Professor Shiroma M Handunnetti
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
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Adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1: A marker of parasite virulence
Handunnetti SM, Pathirana PPSL, Howard RJ and Mendis KN. Adherence of Plasmodium falciparum-infected erythrocytes to ICAM-1: A marker of parasite virulence. Second Global Meet on Parasitic Diseases, 18th -22nd August, 1997; Hyderabad, India, pp 213-214
The models of human malaria: their use for evaluation of vaccine
Mendis KN, Perera KLRL, Handunnetti SM, Longacre S, The models of human malaria: their use for evaluation of vaccine. 7th International Congress for Infectious Diseases, Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, 10-13th June 1996; pp 311-312
Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites, and have implications for disease control
Handunnetti SM, Gunawardena DM, Pathirana PPSL, Ekanayake K, Weerasinghe S and Mendis KN. Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites, and have implications for disease control. Transactions of the Royal Society of Tropical Medicine & Hygeine, 1996; 90: 563-567
Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites and have implications for disease control
Handunnetti SM, Gunawardena DM, Pathirana PPSL, Ekanayake K, Weerasinghe S, Mendis KN. Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites and have implications for disease control. Third International Medical Congress, University of Peradeniya, 22- 25th August 1996; pp 38
ecrudescent chloroquine-resistant Plasmodium falciparum parasites have a survival advantage
Handunnetti SM, Gunawardene DM, Pathirana PPSL and Mendis KN. Recrudescent chloroquine-resistant Plasmodium falciparum parasites have a survival advantage. XIVth International Congress for Tropical Medicine and Malaria 17th -22nd Nov, 1996; Nagasaki, Japan, pp 169
Cytoadherence properties of P. falciparum-infected erythrocytes in relation to the severity of clinical disease and parasite density in uncomplicated malaria in Sri Lanka
Pathirana PPSL, Ekanayake K, Mendis KN and Handunnetti SM. Cytoadherence properties of falciparum-infected erythrocytes in relation to the severity of clinical disease and parasite density in uncomplicated malaria in Sri Lanka. Proceedings of the 52ndAnnual Sessions of the SLAAS, 1996; pp 26.
The development of a scoring system to assess the severity and complications of malaria
Alles HK, Jayasinghe S, De Silva D, Naotunne T, Handunnetti SM, Carter R, Sheriff R and Mendis KN. The development of a scoring system to assess the severity and complications of malaria. Proceedings of the 108thAnnual Academic Session of the Sri Lanka Medical Association, 1995; pp 28.
Sulphadoxine‑pyrimethamine and chloroquine resistant Plasmodium falciparum infection in Sri Lanka.
Handunnetti SM, Jayasinghe S, Pathirana PPSL, Fernando R, Sheriff MHR, and Mendis KN. Sulphadoxine‑pyrimethamine and chloroquine resistant Plasmodium falciparum infection in Sri Lanka. Ceylon Medical Journal, 1994; 39:45‑46
Enhancement of cytoadherence of Plasmodium falciparum infected erythrocytes to CD36 by malarial paroxysm plasma
Pathirana PPSL, Ekanayake K, Weerasinghe S, Alles HK, Carter R, Mendis KN, and Handunnetti SM. Enhancement of cytoadherence of Plasmodium falciparum‑infected erythrocytes to CD36 by malarial paroxysm plasma. Proceedings of the 49th Annual Sessions of SLAAS, 1994; pp 24-25
Immunochemical characterization and differentiation of two ~300 kDa erythrocyte membrane‑associated proteins of Plasmodium falciparum, PfEMP1 and PfEMP3
van Schravendijk MR, Pasloske BL, Baruch DI, Handunnetti SM, and Howard RJ. Immunochemical characterization and differentiation of two ~300 kDa erythrocyte membrane‑associated proteins of Plasmodium falciparum, PfEMP1 and PfEMP3. American Journal Tropical Medicine & Hygiene, 1993; 49:552‑565
Genetic heterogeneity of Plasmodial genes in Sri Lankan isolates as detected by the Polymerase Chain Reaction
Wattevidanage J, Perera KLRL, David PH, Carter R, Ranford‑Cartwright L, Kapilananda GM, Pathirana PPSL, Handunnetti SM, Mendis KN, and Premawansa WS. Genetic heterogeneity of Plasmodial genes in Sri Lankan isolates as detected by the Polymerase Chain Reaction. Proceedings of the 49th Annual Sessions of SLAAS, 1993; pp 20.
Drug resistance and clinical immunity in Plasmodium falciparum malaria infections among hospital admission in Colombo, Sri Lanka
Handunnetti SM, Pathirana PPSL, Ekanayake K, MGM Kapilananda, Perera KLRL, and Mendis KN. Drug resistance and clinical immunity in Plasmodium falciparum malaria infections among hospital admission in Colombo, Sri Lanka. Proceedings of the 49th Annual Sessions of SLAAS, 1993; pp 14.
Cloning and characterization of a Plasmodium falciparum gene encoding a novel high molecular weight host membrane associated protein PfEMP3
Pasloske BL, Baruch DI, van Schravendijk MR, Handunnetti SM, Aikawa M, Fujioka H, Taraschi TF, Gormley JA, and Howard RJ. Cloning and characterization of a Plasmodium falciparum gene encoding a novel high molecular weight host membrane associated protein PfEMP3. Molecular Biochemical Parasitology, 1993; 59:59‑72
Adherence properties of Sri Lankan Plasmodium falciparum isolates to endothelial cell receptor CD36
Pathirana PPSL, Ekanayake K, Perera KLRL, Howard RJ, Mendis KN, and Handunnetti SM. Adherence properties of Sri Lankan Plasmodium falciparum isolates to endothelial cell receptor CD36. Proceedings of the 49th Annual Sessions of SLAAS, 1993; pp 16-17.
The characterization of two monoclonal antibodies which react with high molecular weight antigens of asexual Plasmodium falciparum
Handunnetti SM, Pasloske BL, van Schravendijk MR, Aguiar JC, Taraschi TF, Gormley JA and Howard RJ.The characterization of two monoclonal antibodies which react with high molecular weight antigens of asexual Plasmodium falciparum. Molecular Biochemical Parasitology, 1992; 54:231‑246
Purification and invitro selection of rosette‑positive (R+) and rosette‑negative (R‑) phenotypes of knob‑positive Plasmodium falciparum parasites
Handunnetti SM, Gilladoga AD, van Schravendijk M‑R, Nakomura K, Aikawa M, and Howard RJ. Purification and invitro selection of rosette‑positive (R+) and rosette‑negative (R‑) phenotypes of knob‑positive Plasmodium falciparum parasites. American Journal Tropical Medicine & Hygiene, 1992; 46:371‑381
Plasmodium falciparum-infected erythrocytes do not adhere well to C32 melanoma cells or CD36 unless rosettes with uninfected erythrocytes are first disrupted
Handunnetti SM, Hasler TH, van Schravendijk M‑R, and Howard RJ.Plasmodium falciparum-infected erythrocytes do not adhere well to C32 melanoma cells or CD36 unless rosettes with uninfected erythrocytes are first disrupted. Infection & Immunity, 1992; 60:928‑932
Normal human erythrocytes express CD36, an adhesion molecule of monocytes, platelets, and endothelial cells
van Schravendijk MR, Handunnetti SM, Barnwell JW, and Howard RJ. Normal human erythrocytes express CD36, an adhesion molecule of monocytes, platelets, and endothelial cells. Blood, 1992; 80:2105‑2114
Involvement of CD36 on erythrocytes as a Rosetting receptor for Plasmodium falciparum‑infected erythrocytes
Handunnetti SM, van Schravendijk M‑R, Hasler TH, Barnwell JW, Greenwalt DE, and Howard RJ. Involvement of CD36 on erythrocytes as a Rosetting receptor for Plasmodium falciparum‑infected erythrocytes. Blood, 1992; 80:2097‑2104
In vitro rosetting and microagglutination properties of Plasmodium falciparum infected erythrocytes
Handunnetti SM, Pathirana PPSL, Ekanayake K, Howard RJ, and Mendis KN. In vitro rosetting and microagglutination properties of Plasmodium falciparum‑infected erythrocytes. Proceedings of the 48th Annual Sessions of SLAAS, 1992; pp 1.
Rosetting of Plasmodium falciparum‑infected cells with uninfected red cells enhances microvascular obstruction under flow conditions
Kaul DK, Roth Jr EF, Nagel RL, Howard RJ, and Handunnetti SM. Rosetting of Plasmodium falciparum‑infected cells with uninfected red cells enhances microvascular obstruction under flow conditions. Blood, 1991; 78:812‑819
Expression of CD36 on erythrocytes and its involvement as a Rosetting receptor for Plasmodium falciparum infected erythrocytes
Handunnetti SM, van Schravendijk M‑R, Hasler TH, Barnwell JW, Greenwalt DE, and Howard RJ. Expression of CD36 on erythrocytes and its involvement as a Rosetting receptor for Plasmodium falciparum‑infected erythrocytes.Proceedings of 47thAnnual Sessions of SLAAS, 1991; pp 11.
Characterization of a ~260 kD surface antigen of Plasmodium falciparum infected erythrocytes
Handunnetti SM, van Schravendijk M‑R, Pasloske BL, Kapilananda GMG, Perera KLRL, Mendis KN, and Howard RJ. Characterization of a ~260 kD surface antigen of Plasmodium falciparum ‑ infected erythrocytes. Proceedings of the 47th Annual Sessions of SLAAS, 1991; pp 14.
Surface molecules on Plasmodium falciparum‑infected erythrocytes involved in adherence
Howard RJ, Handunnetti SM, Hasler TH, Gilladoga AD, Aguiar JC, Pasloske BL, Morehead K, Albrecht GR, and van Schravendijk M‑R. Surface molecules on Plasmodium falciparum‑infected erythrocytes involved in adherence. American Journal Tropical Medicine & Hygiene, 1990; 43(2) suppl:15‑29
Rosetting of Plasmodium falciparum malaria: Phenotypic diversity in wild isolates, receptor characterization and ex vivo micro‑circulatory studies
Handunnetti SM, Hasler TH, van Schravendijk M‑R, Aguirar JC, Roth Jr EF, Kaul DK, Nagel RL, and Howard RJ. Rosetting of Plasmodium falciparum malaria: Phenotypic diversity in wild isolates, receptor characterization and ex vivo micro‑circulatory studies. 7th International Congress of Parasitology (ICOPA), Paris 20- 24th August 1990; pp 128
In vitro rosetting, cytoadherence, and microagglutination properties of Plasmodium falciparum‑infected erythrocytes from Gambian and Tanzanian patients
Hasler TH, Handunnetti SM, Aguiar JC, van Schravendijk M‑R, Greenwood BM, Lallinger G, Cegielski P, and Howard RJ. In vitro rosetting, cytoadherence, and microagglutination properties of Plasmodium falciparum‑infected erythrocytes from Gambian and Tanzanian patients. Blood, 1990; 76: 1845‑1852
Genes for Plasmodium falciparum surface antigens cloned by expression in COS cells
Elliott JFE, Albrecht GR, Gilladoga AD, Handunnetti SM, Neequaye J, Lallinger G, Minjas JN, and Howard RJ. Genes for Plasmodium falciparum surface antigens cloned by expression in COS cells. Proceedings National Academy of Science, U. S. A. 1990; 87:6363‑6367
A new cytoadherence property of Plasmodium falciparum‑infected erythrocytes: Rosetting with uninfected erythrocytes
Handunnetti SM, Gilladoga AD, and Howard RJ. A new cytoadherence property of Plasmodium falciparum‑infected erythrocytes: Rosetting with uninfected erythrocytes. In “Cellular and Molecular Biology of Normal and Abnormal erythroid Membranes”. UCLA Symposia, Alan R. Liss Inc., Publishers, New York.1990; 249‑265
Uninfected erythrocytes form rosettes around Plasmodium falciparum infected erythrocytes
Handunnetti SM, David PH, Perera KLRL, and Mendis KN. Uninfected erythrocytes form rosettes around Plasmodium falciparum infected erythrocytes. American Journal Tropical Medicine & Hygiene, 1989; 40:115‑118
Structural and functional alterations of the erythrocyte membrane in malaria
Handunnetti SM, and Howard RJ. Structural and functional alterations of the erythrocyte membrane in malaria. Journal of Cellular Biochemistry (supplement) 1989; 13B: pp 216