Prof. Sameera R Samarakoon
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
Cytotoxicity against hepatocellular carcinoma cell line (HepG2) and antioxidant properties of Adenanthera bicolor extracts
Thusyanthan J, Wickramaratne NS, Samarakoon SR, Tennekoon KH and Thabrew MI. Cytotoxicity against hepatocellular carcinoma cell line (HepG2) and antioxidant properties of Adenanthera bicolor extracts. Asian Symposium on Medicinal Palnts, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018, pp: 221.
Cytotoxic activity of an endolichenic fungus, Xylaria psidii and isolation of active compound for NCI-H292 lung cancer cells
Sinhthujah S, Maduranga HAK, Samarakoon SR, Wichramarachchi S, Weerakoon G and Paranagama PA. Cytotoxic activity of an endolichenic fungus, Xylaria psidii and isolation of active compound for NCI-H292 lung cancer cells. Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI Colombo, Sri Lanka, 12-14th December 2018.
Compounds isolated from Garcinia zeylanica Roxb suppress the proliferation of breast cancer stem cells (OL 019)
Rajagopalan U, Samarakoon SR, Tennekoon KH, Adhikari A, Malavige GN, de Silva ED, Choudhary MI. Compounds isolated from Garcinia zeylanica Roxb suppress the proliferation of breast cancer stem cells (OL 019). Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018.
Cancer stem cells: A theraputic target of breast cancer
Sameera R Samarakoon. Cancer stem cells: A theraputic target of breast cancer. Keynote speech at International chemical congress organized by Nepal Chemical Society. March 8-10, 2018. Chitwan Nepal.
Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves
Ediriweera PMK, Jayarathna PP, Tennekoon KH, Samarakoon SR, , Thabrew I, Karunanayake EH, Adhikari A . Campnospermenone A, B and C, three new cytotoxic alkyl-hydroxycyclohexenones from Campnosperma zeylanica Thwaites leaves. Phytochemistry Letters. 24 (2018) 114-119.
Biochemical evidence for induction of apoptosis in Filarial parasites by an aqueous extract of Vernonia zeylanica
Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH. Biochemical evidence for induction of apoptosis in Filarial parasites by an aqueous extract of Vernonia zeylanica. Asian Symposium on Medicinal Plants, Spices and Other Natural Products XVI, Colombo, Sri Lanka, 12-14th December 2018, pp: 035.
Anti-proliferative activity and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall roots on human breast cancer (MCF-7) cells
Nivethika Sivakumaran, Sameera Ranganath Samarakoon*, Achyut Adhikari, Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Neelika Malavige, Ira Thabrew, Ram Lal (Swagat) shrestha. Anti-proliferative activity and apoptotic effects of govaniadine isolated from Corydalis govaniana Wall roots on human breast cancer (MCF-7) cells. Biomed Research International. 2018.
Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells
Meran Keshawa Ediriweera ,Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon, Ira Thabrew andE. Dilip de Silva. Protective Effects of Six Selected Dietary Compounds against Leptin-Induced Proliferation of Oestrogen Receptor Positive (MCF-7) Breast Cancer Cells. Medicines 2017, 4(3), 56; doi:10.3390/medicines4030056.
Protective Effect of a Polyherbal Aqueous Extract Comprised of Nigella sativa (Seeds), Hemidesmus indicus(Roots), and Smilax glabra (Rhizome) on Bleomycin Induced Cytogenetic Damage in Human Lymphocytes
Bandula Prasanna Galhena, S. S. R. Samarakoon, Myrtle Ira Thabrew,Solomon F. D. Paul, Venkatachalam Perumal, and Chinnadurai Mani. Protective Effect of a Polyherbal Aqueous Extract Comprised of Nigella sativa (Seeds), Hemidesmus indicus(Roots), and Smilax glabra (Rhizome) on Bleomycin Induced Cytogenetic Damage in Human Lymphocytes. Biomed Research International -2017;1-8.
Oleanolic acid from antifilarial triterpene saponins of dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro
KS Senathilake, EH Karunanayake, SR Samarakoon, KH Tennekoon, ED de Silva, A Adhikari. Oleanolic acid from antifilarial triterpene saponins of dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro. Experimental Parasitology, 2017.177; 13.21.
Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential
Ediriweera PMK, Tennekoon KH, , Samarakoon SR, Adhikari A, Thabrew I, de Silva ED Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential. Biomedicine & Pharmacotherapy- 2017.89, 194-200.
Induction of Apoptosis in Response to Improved Gedunin by Liposomal Nano-Encapsulation in Human Small-Cell Lung Cancer (NCI-H292) Cell Line
Nwokwu CD, Samarakoon SR*, Karunaratne DN, Pamunuwa KMGK, Katuvawila KANP, Ediriweera MK and Tennekoon KH. Induction of Apoptosis in Response to Improved Gedunin by Liposomal Nano-Encapsulation in Human Small-Cell Lung Cancer (NCI-H292) Cell Line. Tropical Journal of Pharmacutical research – 2017; 16 (9), 2079-2087.
Induction of apoptosis in MCF-7 breast cancer cells by Sri Lankanendemic mango (Mangifera zeylanica) fruit peel through oxidative stress and analysis of phytochemical constituents
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon, Ira Thabrew, E Dilip de Silva. Induction of apoptosis in MCF-7 breast cancer cells by Sri Lankanendemic mango (Mangifera zeylanica) fruit peel through oxidative stress and analysis of phytochemical constituents. Journal of Food Biochemistry– 2017.41;1. doi: 10.1111/jfbc.12294
In vitro anti cancer effect of gedunin on human teratocarcinomal (NTERA-2) cancer stem-like cells
Luxmiga Tharmarajah, Sameera Ranganath Samarakoon*, Meran Keshawa Ediriweera, Poorna Piyathilaka, Kamani Hemamamla Tennekoon, Kanishka Sithira Senathilake, Umapriyatharshini Rajagopalan, Prasanna Bandula Galhena, Ira Thabrew. In vitro anti cancer effect of gedunin on human teratocarcinomal (NTERA–2) cancer stem-like cells. Biomed Research International-2017. Article ID 2413197, 9 pages, 2017. doi:10.1155/2017/2413197.
Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line.
Chukwumaobim D.U. Nwokwu, Sameera R. Samarakoon, Desiree N. Karunaratne, Nuwanthi P. Katuvawila, Meran K. Ediriweera, Kamani H. Tennekoon. Chitosan Nano-encapsulation Enhances Gedunin Cytotoxicity A gainst Human Non-small-cell Lung Cancer (NCI-H292) Cell Line. Drug Delivery Letters.2017, 7, (3) 219-226.
Anti carcinogenic, and antioxidant f effects of mangrove plant Scyphiphora hydrophyllacea
Samarakoon SR*, Chanthirika S, Ediriweera PMK, Tennekoon KH, Thabrew MI , Piyathilaka MAPC and de Silva ED Anti carcinogenic, and antioxidant f effects of mangrove plant Scyphiphora hydrophyllacea– Pharmacognosy Magazine-2017; Suppl1 S76.
A traditional poly herbal preparation comprising of Vernonia zeylanica , Leucas zeylanica,and Acalypha indica induces oxidative stress and apoptosis in filarial parasite Setaria digitata
Senathilake KS, Karunanayake EH, Tennekoon KH, Samarakoon SR. A traditional poly herbal preparation comprising of Vernonia zeylanica , Leucas zeylanica,and Acalypha indica induces oxidative stress and apoptosis in filarial parasite Setaria digitata . Infectious Diseases: Biology to intervention stratergies. September 7-9, 2017, Bangalore.
A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O--L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells
Sameera R. Samarakoon*, Meran K. Ediriweera, Chukwumaobim Daniel Uzochukwuwulu Nwokwu, et al., “A Study on Cytotoxic and Apoptotic Potential of a Triterpenoid Saponin (3-O–L-Arabinosyl Oleanolic Acid) Isolated from Schumacheria castaneifolia Vahl in Human Non-Small-Cell Lung Cancer (NCI-H292) Cells,” BioMed Research International, vol. 2017, Article ID 9854083, 8 pages, 2017. doi:10.1155/2017/9854083
A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, and Sameera Ranganath Samarakoon. A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango). Evidence-Based Complementary and Alternative Medicine. Volume 2017 (2017), Article ID 6949835, 24 page
Screening of selected natural compounds for anti cancer activity regulated via induced differentiation on cancer stem cells (NT2)
Iromi HSPC, Samarakoon SR, Ediriweera MK, Adhikari A, Rajagopalan U, Tennekoon KH. Screening of selected natural compounds for anti cancer activity regulated via induced differentiation on cancer stem cells (NT2). 8th Annual Scientific Sessions 27st May, 2016. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells
Sameera R Samarakoon*, Chanthirika Shanmuganathan, Meran K Ediriweera, Poorna Piyathilaka, Kamani H Tennekoon, Ira Thabrew. Screening of Fifteen Mangrove Plants Found in Sri Lanka for in-vitro Cytotoxic Properties on Breast (MCF-7) and Hepatocellular Carcinoma (HepG2) Cells. European journal of medicinal plants. 2016.14.4.1-11.
Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro
Senathilake KS, Karunanayake EH, Samarakoon SR, Tennekoon KH, de Silva ED. Rhizome extracts of Curcuma zedoaria Rosc induce caspase dependant apoptosis via generation of reactive oxygen species in filarial parasite Setaria digitata in vitro. Experimental Parasitology2016.167;50-60. – doi:10.1016/j.exppara.2016.05.002
Preparation, characterization and in vitro anti proliferative studies of doxorubicin loaded chitosan and chitosan-alginate nanoparticles on MCF-7 cell line
K.A.N.P. Katuwavila, A.D.L.C.Perera, S.R. Samarakoon, S.S.S.B.D.P. Soysa, V.Karunaratne, G.A.J. Amaratunga, and D.N.Karunaratne. Preparation, characterization and in vitro anti proliferative studies of doxorubicin loaded chitosan and chitosan-alginate nanoparticles on MCF-7 cell line.- journal of Nanomaterials– 2016.Article ID 3178904.
Potential in vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant Phoenix paludosa Roxb
Samarakoon SR*, Chanthirika S. Tennekoon KH, Thabrew MI, Ediriweera PMK, Piyathilaka MAPC, de Silva ED. Potential in vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant Phoenix paludosa Roxb. Tropical Journal of Pharmaceutical Research – 2016; 15 (1): 127-132.
Possible mechanisms mediating anti-proliferating effects in breast cancer phenotypes by Vernonia zeylanica (less)
Mendis AS, Thabrew MI, Samarakoon S, Tennekoon KH. Possible mechanisms mediating anti-proliferating effects in breast cancer phenotypes by Vernonia zeylanica (less). 8th Annual Scientific Sessions 27st May, 2016. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
New halogenated compounds from Mangifera zeylanica, Sri Lankan endemic mango and their potential anticancer effects in breast and ovarian cancer cells
Ediriweera PMK, Tennekoon KH, Adhikari A, Samarakoon SR, Thabrew I, de Silva ED,. New halogenated compounds from Mangifera zeylanica, Sri Lankan endemic mango and their potential anticancer effects in breast and ovarian cancer cells –Journal of Ethnopharmacolgoy- 189 (2016) 165–174. (doi:10.1016/j.jep.2016.05.047).
Molecular docking study of selected natural compounds for cancer stem cells targeted anti-cancer activity
Karthika Mayan, Sameera Ranganath Samarakoon*, Kamani Hemamala Tennekoon, Asitha Siriwardana, José R Valverde. Molecular docking study of selected natural compounds for cancer stem cells targeted anti-cancer activity. European journal of medicinal plants. 2016. 15(4): 1-21
Induction of apoptosis in response to improved gedunin by liposomal nano-encapsulation in human small-cell lung cancer (NCI-H292) cell line
Nwokwu CDU, Samarakoon SR, Karunaratne DN, Katuvawila KANP, Pamunuwa KMGK, Ediriweera MK, Tennekoon KH. Induction of apoptosis in response to improved gedunin by liposomal nano-encapsulation in human small-cell lung cancer (NCI-H292) cell line. 8th Annual Scientific Sessions 27st May, 2016. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Cytotoxic, Antioxidant and Apoptotic Effects of Twenty Sri Lankan Endemic Plants in Breast Cancer Cells
Panchima P. Jayarathna , Kamani H. Tennekoon, Sameera R. Samarakoon , Ira Thabrew , Eric H. Karunanayake, E. Dilip de Silva and Meran K. Ediriweera. Cytotoxic, Antioxidant and Apoptotic Effects of Twenty Sri Lankan Endemic Plants in Breast Cancer Cells. European Journal of Medicinal Plants. 2016. 15(1): 1-15
Cytotoxic potential of new compounds isolated from Mangifera zeylanica on breast (MCF-7 and MDA-MB-231) and ovarian (SKOV-3) cancer cells
Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED, Adhikari A. Cytotoxic potential of new compounds isolated from Mangifera zeylanica on breast (MCF-7 and MDA-MB-231) and ovarian (SKOV-3) cancer cells. 8th Annual Scientific Sessions 27st May, 2016. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.