Rukshala BAD, De Silva ED, Ranaweera BVLR, Fernando N, Handunnetti SM

Publications in Peer-reviewed indexed Journals
Rukshala BAD, De Silva ED, Ranaweera BVLR, Fernando N, Handunnetti SM
Publication year: 2021

Rukshala BAD, De Silva ED, Ranaweera BVLR, Fernando N, Handunnetti SM. Anti-inflammatory effect of leaves of Vernonia zeylanica in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced rat paw-edema model. Journal of Ethnopharmacology, 2021; 274: 114030; doi.org/10.1016/j.jep.2021.114030

Ion transport modulators differentially modulate inflammatory responses in THP-1-Derived Macrophages

Publications in Peer-reviewed indexed Journals
Mitini-Nkhoma SC, Fernando N, Ishaka GKD, Handunnetti SM, Pathirana SL
Publication year: 2021

Mitini-Nkhoma SC, Fernando N, Ishaka GKD, Handunnetti SM, Pathirana SL.  Ion transport modulators differentially modulate inflammatory responses in THP-1-Derived Macrophages. Journal of Immunology Research, 2021; Volume 2021, Article ID 8832586, 9 pages, https://doi.org/10.1155/2021/8832586

Dynamics of maternally transferred antibodies against measles, mumps and rubella in infants in Sri Lanka

Publications in Peer-reviewed indexed Journals
Muthiah N, Galagoda G, Handunnetti S, Peiris S, Pathirana S
Publication year: 2021

Muthiah N, Galagoda G, Handunnetti S, Peiris S, Pathirana S. Dynamics of maternally transferred antibodies against measles, mumps and rubella in infants in Sri Lanka. International Journal of Infectious Diseases, 2021; 107:129-134

Development of in-house ELISAs as an alternative method for the serodiagnosis of leptospirosis

Publications in Peer-reviewed indexed Journals
Roshan Niloofa, Lilani Karunanayake, H Janaka de Silva, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti
Publication year: 2021

Roshan Niloofa, Lilani Karunanayake, H Janaka de Silva, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti. Development of in-house ELISAs as an alternative method for the serodiagnosis of leptospirosis, International Journal of Infectious Diseases, 2021; 105: 135-140

Vitex negundo L. leaf extract inhibits IL-6 and TNF-α secretion and phagocytosis in human leukocytes

Publications in Peer-reviewed indexed Journals
K.W.J.C. Kariyawasam, P.D.N.N. Sirisena, H.L.C. Nanayakkara, W.D. Ratnasooriya, S.M. Handunnetti
Publication year: 2020

K.W.J.C. Kariyawasam, P.D.N.N. Sirisena, H.L.C. Nanayakkara, W.D. Ratnasooriya, S.M. Handunnetti. Vitex negundo L. leaf extract inhibits IL-6 and TNF-α secretion and phagocytosis in human leukocytes, Journal of Herbal Medicine, 2020, doi:https://doi.org/10.1016/ j.hermed. 2020.100341

Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata, Its Main Constituents, and Possible Mechanism of Action

Publications in Peer-reviewed indexed Journals
Madhuvanthi Chandrakanthan, Shiroma M. Handunnetti, Galbada Sirimal Arachchige Premakumara, and Selvaluxmy Kathirgamanathar
Publication year: 2020

Madhuvanthi Chandrakanthan, Shiroma M. Handunnetti, Galbada Sirimal Arachchige Premakumara, and Selvaluxmy Kathirgamanathar. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata, Its Main Constituents, and Possible Mechanism of Action, Evidence-Based Complementary and Alternative Medicine, 2020, Article ID 2035671, 19 pages https://doi.org/10.1155/2020/2035671

The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension—evidence from the APPROPRIATE trial 2020

Publications in Peer-reviewed indexed Journals
Ranasinghe HN, Fernando N, Handunnetti S, Weeratunga PN, Katulanda P, Rajapakse S, Galappatthy P, Constantine G R
Publication year: 2020

Ranasinghe HN, Fernando N, Handunnetti S, Weeratunga PN, Katulanda P, Rajapakse S, Galappatthy P, Constantine G R. The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension—evidence from the APPROPRIATE trial 2020, BMC Res Notes; 13:228  https://doi.org/10. 1186/s13104-020-05067-5

Seroprevalence of leptospirosis in an endemic mixed urban and semi-urban setting— A community-based study in the district of Colombo, Sri Lanka

Publications in Peer-reviewed indexed Journals
Rajapakse S, Weeratunga PN, Balaji K, Ramchandani KC, de Silva US, Ranasinghe SA, Dinesh Gunarathne, Pasindu P. B. Wijerathne, Narmada Fernando, Shiroma M. Handunnetti, Sumadhya Deepika Fernando.
Publication year: 2020

Rajapakse S, Weeratunga PN, Balaji K, Ramchandani KC, de Silva US, Ranasinghe SA, Dinesh Gunarathne, Pasindu P. B. Wijerathne, Narmada Fernando, Shiroma M. Handunnetti, Sumadhya Deepika Fernando.. Seroprevalence of leptospirosis in an endemic mixed urban and semi-urban setting— A community-based study in the district of Colombo, Sri Lanka. PLoS Neglected Tropical Diseases, 2020, 14(5): e0008309. https://doi.org/10.1371/journal. pntd.0008309

 

Ion transport modulators as antimicobacterial agents

Publications in Peer-reviewed indexed Journals
Steven C Mitini-Nkhoma.  Narmada Fernando, G K D Ishaka, Shiroma M Handunnetti, Sisira L Pathirana
Publication year: 2020

Steven C Mitini-Nkhoma.  Narmada Fernando, G K D Ishaka, Shiroma M Handunnetti, Sisira L Pathirana. Ion transport modulators as antimicobacterial agents. Tuberculosis Research and Treatment. Vol 2020, Article ID 3767915, 7 pages https://doi.org/10.1155/2020/3767915

Investigation of β-Lactamase enzyme inhibitory, anti-bacterial and anti-fungal bio-activities of Dillenia retusa Thumb: An endemic medicinal plant to Sri Lanka

Publications in Peer-reviewed indexed Journals
Melshandi HDS, Samarasekera JKRR, Handunnetti SM, Weerasena OVDSJ, Maharjan R,  Choudhary MI
Publication year: 2020

Melshandi HDS, Samarasekera JKRR, Handunnetti SM, Weerasena OVDSJ, Maharjan R,  Choudhary MI. Investigation of β-Lactamase enzyme inhibitory, anti-bacterial and anti-fungal bio-activities of Dillenia retusa Thumb: An endemic medicinal plant to Sri Lanka. South Asian Research Journal of Natural Products, 2020; 3(4), 1-12. (https://www.Journalsarjnp.com/index.php/ SARJNP/article/view/30112)

Immunomodulatory activity of traditional Sri Lankan concoction of  Coriandrum sativuma L. and Coscinium fenestratum G

Publications in Peer-reviewed indexed Journals
Shashika D Kothalawala, Daniya Edward, Jayamini C Harasgama, Loshini Ranaweera, OVDSJ Weerasena, Roshan Niloofa,  WD Ratnasooriya, GAS Premakumara, Shiroma M. Handunnetti
Publication year: 2020

Shashika D Kothalawala, Daniya Edward, Jayamini C Harasgama, Loshini Ranaweera, OVDSJ Weerasena, Roshan Niloofa,  WD Ratnasooriya, GAS Premakumara, Shiroma M. Handunnetti. Immunomodulatory activity of traditional Sri Lankan concoction of  Coriandrum sativuma L. and Coscinium fenestratum G. Evidence-Based Complementray and Alternatuive Medicine, 2020; Article ID 9715060, 10 pages https://doi.org/10.1155/2020/9715060

High levels of serum Angiopoietin 2 and Angiopoietin 2/1 ratio at critical stage of dengue hemorrhagic fever patients and their association with clinical and biochemical parameters

Publications in Peer-reviewed indexed Journals
Maheshi Mapalagamage, Shiroma M. Handunnetti, Ananda Rajitha Wickremasinghe, Gayani Premawansa, Sharmila Thillainathan, Tharanga Fernando, Karunayokiny Kanapathippillai, Aruna Dharshan De Silva, Sunil Premawansa
Publication year: 2020

Maheshi Mapalagamage, Shiroma M. Handunnetti, Ananda Rajitha Wickremasinghe, Gayani Premawansa, Sharmila Thillainathan, Tharanga Fernando, Karunayokiny Kanapathippillai, Aruna Dharshan De Silva, Sunil Premawansa.  High levels of serum Angiopoietin 2 and Angiopoietin 2/1 ratio at critical stage of dengue hemorrhagic fever patients and their association with clinical and biochemical parameters. Journal of Clinical Microbiology, 2020, 58:e00436-19. https://doi.org/10 .1128/JCM.00436-19

Haemostatic derangement in leptospirosis: a preliminary prospective comparative study

Publications in Peer-reviewed indexed Journals
Rasa Threeswaran, Nipun Lakshitha De Silva, Roopen Arya, Lallindra Gooneratne, Shiroma M Handunnetti, Senaka Rajapakse
Publication year: 2020

Rasa Threeswaran, Nipun Lakshitha De Silva, Roopen Arya, Lallindra Gooneratne, Shiroma M Handunnetti, Senaka Rajapakse. Haemostatic derangement in leptospirosis: a preliminary prospective comparative study. International Journal of Critical Illness and Injury Science, 2020; 10: 28-32

Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study

Publications in Peer-reviewed indexed Journals
Fernando Y, Wickremeshinghe P, De Silva U, Alahakoon M, Anuradha KWDA and Handunnetti S.
Publication year: 2020

Fernando Y, Wickremeshinghe P, De Silva U, Alahakoon M, Anuradha KWDA and Handunnetti S. Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study, Allergy Asthma & Clinical Immunology 2020 16:66 https://doi.org/10.1186/s13223-020-00463-9

Anti-Inflammatory Activity of Pleurotus ostreatus, a Culinary Medicinal Mushroom, in Wistar Rats

Publications in Peer-reviewed indexed Journals
J.A. Banukie N. Jayasuriya, Shiroma M. Handunnetti, Chandanie A. Wanigatunge, Gita H. Fernando, D. Thusitha U. Abeytunga, and T. Sugandhika Suresh
Publication year: 2020

J.A. Banukie N. Jayasuriya, Shiroma M. Handunnetti, Chandanie A. Wanigatunge, Gita H. Fernando, D. Thusitha U. Abeytunga, and T. Sugandhika Suresh. Anti-Inflammatory Activity of Pleurotus ostreatus, a Culinary Medicinal Mushroom, in Wistar Rats. Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 6845383, 9 pages https://doi.org/10.1155/2020/6845383

Risk prediction for severe disease in early dengue infection; the Colombo Dengue Study

Publications in Peer-reviewed indexed Journals
P Chathurani Sigera, Ranmalee Amarasekara, Chaturaka Rodrigo, Senaka Rajapakse, Praveen Weerathunga, Nipun Lakshitha De Silva, ChunHong Huang, Malaya K. Sahoo, Benjamin A. Pinsky, Dylan R. Pillai, Hasitha A. Tissera, Saroj Jayasinghe, Shiroma Handunnetti, Deepika Fernando
Publication year: 2019

P Chathurani Sigera, Ranmalee Amarasekara, Chaturaka Rodrigo, Senaka Rajapakse, Praveen Weerathunga, Nipun Lakshitha De Silva, ChunHong Huang, Malaya K. Sahoo, Benjamin A. Pinsky, Dylan R. Pillai, Hasitha A. Tissera, Saroj Jayasinghe, Shiroma Handunnetti, Deepika Fernando. Risk prediction for severe disease in early dengue infection; the Colombo Dengue Study. BMC Infectious Diseases, 2019, 19:680

Protocol for harvesting adult human hippocampus

Publications in Peer-reviewed indexed Journals
Mathangasinghe Y, Handunnetti SM, Warawitage DH, Dissanayake DN
Publication year: 2019

Mathangasinghe Y, Handunnetti SM, Warawitage DH, Dissanayake DN. Protocol for harvesting adult human hippocampus. Sri Lanka Anatomy Journal. 2019;3(2):99. DOI: http://doi.org/10.4038/ slaj.v3i2.85

Diagnosis of Vespa affinis venom allergy: Use of immunochemical methods and a passive basophil activation test

Publications in Peer-reviewed indexed Journals
Peshala Gunasekara; SM Handunnetti; Sunil Premawansa; Pradeep Kaluarachchi; Chandima Karunathilake; Indra P Ratnayake; RKS Dias; GAS Premakumara; WMDK Dasanayake; Suranjith L Seneviratne; Rajiva de Silva
Publication year: 2019

Peshala Gunasekara; SM Handunnetti; Sunil Premawansa; Pradeep Kaluarachchi; Chandima Karunathilake; Indra P Ratnayake; RKS Dias; GAS Premakumara; WMDK Dasanayake; Suranjith L Seneviratne; Rajiva de Silva. Diagnosis of Vespa affinis venom allergy: Use of immunochemical methods and a passive basophil activation test. Allergy, Asthma & Clinical Immunology, 2019; 15:80 https://doi.org/10.1186/s13223-019-0394-6

Utility of pf/pan RDT for diagnosis in the phase of prevention of re-establishment of malaria in Sri Lanka

Publications in Peer-reviewed indexed Journals
Kumudunayana Gunasekera, Risintha Premaratne, Jagathpriya Weerasena, Sunil Premawansa, Shiroma Handunnetti, Deepika Fernando
Publication year: 2018

Kumudunayana Gunasekera, Risintha Premaratne, Jagathpriya Weerasena, Sunil Premawansa, Shiroma Handunnetti, Deepika Fernando. Utility of pf/pan RDT for diagnosis in the phase of prevention of re-establishment of malaria in Sri Lanka. Pathogens and Global Health, 2018. Oct;112(7):360-367. doi: 10.1080/20477724.2018.1536855. Epub 2018 Oct 24

The effect of antimicrobial agents on inflammatory cytokines in acute leptospirosis

Publications in Peer-reviewed indexed Journals
Narmada Fernando, Rajiva de Silva, Shiroma M Handunnetti, Lilani Karunanayake, Nipun Lakshitha De Silva, H Janaka de Silva, Senaka Rajapakse, Sunil Premawansa
Publication year: 2018

Narmada Fernando, Rajiva de Silva, Shiroma M Handunnetti, Lilani Karunanayake, Nipun Lakshitha De Silva, H Janaka de Silva, Senaka Rajapakse, Sunil Premawansa. The effect of antimicrobial agents on inflammatory cytokines in acute leptospirosis. Antimicrobial Agents and Chemotherapy. May 2018; 62(5) e02312-17. r62:e02312-17.https://doi .org/10.1128/ AAC.02312-17

Preliminary study on Chronic granulomatous disease in Sri Lanka

Publications in Peer-reviewed indexed Journals
Fernando SJA, Faiz NM, Handunnetti SM, De Silva AD, Dasanayake WMDK, Wickremasinghe GD, Karunatilake RMCH, De Silva R
Publication year: 2018

Fernando SJA, Faiz NM, Handunnetti SM, De Silva AD, Dasanayake WMDK, Wickremasinghe GD, Karunatilake RMCH, De Silva R. Preliminary study on Chronic granulomatous disease in Sri Lanka. Allergy Asthma & Clinical Immunology. 2018; 14: 37. doi:  10.1186/s13223-018-0264-7

Is total serum nitrite and nitrate (NOx) level in dengue patients a potential prognostic marker of dengue haemorrhagic fever?

Publications in Peer-reviewed indexed Journals
Maheshi Sasika Mapalagamage, Shiroma Mangalika Handunnetti, Gayani Premawansa, Sharmila Thillainathan, Geekiyanage Tharanga Geethapriya Fernando, Karunayokiny Kanapathippillai, Rajitha Wickremeshinghe, Aruna Dharshan de Silva, Sunil Premawansa
Publication year: 2018

Maheshi Sasika Mapalagamage, Shiroma Mangalika Handunnetti, Gayani Premawansa, Sharmila Thillainathan, Geekiyanage Tharanga Geethapriya Fernando, Karunayokiny Kanapathippillai, Rajitha Wickremeshinghe, Aruna Dharshan de Silva, Sunil Premawansa. Is total serum nitrite and nitrate (NOx) level in dengue patients a potential prognostic marker of dengue haemorrhagic fever? Disease Markers, 2018; Article ID: 5328681, doi.org/10.1155/2018/5328681

In vitro pro-inflammatory enzyme inhibition and anti-oxidant potential of selected Sri Lankan medicinal plants

Publications in Peer-reviewed indexed Journals
Perera, HDSM, Samarasekara R, Handunnetti S, Weerasena OVDS, Weeratunga HD, Jabeen A, Chaudhary MI
Publication year: 2018

Perera, HDSM, Samarasekara R, Handunnetti S, Weerasena OVDS, Weeratunga HD, Jabeen A, Chaudhary MI. In vitro pro-inflammatory enzyme inhibition and anti-oxidant potential of selected Sri Lankan medicinal plants. BMC Complementary and Alternative Medicine. 2018; 18: 271

Comparison of antioxidant properties of Cyathula prostrata Linn and Achyranthes aspera Linn grown in Sri Lanka

Publications in Peer-reviewed indexed Journals
Dissanayake DPA, Sivaganesh S, Tissera MHA, Handunnetti SM, Arawwawala LDAM
Publication year: 2018

Dissanayake DPA, Sivaganesh S, Tissera MHA, Handunnetti SM, Arawwawala LDAM. Comparison of antioxidant properties of Cyathula prostrata Linn and Achyranthes aspera Linn grown in Sri Lanka, Research and Review Insights, 2018; 2(3):1-3; ISSN: 2515-2637; doi: 10.15761/RRI.1000138.

 

A bioactive resveratrol trimer from the stem bark of Sri Lankan endemic plant Vateria copallifera

Publications in Peer-reviewed indexed Journals
Samaradivakara SP, Samarasekera R, Handunnetti SM, Weerasena OVDSJ, Al-Hamashi AA, Slama JT, Taylor WR, Alhadidi Q, Shah ZA, Perera L, Tillekeratne LMV
Publication year: 2018

Samaradivakara SP, Samarasekera R, Handunnetti SM, Weerasena OVDSJ, Al-Hamashi AASlama JTTaylor WRAlhadidi QShah ZAPerera LTillekeratne LMV. A bioactive resveratrol trimer from the stem bark of Sri Lankan endemic plant Vateria copallifera. Journal of Natural Products. 2018 Jul 24. doi: 10.1021/acs.jnatprod.7b00892. [Epub ahead of print]

Phytochemical profile and in vitro anti-inflammatory activity of aqueous leaf extract of Sri Lankan variety of Psidium guajava L

Publications in Peer-reviewed indexed Journals
Kariyawasam. K. W. J. C., Pathirana. R. N., Ratnasooriya W. D., S. Handunnetti and Abeysekera W. P. K. M
Publication year: 2017

Kariyawasam. K. W. J. C., Pathirana. R. N., Ratnasooriya W. D., S. Handunnetti and Abeysekera W. P. K. M. Phytochemical profile and in vitro anti-inflammatory activity of aqueous leaf extract of Sri Lankan variety of Psidium guajava L. Journal of Pharmacognosy and Phytochemistry, 2017; 6(4). 22-26

IgE cross-reactivity of phospholipase A2 and hyaluronidase of Apis dorsata (Giant Asian honeybee) and Apis mellifera (Western honeybee) venom: Possible use of A. mellifera venom for diagnosis and immunotherapy of patients allergic to A. dorsata venom

Publications in Peer-reviewed indexed Journals
Peshala Gunasekara, Shiroma Handunnetti, Sunil Premawansa, Elapatha Witharana, Dhanushka Dasanayake, Padmini Ratnayake, Suranjith Seneviratne, Sriyani Dias, Sirimal Premakumara, Rajiva de Silva
Publication year: 2017

Peshala Gunasekara, Shiroma Handunnetti, Sunil Premawansa, Elapatha Witharana, Dhanushka Dasanayake, Padmini Ratnayake, Suranjith Seneviratne, Sriyani Dias, Sirimal Premakumara, Rajiva de Silva. IgE cross-reactivity of phospholipase A2 and hyaluronidase of Apis dorsata (Giant Asian honeybee) and Apis mellifera (Western honeybee) venom: Possible use of A. mellifera venom for diagnosis and immunotherapy of patients allergic to A. dorsata venom. TOXICON, 2017; 137:27-35

Bioactivities of n-hexane fraction of Vateria copallifera and GC–MS anlysis of its phytoconstituents

Publications in Peer-reviewed indexed Journals
Saroopa P Samaradivakara, Radhika Samarasekera, Viranga Tilekeratne, Shiroma M Handunnetti, Jagathpriya Weerasena, William R Taylor, Qasim Alhadidi, Zahoor A Shah.
Publication year: 2017

Saroopa P Samaradivakara, Radhika Samarasekera, Viranga Tilekeratne, Shiroma M Handunnetti, Jagathpriya Weerasena, William R Taylor, Qasim Alhadidi, Zahoor A Shah. Bioactivities of n-hexane fraction of Vateria copallifera and GC–MS anlysis of its phytoconstituents. Industrial Crops and Products, 2017; 97:87-92

Synthesis   and   characterization   of   novel   Rhenium (I)   complexes   towards potential biological imaging applications

Publications in Peer-reviewed indexed Journals
Kokila Ranasinghe, Shiroma Handunetti, Inoka C Perera, Theshini Perera
Publication year: 2016

Kokila Ranasinghe, Shiroma Handunetti, Inoka C Perera, Theshini Perera. Synthesis   and   characterization   of   novel   Rhenium (I)   complexes   towards potential biological imaging applications. Chemistry Central Journal. 2016; 10(1). DOI: 10.1186/s13065-016-0218-4

Role of Human Neutrophils in Inflammation and it’s Modulation by Ixora coccinea

Publications in Peer-reviewed indexed Journals
Rachitha Wickremesinghe, Shiroma Handunnetti
Publication year: 2016

Rachitha Wickremesinghe, Shiroma Handunnetti. Role of Human Neutrophils in Inflammation and it’s Modulation by Ixora coccinea. Research and Reviews: A Journal of Immunology, 2016; 6(1):32-48