Prof. Sameera R Samarakoon
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
Effect of Flueggea leucopyrus willd. decoction on the proliferation and heat shock protein expression in three human breast cancer cell phenotypes
Anuka Mendis, M. Ira Thabrew, Sameera Samarakoon, Kamani Tennekoon. Effect of Flueggea leucopyrus willd. decoction on the proliferation and heat shock protein expression in three human breast cancer cell phenotypes: an in-vitro evaluation. 5th Asia Pacific ISSX Meeting, May 9-12, 2014. China.
Cytotoxicity and apoptotic effects of Microcystin-LR on human embryonic kidney (HEK 293) and human kidney adenocarcinoma (ACHN) cell lines
Piyathilaka M.A.P.C., Pathmalal M.M., Tennekoon K.H., De Silva B.G.D.N.K., Samarakoon S.S.R., and Chanthirika S. Cytotoxicity and apoptotic effects of Microcystin-LR on human embryonic kidney (HEK 293) and human kidney adenocarcinoma (ACHN) cell lines.- 19th North American ISSX Meeting / 29th JSSX Meeting, California, USA October 19 – 23, 2014.
Cytotoxic and apoptotic properties of the hexane extract of Mangifera zeylanica bark and identification of phytochemical profile
Ediriweera PMK, Tennekoon KH, Samarakoon SR, Thabrew I, de Silva ED. Cytotoxic and apoptotic properties of the hexane extract of Mangifera zeylanica bark and identification of phytochemical profile. 19th North American ISSX Meeting / 29th JSSX Meeting, California, USA October 19 – 23, 2014.
Comparative study of the cytotoxic effects of microcistin-LR and crude cyanotoxin extract from Beira Lake cyanobacteria on human embryonic kidney (HEK 293) cell line
Piyathilaka M.A.P.C, Pathmalal M.M., Tennekoon K.H., Samarakoon S.R., Chanthirika S.,2 De Silva B.G.D.N,K. Comparative study of the cytotoxic effects of microcistin-LR and crude cyanotoxin extract from Beira Lake cyanobacteria on human embryonic kidney (HEK 293) cell line. 2nd international conference on frontiers of Molecular Life Sciences. 11th -12th September, 2014. Colombo.
Antifilarial Activity of Curcuma zedoaria Against Adult Bovine Setaria digitata.
Senathilake KS, Samarakoon SR, Karunanayake EH, Tennekoon KH. Antifilarial Activity of Curcuma zedoaria Against Adult Bovine Setaria digitata. 2nd international conference on frontiers of Molecular Life Sciences. 11th -12th September, 2014. Colombo
Anti-carcinogenic effects of a standardized Flueggea leucopyrus (aerial parts) decoction on human endometrial carcinoma (AN3CA) cells
Sameera R Samarakoon*, Saman B Kotigala, Ishani Gammana-Liyanage, , Ira Thabrew, Kamani H Tennekoon Anti-carcinogenic effects of a standardized Flueggea leucopyrus (aerial parts) decoction on human endometrial carcinoma (AN3CA) cells. Tropical Journal of Pharmaceutical Research– 2014; 13 (6): 873-880.
Studies of Anti-hepatocarcinogenic Activity of Indigofera aspalathoides Extracts
Senthi Maaran S, de Silva ED, Thabrew MI, Ediriweera PMK, Samarakoon SR, Tennekoon KH. Studies of Anti-hepatocarcinogenic Activity of Indigofera aspalathoides Extracts. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis
Nalinda Silva, Kamani Tennekoon, Hemantha Senanayake, Sameera Samarakoon. Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis. Taiwan Association of Obstetrics and Gynecology. 2013, 52: 540-545.
Kalopanaxsaponin I containing fraction isolated from a standardized decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes exerts cytotoxic and apoptotic effects on HepG2 cells
Sameera R Samarakoon, Ira Thabrew, Kamani H Tennekoon, E Dilip de Silva, Iqbal Choudhary. Kalopanaxsaponin I containing fraction isolated from a standardized decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes exerts cytotoxic and apoptotic effects on HepG2 cells. World congress on pharmaceutical science and chemical technology 16th-18th December 2013. Colombo, Sri Lanka.
Isolation of an anti-hepatocarcinogenic active compound from Indigofera aspalathoides extracts
Senthi Maaran S, de Silva ED, Thabrew MI, Ediriweera PMK, Samarakoon SR, Tennekoon KH. Isolation of an anti-hepatocarcinogenic active compound from Indigofera aspalathoides extracts. Proceeding of the Sri Lanka Association for the Advancement of Science. 2013.
In silico characterization of Bax Inhibitor 1 like domain containing Endoplasmic Reticulum transmembrane protein of filarial parasite Setaria digitata
Mendis VEN, Senathilake KS, Samarakoon SR, Karunanayake EH. In silico characterization of Bax Inhibitor 1 like domain containing Endoplasmic Reticulum transmembrane protein of filarial parasite Setaria digitata. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Evaluation of the cytotoxic and apoptotic enhancing effects of a methanolic extract of Mangifera zeylanica bark in human hepatoma (HepG2) cells
Mendis AS, Samarakoon SR, Thabrew MI. Evaluation of the cytotoxic and apoptotic enhancing effects of a methanolic extract of Mangifera zeylanica bark in human hepatoma (HepG2) cells. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Evaluation of the cytotoxic activity of Flueggea leucopyrus (Willd) fractions on Human Breast cancer (MCF-7) cells
Mendis AS, Ediriweera PMK, Samarakoon SR, Thabrew MI. Evaluation of the cytotoxic activity of Flueggea leucopyrus (Willd) fractions on Human Breast cancer (MCF-7) cells. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Evaluation of antifilarial activity of Wild Ginger against adult bovine Setaria digitata
Senathilake KS, Samarakoon SR, Karunanayake EH, Tennekoon KHT, de Silva ED. Evaluation of antifilarial activity of Wild Ginger against adult bovine Setaria digitata. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Development of multiplex RT-PCR for detection of Bax, Survivin and p53 expression in MCF-7 breast cancer cell line
Chanthirika S, Samarakoon SR, Ediriweera PMK, Weerasena OVDSJ. Development of multiplex RT-PCR for detection of Bax, Survivin and p53 expression in MCF-7 breast cancer cell line. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Cytotoxic effect of Mangifera zeylanica bark in human breast cancer cell line MCF-7
Ediriweera PMK, Tennekoon KHT, Samarakoon SR, Thabrew MI, de Silva ED. Cytotoxic effect of Mangifera zeylanica bark in human breast cancer cell line MCF-7. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Cytotoxic and apoptotic effects of Lumnitzera littorea leaves on human hepatocellular carcinoma (HepG2) cells
Chanthirika S, Samarakoon SR, Tennekoon KHT, Thabrew MI, Ediriweera PMK. Cytotoxic and apoptotic effects of Lumnitzera littorea leaves on human hepatocellular carcinoma (HepG2) cells. 6th Annual Scientific Sessions 3rd May, 2013. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka.
Physicochemical, functional and structural characterization of Yip1 domain containing Golgi membrane protein from filarial parasite Setaria digitata
Senathilake KS, Samarakoon SR, Karunanayake EH. Physicochemical, functional and structural characterization of Yip1 domain containing Golgi membrane protein from filarial parasite Setaria digitata. Abstract of 5th Annual Scientific Sessions, 2012, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri Lanka
Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction with anti- hepatocarcinogenic effects
Sameera Samarakoon*, Ira Thabrew, Kamani Tennekoon, Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction with anti- hepatocarcinogenic effects. BMC complementary and alternative medicine 2012, 12:25
Evaluation of anti-carcinogenic potential of Flueggea leucopyrus (Willd) in human hepatoma (HepG2 cells)
SR Samarakoon, I Thabrew, PB Galhena, KH Tennekoon. Evaluation of anti-carcinogenic potential of Flueggea leucopyrus (Willd) in human hepatoma (HepG2 cells). Sri Lanka Medical Association 125th Anniversary International Medical Congress, 2 to 6 July 2012. Bandaranaike Memorial International Conference Hall Colombo, Sri Lanka.
Establishment of human endometrial stromal cell cultures as in-vitro models to test the effects of metalloestrogens in women with or without endometriosis
N Silva, K Tennekoon, H Senanayake, S Samarakoon, S Fernando, R Wickramasinghe, RP John. Establishment of human endometrial stromal cell cultures as in-vitro models to test the effects of metalloestrogens in women with or without endometriosis. Sri Lanka Medical Association 125th Anniversary International Medical Congress, 2 to 6 July 2012. Bandaranaike Memorial International Conference Hall Colombo, Sri Lanka.
Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis
Sameera R. Samarakoon*, Ira Thabrew, Prasanna B. Galhena, Kamani H. Tennekoon. Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and livers of mice with chemically induced hepatocarcinogenesis. Tropical Journal of Pharmacutical research. 2012; 11 (1): 51-61.
Effect of a herbal extract on Bcl-2 and Bax expression in endometrial carcinoma cells
Ishani Gammana-Liyanage, Sameera R Samarakoon, Ira Thabrew,. Effect of a herbal extract on Bcl-2 and Bax expression in endometrial carcinoma cells. Abstract of 5th Annual Scientific Sessions, 2012, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri Lanka.
Effect of a decoction of flueggea leucopyrus on the expression of Caspase 3 and Caspase 9 in endometrial carcinoma cells
Saman B Kotigala, Ishani Gammana-Liyanage, Sameera R Samarakoon, Ira Thabrew, Kamani H Tennekoon. Effect of a decoction of flueggea leucopyrus on the expression of Caspase 3 and Caspase 9 in endometrial carcinoma cells. Abstract of 5th Annual Scientific Sessions, 2012, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri Lanka.
Cancer stem cells: implication for the treatment of cancer
Samarakoon SR, Thabrew I, Tennekoon KH. Cancer stem cells: implication for the treatment of cancer. Update presentation of 5th Annual Scientific Sessions, 2012, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri Lanka.
Association of metalloestrogen cadmium and endometriosis
Silva Nalinda, K Tennekoon, H Senanayake, S Samarakoon. Association of metalloestrogen cadmium and endometriosis. At the 15th World Congress of Gynaecological Endocrinology held from 7th to 10th March, 2012. In Florence, Italy.
Anti-proliferative effects of Mangifera zeylanica bark in human hepatoma (HepG2) cells
Samarakoon SR, Thabrew I, Galhena PB , Tennekoon KH. Anti-proliferative effects of Mangifera zeylanica bark in human hepatoma (HepG2) cells. Abstract of 5th Annual Scientific Sessions, 2012, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri Lanka.
Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (root), and Smilax glabra (rhizome) mediates its anti-hepatocarcinogenic effects. Evidence-Based Complementary and Alternative Medicine
Prasanna B Galhena, Sameera R Samarakoon, Ira M Thabrew, Mayuri G Thammitiyagodage, W. D Rathnasooriya, Kamani H Tennekoon. Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (root), and Smilax glabra (rhizome) mediates its anti-hepatocarcinogenic effects. Evidence-Based Complementary and Alternative Medicine. 2012; doi:10.1155/2012/108626.
Survivin gene expression in hepatocellular carcinoma cell line: optimization of PCR conditions and effect of a herbal decoction
Ratnayaka ARMNNK, Thabrew MI, Samarakoon SR, Survivin gene expression in hepatocellular carcinoma cell line: optimization of PCR conditions and effect of a herbal decoction. Abstract of 4th Annual Scientific Sessions, 2011, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri Lanka.
Standardized aqueous extract of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) induced apoptosis in human hepatocellular carcinoma (HepG2) cells via regulating Bax and Bcl-2 genes
Sameera R. Samarakoon, M. Ira Thabrew, Prasanna B. Galhena, Kamani H. Tennekoon, E. Dilip De Silva, Standardized aqueous extract of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) induced apoptosis in human hepatocellular carcinoma (HepG2) cells via regulating Bax and Bcl-2 genes. International Conference on Natural Products and Biomedical Technology January 2011, organized by the University of Annamalai, Tamil Nadu, India.