The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites
Kanchana S Senanayake, Jonas Söderberg, Aleksei Põlajev, Maja Malmberg, Eric H Karunanayake, Kamani H Tennekoon, Sameera R Samarakoon, Erik Bongcam-Rudloff, Adnan Niazi
Genome biology and evolution 2020, 12 (2), 3971-3976. doi: 10.1093/gbe/evaa017
Identification of 3-O-α-L-arabinosyl oleanolic acid, a triterpenoid saponin, as a new breast cancer stem cell growth inhibitor
Muthoni DK, Samarakoon SR, Piyathilaka PC, Rajagopalan U, Tennekoon KH, Ediriweera MK.
Natural Product Research 2021 Jun 1:1-4. doi: 10.1080/14786419.2021.1933971.
Hexane Extract of Garcinia quaesita Fruits Induces Apoptosis in Breast Cancer Stem Cells Isolated from Triple Negative Breast Cancer Cell Line MDA-MB-231.
Colamba Pathiranage V, Lowe JN, Rajagopalan U, Ediriweera MK, Senathilake K, Piyathilaka P, Tennekoon KH, Samarakoon SR. Nutr Cancer. 2021; 73(5):845-855. doi: 10.1080/01635581.2020.1773511.
Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, Imthikab AIA, De Silva K, Angunawela P, Vishwakula S, Lunec J
.BMC Cancer. 2020 Jan 30;20(1):72. doi: 10.1186/s12885-020-6573-5V
Evaluation of non coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity
Tiphania Kotelawala J, Ranasinghe R, Rodrigo C, Tennekoon KH, Silva K.
Biomedical Reports. 2020 Jun;12(6):339-347. doi: 10.3892/br.2020.1292.
Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells
Pathiranage VC, Thabrew I, Samarakoon SR, Tennekoon KH, Rajagopalan U, Ediriweera MK
.Journal of Integrative Medicine. 2020 May;18(3):242-252. doi: 10.1016/j.joim.2020.02.007.
Analysis of common genetic mutations in a cohort of Sri Lankan children with salt wasting form of Congenital Adrenal Hyperplasia
P Somasundaram, A S Hewage, K S H de Silva, K H Tennekoon
Ceylon Medical Journal 2020, 65, 95-104
Vernolactone promotes apoptosis and autophagy in human teratocarcinomal (NTERA-2) cancer stem-like cells
Abeysinghe NK, Thabrew I, Samarakoon SR, Ediriweera MK, Tennekoon KH, Pathiranage VPC, Mendis AS
Stem cells international 2019 Dec 19;2019:6907893. doi: 10.1155/2019/6907893. eCollection 2019
Ediriweera MK, Tennekoon KH, Samarakoon SR. (2019) Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance. Semin Cancer Biol. 2019 May 22. pii: S1044-579X(18)30177-9. doi: 10.1016/j.semcancer.2019.05.012. [Epub ahead of print] Review. PubMed PMID:31128298.
De Silva S, Tennekoon KH, Karunanayake EH. (2019) Overview of the genetic basis toward early detection of breast cancer. Breast Cancer (Dove Med Press). 2019 21;11:71-80.
Manoharan V, Karunanayake EH, Tennekoon KH, De Silva S, De Silva K, Angunawela P, Lunec J. (2019) Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer. Mol Med Rep. 2019 Apr;19:2781-2791.
Mendis AS, Thabrew I, Ediriweera MK, Samarakoon SR, Tennekoon KH, Adhikari A, de Silva ED. (2019) Isolation of a New Sesquiterpene Lactone From Vernonia Zeylanica (L) Less and its Anti-Proliferative Effects in Breast Cancer Cell Lines. Anticancer Agents Med Chem. 2019;19:410-424.
Ediriweera MK, Samarakoon SR, Tennekoon KH (2019) In-vitro assays and techniques utilized in anti-cancer drug discovery. J Applied Toxicology Aug 2. doi: 10.1002/jat.3658
In-vitro Anti-Proliferative Assays and Techniques Used in Pre-Clinical Anti-Cancer Drug Discovery
MK Ediriweera, KH Tennekoon, SR Samarakoon
Frontiers in Anti-Cancer Drug Discovery Volume 10 10, 43
Ediriweera MK, Tennekoon KH, Samarakoon SR. (2019) Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents. Drug Discov Today. 2019 Mar;24:685-702
Rajagopalan U, Samarakoon S R, Tennekoon KH, Malavige N, de Silva ED (2018) Screening of five Sri Lankan endemic plants for anti-cancer effects on breast cancer stem cells isolated from MCF-7 and MDA-MB-231 cell lines. Tropical Journal of Pharmaceutical Research 17 (9), 1825-1832
Sundralingam T , Tennekoon KH , de Silva S, De Silva S, Hewage S , i Ranasinghe R (2018) Novel gross deletion at the GHRHR gene locus possibly mediated by Alu specific microhomology identified in a Sri Lankan patient with isolated growth hormone deficiency. Available on line 22 Oct 2018
Samarakoon SR, Ediriweera MK, Wijayabandara L, Fernand N, Tharmarajah L, Tennekoon KH, Piyathilaka P, Adhikari A (2018). Isolation of cytotoxic triterpenes from the mangrove plant, Scyphiphora hydrophyllacea CF Gaertn (Rubiaceae). Tropical Journal of Pharmaceutical Research 17: 475-481
Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige GN, Thabrew MI, and Shrestha RL (2018 ) Cytotoxic and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall. roots on human breast cancer (MCF-7) cells. BioMed Research International Jul 24;2018:3171348. doi: 10.1155/2018/3171348. eCollection 2018
Ediriweera MK, Jayarathna P, Tennekoon KH, Samarakoon SR, Thabrew I, Karunanayake EH, Adhikari A (2018) Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves. Phytochemistry Letters 24: 114-119
Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. (2017) Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells. Medicines (Basel). 2017 Jul 26;4(3). pii: E56. doi: 10.3390/medicines4030056
Sundralingam T, Tennekoon KH, de Silva S, De Silva S, Hewage AS. (2017) Pathogenic and likely pathogenic genetic alterations and polymorphisms in growth hormone gene (GH1) and growth hormone releasing hormone receptor gene (GHRHR) in a cohort of isolated growth hormone deficient (IGHD) children in Sri Lanka. Growth Horm IGF Res. 36:22-29
Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED, Adhikari A. (2017) Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro. Exp Parasitol. 177:13-21
De Silva S, Tennekoon KH, Dissanayake A, De Silva K, Jayasekara L. (2017) Novel and reported pathogenic variants in exon 11 of BRCA2 gene in a cohort of Sri Lankan young breast cancer patients. Fam Cancer. 16:329-338
Ediriweera MK, Tennekoon KH, Samarakoon SR, Adhikari A, Thabrew I, Dilip de Silva E. (2017) Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential. Biomed Pharmacother. 89:194-200. doi: 10.1016/j.biopha.2017.01.176. [Epub ahead of print]
Tharmarajah L , Samarakoon SR, Ediriweera MK, Piyathilaka P, Tennekoon KH, Senathilake KS, Rajagopalan U, Galhena PB, Thabrew I (2017) In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells. Biomed Research International 2017;2017:2413197. doi: 10.1155/2017/2413197. Epub 2017 Jun 7
Wickramage I, Tennekoon KH, Ariyaratne MA, Hewage AS, Sundralingam T. (2017) CYP2D6 polymorphisms may predict occurrence of adverse effects to tamoxifen: a preliminary retrospective study. Breast Cancer (Dove Med Press). 9:111-120. doi: 10.2147/BCTT.S126557
Rodrigo C, Tennekoon KH, Karunanayake EH, De Silva K, Amarasinghe I, Wijayasiri A. (2017) Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer. Endocr J. 64:393-401
Nwokwu DUC, Samarakoon SR, Karunaratne DN, Katuvawila NP, Ediriweera MK, Tennekoon KH (2017) Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line. Drug Delivery Letters 7: 219-226
Samarakoon SR, Shanmuganathan C, Ediriweera MK, Piyathilaka P, Tennekoon KH, Thabrew I, Galhena P, De Silva ED (2017) Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S76-S83. doi: 10.4103/0973-1296.203989. Epub 2017 Apr 7