Professor Shiroma M Handunnetti
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
Filter by type:
Rukshala BAD, De Silva ED, Ranaweera BVLR, Fernando N, Handunnetti SM
Rukshala BAD, De Silva ED, Ranaweera BVLR, Fernando N, Handunnetti SM. Anti-inflammatory effect of leaves of Vernonia zeylanica in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced rat paw-edema model. Journal of Ethnopharmacology, 2021; 274: 114030; doi.org/10.1016/j.jep.2021.114030
Ion transport modulators differentially modulate inflammatory responses in THP-1-Derived Macrophages
Mitini-Nkhoma SC, Fernando N, Ishaka GKD, Handunnetti SM, Pathirana SL. Ion transport modulators differentially modulate inflammatory responses in THP-1-Derived Macrophages. Journal of Immunology Research, 2021; Volume 2021, Article ID 8832586, 9 pages, https://doi.org/10.1155/2021/8832586
Dynamics of maternally transferred antibodies against measles, mumps and rubella in infants in Sri Lanka
Muthiah N, Galagoda G, Handunnetti S, Peiris S, Pathirana S. Dynamics of maternally transferred antibodies against measles, mumps and rubella in infants in Sri Lanka. International Journal of Infectious Diseases, 2021; 107:129-134
Development of in-house ELISAs as an alternative method for the serodiagnosis of leptospirosis
Roshan Niloofa, Lilani Karunanayake, H Janaka de Silva, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti. Development of in-house ELISAs as an alternative method for the serodiagnosis of leptospirosis, International Journal of Infectious Diseases, 2021; 105: 135-140
Vitex negundo L. leaf extract inhibits IL-6 and TNF-α secretion and phagocytosis in human leukocytes
K.W.J.C. Kariyawasam, P.D.N.N. Sirisena, H.L.C. Nanayakkara, W.D. Ratnasooriya, S.M. Handunnetti. Vitex negundo L. leaf extract inhibits IL-6 and TNF-α secretion and phagocytosis in human leukocytes, Journal of Herbal Medicine, 2020, doi:https://doi.org/10.1016/ j.hermed. 2020.100341
Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata, Its Main Constituents, and Possible Mechanism of Action
Madhuvanthi Chandrakanthan, Shiroma M. Handunnetti, Galbada Sirimal Arachchige Premakumara, and Selvaluxmy Kathirgamanathar. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata, Its Main Constituents, and Possible Mechanism of Action, Evidence-Based Complementary and Alternative Medicine, 2020, Article ID 2035671, 19 pages https://doi.org/10.1155/2020/2035671
The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension—evidence from the APPROPRIATE trial 2020
Ranasinghe HN, Fernando N, Handunnetti S, Weeratunga PN, Katulanda P, Rajapakse S, Galappatthy P, Constantine G R. The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension—evidence from the APPROPRIATE trial 2020, BMC Res Notes; 13:228 https://doi.org/10. 1186/s13104-020-05067-5
Seroprevalence of leptospirosis in an endemic mixed urban and semi-urban setting— A community-based study in the district of Colombo, Sri Lanka
Rajapakse S, Weeratunga PN, Balaji K, Ramchandani KC, de Silva US, Ranasinghe SA, Dinesh Gunarathne, Pasindu P. B. Wijerathne, Narmada Fernando, Shiroma M. Handunnetti, Sumadhya Deepika Fernando.. Seroprevalence of leptospirosis in an endemic mixed urban and semi-urban setting— A community-based study in the district of Colombo, Sri Lanka. PLoS Neglected Tropical Diseases, 2020, 14(5): e0008309. https://doi.org/10.1371/journal. pntd.0008309
Ion transport modulators as antimicobacterial agents
Steven C Mitini-Nkhoma. Narmada Fernando, G K D Ishaka, Shiroma M Handunnetti, Sisira L Pathirana. Ion transport modulators as antimicobacterial agents. Tuberculosis Research and Treatment. Vol 2020, Article ID 3767915, 7 pages https://doi.org/10.1155/2020/3767915
Investigation of β-Lactamase enzyme inhibitory, anti-bacterial and anti-fungal bio-activities of Dillenia retusa Thumb: An endemic medicinal plant to Sri Lanka
Melshandi HDS, Samarasekera JKRR, Handunnetti SM, Weerasena OVDSJ, Maharjan R, Choudhary MI. Investigation of β-Lactamase enzyme inhibitory, anti-bacterial and anti-fungal bio-activities of Dillenia retusa Thumb: An endemic medicinal plant to Sri Lanka. South Asian Research Journal of Natural Products, 2020; 3(4), 1-12. (https://www.Journalsarjnp.com/index.php/ SARJNP/article/view/30112)
Immunomodulatory activity of traditional Sri Lankan concoction of Coriandrum sativuma L. and Coscinium fenestratum G
Shashika D Kothalawala, Daniya Edward, Jayamini C Harasgama, Loshini Ranaweera, OVDSJ Weerasena, Roshan Niloofa, WD Ratnasooriya, GAS Premakumara, Shiroma M. Handunnetti. Immunomodulatory activity of traditional Sri Lankan concoction of Coriandrum sativuma L. and Coscinium fenestratum G. Evidence-Based Complementray and Alternatuive Medicine, 2020; Article ID 9715060, 10 pages https://doi.org/10.1155/2020/9715060
High levels of serum Angiopoietin 2 and Angiopoietin 2/1 ratio at critical stage of dengue hemorrhagic fever patients and their association with clinical and biochemical parameters
Maheshi Mapalagamage, Shiroma M. Handunnetti, Ananda Rajitha Wickremasinghe, Gayani Premawansa, Sharmila Thillainathan, Tharanga Fernando, Karunayokiny Kanapathippillai, Aruna Dharshan De Silva, Sunil Premawansa. High levels of serum Angiopoietin 2 and Angiopoietin 2/1 ratio at critical stage of dengue hemorrhagic fever patients and their association with clinical and biochemical parameters. Journal of Clinical Microbiology, 2020, 58:e00436-19. https://doi.org/10 .1128/JCM.00436-19
Haemostatic derangement in leptospirosis: a preliminary prospective comparative study
Rasa Threeswaran, Nipun Lakshitha De Silva, Roopen Arya, Lallindra Gooneratne, Shiroma M Handunnetti, Senaka Rajapakse. Haemostatic derangement in leptospirosis: a preliminary prospective comparative study. International Journal of Critical Illness and Injury Science, 2020; 10: 28-32
Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study
Fernando Y, Wickremeshinghe P, De Silva U, Alahakoon M, Anuradha KWDA and Handunnetti S. Differences in serum markers of oxidative stress in well controlled and poorly controlled asthma in Sri Lankan children: a pilot study, Allergy Asthma & Clinical Immunology 2020 16:66 https://doi.org/10.1186/s13223-020-00463-9
Anti-Inflammatory Activity of Pleurotus ostreatus, a Culinary Medicinal Mushroom, in Wistar Rats
J.A. Banukie N. Jayasuriya, Shiroma M. Handunnetti, Chandanie A. Wanigatunge, Gita H. Fernando, D. Thusitha U. Abeytunga, and T. Sugandhika Suresh. Anti-Inflammatory Activity of Pleurotus ostreatus, a Culinary Medicinal Mushroom, in Wistar Rats. Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 6845383, 9 pages https://doi.org/10.1155/2020/6845383
Study on identification of lipopolysaccharide types in Burkholderia pseudomallei strains isolated from patients in Sri Lanka. (PP06)
NM Kiyas, E Corea, N Fernando, SM Handunnetti. Study on identification of lipopolysaccharide types in Burkholderia pseudomallei strains isolated from patients in Sri Lanka. (PP06). Proceedings of the 9th Biennial Scientific Sessions, Allergy and Immunology Society of Sri Lanka, pp 32
Risk prediction for severe disease in early dengue infection; the Colombo Dengue Study
P Chathurani Sigera, Ranmalee Amarasekara, Chaturaka Rodrigo, Senaka Rajapakse, Praveen Weerathunga, Nipun Lakshitha De Silva, ChunHong Huang, Malaya K. Sahoo, Benjamin A. Pinsky, Dylan R. Pillai, Hasitha A. Tissera, Saroj Jayasinghe, Shiroma Handunnetti, Deepika Fernando. Risk prediction for severe disease in early dengue infection; the Colombo Dengue Study. BMC Infectious Diseases, 2019, 19:680
Risk factors and school absenteeism in children with asthma from an urban afrea of Sri Lanka
Fernando Y, Anuradha KWDA, De Silva U, Alahakoon M, Handunnetti S, Wickremeshinghe P. Risk factors and school absenteeism in children with asthma from an urban afrea of Sri Lanka. Proceedings of the 133rd Anniversary of Sri Lanka Medical Association, 2019
Protocol for harvesting adult human hippocampus
Mathangasinghe Y, Handunnetti SM, Warawitage DH, Dissanayake DN. Protocol for harvesting adult human hippocampus. Sri Lanka Anatomy Journal. 2019;3(2):99. DOI: http://doi.org/10.4038/ slaj.v3i2.85
Preliminary study on bacterial load of Leptospira among severe and mild leptospirosis patients (OP13)
Chandrapathma WPNS, Weerasena OVDSJ, Rajapakse S, Premawansa S, Karunanayake L, Handunnetti SM. Preliminary study on bacterial load of Leptospira among severe and mild leptospirosis patients (OP13). Proceeding of the 11th Annual Scientific Sessions of Institute of Biochemistry, Molecular Biology & Biotechnology (IBMBB), University of Colombo. 12th July 2019, pp:27
omparison of IgG and IgM responses in rats immunized with two types of antigen preparations of Leptospira biflexa serovar Patoc (OP08)
Gangani PD, Ishaka GKD, Fernando N, Karunanayake L, Rajapakse S, S, Premawansa S, Handunnetti SM. Comparison of IgG and IgM responses in rats immunized with two types of antigen preparations of Leptospira biflexa serovar Patoc (OP08). Proceeding of the 11th Annual Scientific Sessions of Institute of Biochemistry, Molecular Biology & Biotechnology (IBMBB), University of Colombo. 12th July 2019, pp:22
In vitro study on the involvements of Angiopoietin-1 and Angiopoietin-2 in severe dengue patient sera leading to endothelial dysfunction and fluid leakage (OP09)
Dasanayaka HMNN, Mapalagamage M, Premawansa G, Handunnetti SM, Premawansa S. In vitro study on the involvements of Angiopoietin-1 and Angiopoietin-2 in severe dengue patient sera leading to endothelial dysfunction and fluid leakage (OP09). Proceeding of the 11th Annual Scientific Sessions of Institute of Biochemistry, Molecular Biology & Biotechnology (IBMBB), University of Colombo. 12th July 2019, pp:23
In vitro study of IgE independent basophil degranulation due to selected food items (OP07)
Wijerathna DMCK, Handunnetti SM, Fernando N, Premawansa S. In vitro study of IgE independent basophil degranulation due to selected food items (OP07). Proceeding of the 11th Annual Scientific Sessions of Institute of Biochemistry, Molecular Biology & Biotechnology (IBMBB), University of Colombo. 12th July 2019, pp:21
In vitro effects of methanol-dichloromethane extract of Vernonia zeylanica and its solvent fractions on human, matured KU 812-derived basophils (OP12)
Ezechukwu HC, Rukshala BAD, Dilini I, Fernando TRGN, Handunnetti SM. In vitro effects of methanol-dichloromethane extract of Vernonia zeylanica and its solvent fractions on human, matured KU 812-derived basophils (OP12). Proceeding of the 11th Annual Scientific Sessions of Institute of Biochemistry, Molecular Biology & Biotechnology (IBMBB), University of Colombo. 12th July 2019, pp:26
Identification of immunogens of L. biflexa serovar Patoc. (OP3)
Gangani PD, Anuradha WGK, Fernando N, Tammitiyagodage MG, Karunanayake L, Rajapakse S, Premawansa S, Handunnetti SM. Identification of immunogens of L. biflexa serovar Patoc. (OP3). Proceedings of the 9th Biennial Scientific Sessions, Allergy and Immunology Society of Sri Lanka, pp 17
Identification of allergens in coconut milk and oil with 18 subjects in Sri Lanka: A preliminary study. (OP10)
Iddagoda IDJH, Gunasekara DLPE, Handunnetti SM, Jeewandara JMC, Karunathilaka C, Malavige GN, de Silva NR, Dasanayake WMDK. Identification of allergens in coconut milk and oil with 18 subjects in Sri Lanka: A preliminary study. (OP10). Proceedings of the 9th Biennial Scientific Sessions, Allergy and Immunology Society of Sri Lanka, pp 24
Expression of co-stimulatory molecules involved in T-cell dependent B-cell activation in rats orally treated with a polyherbal formulation (OP06)
Ranaweera BVLR, Abeysekera AM, Weerasena OVDSJ, Handunnetti SM. Expression of co-stimulatory molecules involved in T-cell dependent B-cell activation in rats orally treated with a polyherbal formulation (OP06). Proceeding of the 11th Annual Scientific Sessions of Institute of Biochemistry, Molecular Biology & Biotechnology (IBMBB), University of Colombo. 12th July 2019, pp:20
Effects of ion pump and ion channel modulators on activation and function THP-1 derived macrophages (OP11)
Mitini-Nkhoma SC, Pathirana PPSL, Fernando TRGN, Handunnetti SM, Ishaka D. Effects of ion pump and ion channel modulators on activation and function THP-1 derived macrophages (OP11). Proceeding of the 11th Annual Scientific Sessions of Institute of Biochemistry, Molecular Biology & Biotechnology (IBMBB), University of Colombo. 12th July 2019, pp:25
Effect of pharmacological compounds and plant extracts on dengue virus induced rat basophil degranulation. (OP9)
Wijegunarathna KVC, Fernando N, Hadunnetti SM, Premawansa S. Effect of pharmacological compounds and plant extracts on dengue virus induced rat basophil degranulation. (OP9). Proceedings of the 9th Biennial Scientific Sessions, Allergy and Immunology Society of Sri Lanka, pp 23
Differences in serum markers of oxidative stress in well controlled and poorly controlled asthmatic children in Sri Lanka
Fernando Y, Wickremeshinghe P, Anuradha KWDA, De Silva U, Alahakoon M, and Handunnetti S. Differences in serum markers of oxidative stress in well controlled and poorly controlled asthmatic children in Sri Lanka. Proceedings of the 133rd Anniversary of Sri Lanka Medical Association, 2019