper
Tiphania Kotelawala J, Ranasinghe R, Rodrigo C, Tennekoon KH, Silva K.
Publication year: 2020

Evaluation of non coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity
Tiphania Kotelawala J, Ranasinghe R, Rodrigo C, Tennekoon KH, Silva K.
Biomedical Reports. 2020 Jun;12(6):339-347. doi: 10.3892/br.2020.1292.

Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells

Journal Paper
Pathiranage VC, Thabrew I, Samarakoon SR, Tennekoon KH, Rajagopalan U, Ediriweera MK
Publication year: 2020

Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells
Pathiranage VC, Thabrew I, Samarakoon SR, Tennekoon KH, Rajagopalan U, Ediriweera MK
.Journal of Integrative Medicine. 2020 May;18(3):242-252. doi: 10.1016/j.joim.2020.02.007.

Analysis of common genetic mutations in a cohort of Sri Lankan children with salt wasting form of Congenital Adrenal Hyperplasia

Journal Paper
P Somasundaram, A S Hewage, K S H de Silva, K H Tennekoon
Publication year: 2020

Analysis of common genetic mutations in a cohort of Sri Lankan children with salt wasting form of Congenital Adrenal Hyperplasia
P Somasundaram, A S Hewage, K S H de Silva, K H Tennekoon
Ceylon Medical Journal 2020, 65, 95-104

Vernolactone promotes apoptosis and autophagy in human teratocarcinomal (NTERA-2) cancer stem-like cells

Journal Paper
Abeysinghe NK, Thabrew I, Samarakoon SR, Ediriweera MK, Tennekoon KH, Pathiranage VPC, Mendis AS
Publication year: 2019

Vernolactone promotes apoptosis and autophagy in human teratocarcinomal (NTERA-2) cancer stem-like cells
Abeysinghe NK, Thabrew I, Samarakoon SR, Ediriweera MK, Tennekoon KH, Pathiranage VPC, Mendis AS
Stem cells international 2019 Dec 19;2019:6907893. doi: 10.1155/2019/6907893. eCollection 2019

Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR.
Publication year: 2019

Ediriweera MK, Tennekoon KH, Samarakoon SR. (2019) Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. Semin Cancer Biol. 2019 May 22. pii: S1044-579X(18)30177-9. doi: 10.1016/j.semcancer.2019.05.012. [Epub ahead of print] Review. PubMed PMID:31128298.

Overview of the genetic basis toward early detection of breast cancer

Journal Paper
De Silva S, Tennekoon KH, Karunanayake EH
Publication year: 2019

De Silva S, Tennekoon KH, Karunanayake EH. (2019) Overview of the genetic basis toward early detection of breast cancer. Breast Cancer (Dove Med Press). 2019 21;11:71-80.

Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer

Journal Paper
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J.
Publication year: 2019

Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J. (2019) Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer. Mol Med Rep. 2019 Apr;19:2781-2791.

 

Isolation of a New SesquiterpeneLactone From VernoniaZeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines

Journal Paper
Mendis AS, Thabrew MI, Ediriweera MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED
Publication year: 2019

Mendis AS, Thabrew I, Ediriweera MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED. (2019) Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines. Anticancer Agents Med Chem. 2019;19:410-424.

In-vitro assays and techniques utilized in anti-cancer drug discovery

Journal Paper
Ediriweera MK, Samarakoon SR, Tennekoon KH
Publication year: 2019

Ediriweera MK, Samarakoon SR, Tennekoon KH (2019) In-vitro assays and techniques utilized in anti-cancer drug discovery. J Applied Toxicology Aug 2. doi: 10.1002/jat.3658

In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery

Journal Paper
MK Ediriweera, KH Tennekoon, SR Samarakoon
Publication year: 2019

In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery
MK Ediriweera, KH Tennekoon, SR Samarakoon
Frontiers in Anti-Cancer Drug Discovery Volume 10 10, 43

Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR.
Publication year: 2019

Ediriweera MK, Tennekoon KH, Samarakoon SR. (2019) Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents. Drug Discov Today. 2019 Mar;24:685-702

Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines

Journal Paper
Rajagopalan U, Samarakoon S R, Tennekoon KH, Malavige N, de Silva ED
Publication year: 2018

Rajagopalan U, Samarakoon S R, Tennekoon KH, Malavige N, de Silva ED (2018) Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines. Tropical Journal of Pharmaceutical Research 17 (9), 1825-1832

Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency

Journal Paper
Sundralingam T , Tennekoon KH , de Silva S, De Silva S, Hewage S , i Ranasinghe R
Publication year: 2018

Sundralingam T , Tennekoon KH , de Silva S, De Silva S, Hewage S , i Ranasinghe R (2018) Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency. Available on line 22 Oct 2018

Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae)

Journal Paper
Samarakoon SR, Ediriweera MK, Wijayabandara L, Fernand N, Tharmarajah L, Tennekoon KH, Piyathilaka P, Adhikari A
Publication year: 2018

Samarakoon SR, Ediriweera MK, Wijayabandara L, Fernand N, Tharmarajah L, Tennekoon KH, Piyathilaka P, Adhikari A (2018). Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae). Tropical Journal of Pharmaceutical Research  17: 475-481

Cytotoxic and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall. roots on human breast cancer (MCF-7) cells

Journal Paper
Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige GN, Thabrew MI, and Shrestha RL
Publication year: 2018

Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige GN, Thabrew MI, and Shrestha RL (2018 ) Cytotoxic and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall. roots on human breast cancer (MCF-7) cells. BioMed Research International Jul 24;2018:3171348. doi: 10.1155/2018/3171348. eCollection 2018

Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves

Journal Paper
Ediriweera MK, Jayarathna P, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, Adhikari A
Publication year: 2018

Ediriweera MK, Jayarathna P, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, Adhikari A (2018) Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves. Phytochemistry Letters 24: 114-119

Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells.

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED
Publication year: 2017

Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. (2017) Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells. Medicines (Basel). 2017 Jul 26;4(3). pii: E56. doi: 10.3390/medicines4030056

Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka

Journal Paper
Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS
Publication year: 2017

Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS. (2017) Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka. Growth Horm IGF Res. 36:22-29

Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro

Journal Paper
Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED, Adhikari A.
Publication year: 2017

Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED, Adhikari A. (2017) Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro. Exp Parasitol. 177:13-21

Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients.

Journal Paper
De Silva S, Tennekoon KH, Dissanayake A, De Silva K, Jayasekara L.
Publication year: 2017

De Silva S, Tennekoon KH, Dissanayake A, De Silva K, Jayasekara L. (2017) Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients. Fam Cancer. 16:329-338

Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential

Journal Paper
Ediriweera MK, Tennekoon KH, Samarakoon SR, Adhikari A, Thabrew I, Dilip de Silva E.
Publication year: 2017

Ediriweera MK, Tennekoon KH, Samarakoon SR, Adhikari A, Thabrew I, Dilip de Silva E. (2017) Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential. Biomed Pharmacother. 89:194-200. doi: 10.1016/j.biopha.2017.01.176. [Epub ahead of print]

In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells

Journal Paper
Tharmarajah L , Samarakoon SR, Ediriweera MK,  Piyathilaka P, Tennekoon KH, Senathilake KS, Rajagopalan U, Galhena PB, Thabrew I
Publication year: 2017

Tharmarajah L , Samarakoon SR, Ediriweera MK,  Piyathilaka P, Tennekoon KH, Senathilake KS, Rajagopalan U, Galhena PB, Thabrew I (2017)  In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells. Biomed Research International 2017;2017:2413197. doi: 10.1155/2017/2413197. Epub 2017 Jun 7

CYP2D6 polymorphisms may predict occurrence of adverse effects to tamoxifen: a preliminary retrospective study

Journal Paper
Wickramage I, Tennekoon KH, Ariyaratne MA, Hewage AS, Sundralingam T
Publication year: 2017

Wickramage I, Tennekoon KH, Ariyaratne MA, Hewage AS, Sundralingam T. (2017) CYP2D6 polymorphisms may predict occurrence of adverse effects to tamoxifen: a preliminary retrospective study. Breast Cancer (Dove Med Press). 9:111-120. doi: 10.2147/BCTT.S126557

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer.

Journal Paper
Rodrigo C, Tennekoon KH, Karunanayake EH, De Silva K, Amarasinghe I, Wijayasiri A.
Publication year: 2017

Rodrigo C, Tennekoon KH, Karunanayake EH, De Silva K, Amarasinghe I, Wijayasiri A. (2017) Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. Endocr J. 64:393-401

Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line

Journal Paper
Nwokwu DUC, Samarakoon SR, Karunaratne DN, Katuvawila NP, Ediriweera MK, Tennekoon KH
Publication year: 2017

Nwokwu DUC, Samarakoon SR, Karunaratne DN, Katuvawila NP, Ediriweera MK, Tennekoon KH (2017) Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line. Drug Delivery Letters 7: 219-226

Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea

Journal Paper
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED
Publication year: 2017

Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED (2017) Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S76-S83. doi: 10.4103/0973-1296.203989. Epub 2017 Apr 7