Professor Shiroma M Handunnetti
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
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Immunity induced by live malarial sporozoites under chloroquine treatment is strain specific
Wijayalath AWWK, Cheeseman S, Rajakaruna J, Weerasinghe S, Kapliananda GMG, Gamage K, Perera K, Handunnetti SM, Carter Rand Pathirana PPSL. Immunity induced by live malarial sporozoites under chloroquine treatment is strain specific. Proceedings of the Research Symposium/Faculty of Medicine, 2010, pp 94
Genetic complexity of Plasmodium vivax infections in Sri Lanka reflected at the Merozoite Surface Protein-3α locus
Wickramarachchi T, Premaratne PH, Dias S, Handunnetti SM and Udagama-Randeniya PV. Genetic complexity of Plasmodium vivax infections in Sri Lanka reflected at the Merozoite Surface Protein-3α locus Annals of Tropical Medicine and Parasitology, 2010; 104:95-108
Cytoadherence and its association with clinical disease in Plasmodium falciparum infections in Sri Lanka
Pathirana PPSL, Ekanayake K, Howard RJ, Mendis KN, and Handunnetti SM. Cytoadherence and its association with clinical disease in Plasmodium falciparum infections in Sri Lanka.The Journal of National Science Foundation, 2010; 38:233-240
Anti-inflammatory activity of Trichosanthes cucumerina Linn.In rats
Arawwawala M, Thabrew I, Arambawela L and Handunnetti SM.Anti-inflammatory activity of Trichosanthes cucumerina Linn.In rats.Journal of Ethnopharmacology, 2010; 131:538-543
Strain-specific protective immunity to pre-erythrocytic stages of malaria parasite, Plasmodium cynomolgi
Wijayalath AWWK, Cheeseman S, Rajakaruna J, Weerasinghe S, Kapliananda GMG, Gamage K, Perera K, Handunnetti SM, Carter R and Pathirana PPSL. Strain-specific protective immunity to pre-erythrocytic stages of malaria parasite, Plasmodium cynomolgi. Proceedings of the 4th Biennial Sessions of the AISSL, 10th July, 2009; pp 17
Spleen modulation of cytoadherence properties of Plasmodium falciparum
Munasighe RA, Ileperuma M, Kapilananda GM, Premawansa G, Handunnetti SM and Premawansa S. Spleen modulation of cytoadherence properties of Plasmodium falciparum.Scandinavian Journal of Infectious Diseases, 2009; 41:538-539
Inhibition of nitric oxide production by Anisomeles indica, Caesalpinia bonduc and Toddalia asiatica extracts
Nanayakkara HLC, Kariyawasam KWJC, Kumara RR, De Silva ED, Ratnasooriya WD and Handunnetti SM. Inhibition of nitric oxide production by Anisomeles indica, Caesalpinia bonduc and Toddalia asiatica extracts. Proceedings of the International Conference on Frontiers in Molecular Life Sciences, IBMBB, University of Colombo,16th -18th September, 2009; pp 38
In vitro anti-inflammatory activity of Vitex negundo
Kariyawasam KWJC, Nanayakkara HLC, Kumara RR, De Silva ED, Ratnasooriya WD andHandunnetti SM. In vitro anti-inflammatory activity of Vitex negundo. Proceedings of the International Conference on Frontiers in Molecular Life Sciences, IBMBB, University of Colombo, 16-18th Sep, 2009; pp 37
Effect of aqueous leaf extracts of Vitex negundo on nitric oxide production and secretion of TNF-α by human leukocytes
Kariyawasam KWJC, Nanayakkara HLC, Kumara RR, De Silva ED, Ratnasooriya WD and Handunnetti SM. Effect of aqueous leaf extracts of Vitex negundo on nitric oxide production and secretion of TNF-α by human leukocytes. Proceedings of the 4th Biennial Sessions of the AISSL, 10th July, 2009; pp 20
Effect of aqueous extracts of Anisomeles indica, Caesalpinia bonduc and Toddalia asiatica on the secretion of pro-inflammatory cytokines by human mononuclear cells
Nanayakkara HLC, Kariyawasam KWJC, Kumara RR, De Silva ED, Ratnasooriya WD and Handunnetti SM. Effect of aqueous extracts of Anisomeles indica, Caesalpinia bonduc and Toddalia asiatica on the secretion of pro-inflammatory cytokines by human mononuclear cells. Proceedings of the 4th Biennial Sessions of the AISSL, 10th July, 2009; pp 19.
Anti-inflammatory activity of methanolic leaf extract of Ixora coccinea
Handunnetti SM, Kumara RR, Deraniyagala SA and Ratnasooriya WD. Anti-inflammatory activity of methanolic leaf extract of Ixora coccinea. Pharmacognosy Research, 2009; 1:80-90
In vitro Anti-Inflammatory activity of aqueous leaf extract of Vitex negundo
De Fonseka WAIRS, Kariyawasam KWJC, Kumara RR, Attanayake DPSTG, De Silva ED, Ratnasooriya WD and Handunnetti SM. In vitro Anti-Inflammatory activity of aqueous leaf extract of Vitex negundo. Agricultural Research Symposium, Wayamba University, 2008; 8:149-153
Evidence for strain-specific protective immunity against blood-stage parasites of Plasmodium cynomolgi in toque monkey
Wijayalath W, Cheesman S, Rajakaruna J, Handunnetti S, Carter R and Pathirana S. Evidence for strain-specific protective immunity against blood-stage parasites of Plasmodium cynomolgi in toque monkey. Parasite Immunology, 2008; 30: 630-636
Effect of aqueous seed extracts of Caesalpinia bonduc on nitric oxide production by rat peritoneal cells in vitro
Sangeetha MD, Nanyakkara HLC, Kumara RR, Attanayake DPSTG, De Silva ED, Ratnasooriya WD and Handunnetti SM. Effect of aqueous seed extracts of Caesalpinia bonduc on nitric oxide production by rat peritoneal cells in vitro. Agricultural Research Symposium, Wayamba University, 2008; 8:165-170
Anti-inflammatory activity of rhizome of Alpinia calcarata
Kalaiarashi K, Kumara RR, Ratnasooriya WD and Handunnetti SM. Anti-inflammatory activity of rhizome of Alpinia calcarata. Proceedings of the 3rd Annual Scientific Sessions of the IBMBB, University of Colombo, 25th April 2008; pp 33
Anti inflammatory activity of leafs of Ixora coccinea: Use of in vitro and in vivo assays for activity-directed fractionation
Kumara RR, Nanayakkara AA, Deraniyagala SA, Ratnasooriya WD and Handunnetti SM. Anti inflammatory activity of leafs of Ixora coccinea: Use of in vitro and in vivo assays for activity-directed fractionation. Proceedings of the 3rd Annual Scientific Sessions of the IBMBB, University of Colombo, 25th April 2008; pp 22
A preliminary study on detection of micrometastasis of breast cancer by immunohistochemical identification of K-19 antigen in axillary lymph nodes
Wittachchi RS, Weerasinghe A, Angunawela P and Handunnetti SM. A preliminary study on detection of micrometastasis of breast cancer by immunohistochemical identification of K-19 antigen in axillary lymph nodes. Proceedings of the 3rd Annual Scientific Sessions of the IBMBB, University of Colombo, 25th April 2008; pp 27
Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites
Tanabe K, Escalante A, Sakihama N, Honda M, Arisue N, Horii T, Culleton R, Hayakawa T, Hashimoto Tetsuo, Longacre S, Pathirana S, Handunnetti S, Kishino H. Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites. Molecular Biochemical Parasitology, 2007; 156:74-79
Patterns of anti-PvRII IgG and IgG isotypes to Plasmodium vivax Duffy Binding Protein in Sri Lanka
Premaratne PH, Dias KVGS, Handunnetti SM, Yazdani S, Chitins C and Udagama-Randeniya PV. Patterns of anti-PvRII IgG and IgG isotypes to Plasmodium vivax Duffy Binding Protein in Sri Lanka (Abstract 018/A). Proceedings of the 63rdAnnual Sessions of the SLAAS, December 2007; pp 17-18
Natural antibody response to Plasmodium vivax merozoite surface proteins-1 and -4 in Sri Lanka
Dissanayake MU, Dias KVGS, Premaratne PH, Wickramarachchi WTA, Handunnetti SM, Longacre S and Udagama-Randeniya PV. Natural antibody response to Plasmodium vivax merozoite surface proteins-1 and -4 in Sri Lanka (Abstract 13). Proceedings of the 2nd Annual Scientific Sessions of the IBMBB, University of Colombo, 27th April 2007; 18
Inhibition of rat peritoneal phagocytic cell function by aqueous leaf extract of Ixora coccinea
De Silva SSP, Kumara RR, Nanayakkara AA, Deraniyagala SA, Ratnasooriya WD, Handunnetti SM. Inhibition of rat peritoneal phagocytic cell function by aqueous leaf extract of Ixora coccinea. Proceedings of the 2nd Annual Scientific Sessions of the IBMBB, University of Colombo, 27th April 2007; pp 21
Immunoepidemiology of PvRII, a putative vaccine candidate representing Plasmodium vivax Duffy Binding Protein, in Sri Lanka
Premaratne PH, Dias KVGS, Handunnetti SM, Yazdani S, Chitins C and Udagama-Randeniya PV. Immunoepidemiology of PvRII, a putative vaccine candidate representing Plasmodium vivax Duffy Binding Protein, in Sri Lanka. Proceedings of the 56th of the Annual Meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, USA, November 2007, pp 55
Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population
Munasinghe-Gunasekera A, Wickramarachchi WTA, Ganguli I, Perera KLRL, Premaratne H, Handunnetti SM, Udagama-Randeniya PV and Wirth DF. Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population. Molecular Biology & Evolution, 2007; 24:939-942
Comparison of naturally acquired antibody responses against the C-terminal products of Plasmodium vivax merozoite surface protein-1 under low transmission and unstable malaria conditions in Sri Lanka
Wickramarachchi WTA, Illeperuma RJ, Perera KLRL, Bandara S, Longacre S, Handunnetti SM and Udagama-Randeniya PV. Comparison of naturally acquired antibody responses against the C-terminal products of Plasmodium vivax merozoite surface protein-1 under low transmission and unstable malaria conditions in Sri Lanka. International Journal of Parasitology, 2007; 37: 199-208
Anti-inflammatory activity of methanol leaf extract of Ixora coccinea in rats
Kumara RR, Nanayakkara AA, Deraniyagala SA and Ratnasooriya WD and Handunnetti SM. Anti-inflammatory activity of methanol leaf extract of Ixora coccinea in rats (Abstract 7). Proceedings of 2nd Annual Scientific Sessions of the IBMBB, University of Colombo, 27th April 2007; 12
Studies on strain-specific protective immunity in malaria using Plasmodium cynomolgi /toque monkey (Macaca sinica) model
Wijayalath AWWK, Cheeseman S, Rajakaruna J, Gamage K, Perera K, Perera KLRL, Carter R, Handunnetti SM and Pathirana PPSL. Studies on strain-specific protective immunity in malaria using Plasmodium cynomolgi /toque monkey (Macaca sinica) model. Proceedings of the 3rd Annual Sessions of the AISSL, 17th November, 2006;B1, pp 24
Specificity of the antibody response to conformational and linear epitopes of Plasmodium vivax Duffy binding protein in Sri Lanka
Premaratne PH, Dias KVGS, Wickramarachchi WTA, Perera KLRL, Bandara S, Chitnis C, Yasdani S, Handunnetti SM and Udagama-Randeniya PV. Specificity of the antibody response to conformational and linear epitopes of Plasmodium vivax Duffy binding protein in Sri Lanka. Proceedings of the 3rd Annual Sessions of the AISSL 17th November, 2006; B2, pp 25-26
Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka
Wickramarachchi T, Premaratne PH, Perera KLRL, Bandara S, Kocken CHM, Thomas AW, HandunnettiSM and Udagama-Randeniya PV. Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka. Infection & Immunity, 2006; 74:798-801
Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite
Merino EF, Fernandez-Becerra C, Alan C, Durham M, Ferreira JE, Tumilsci VF, d’Arc-Neves J, da Silva-Nunes M, Ferreira MU, Wickramarachchi TA, Udagama-Randeniya PV, Handunnetti SM and del Portillo HA. Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite. Molecular Biochemical Parasitology, 2006; 149: 10-16
Investigations on anti-inflammatory potential and chemical constituents of Ixora coccinea, Vitex negundo and Alpinia calcarata
Kumara RR, Handunnetti SM, Deraniyagala SA and Ratnasooriya WD. Investigations on anti-inflammatory potential and chemical constituents of Ixora coccinea, Vitex negundo and Alpinia calcarata. Proceedings of the 1st Annual Scientific Sessions of the Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, 28th April 2006; pp 15