Professor Shiroma M Handunnetti
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
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Alpinia calcarata rhizome extracts: Prospective inhibitors of inflammatory mediators
M Chandhrakanthan, S Kathirgamanathar, SM Handunnetti, GAS Premakumara. Alpinia calcarata rhizome extracts: Prospective inhibitors of inflammatory mediators. Proceedings of 8th International Research Conference- Kotelawala Defense University (2015)
Adjuvant effect of combined hot water extract of Coriandrum sativum L. and Coscinium fenestratum on rat antibody response against Leptospira antigens
Siriwardene AR, Handunnetti SM, Karunanayake L, Premawansa S. Adjuvant effect of combined hot water extract of Coriandrum sativum L. and Coscinium fenestratum on rat antibody response against Leptospira antigens (PP3). Proceedings of 7th Annual Scientific Sessions of the IBMBB, University of Colombo. 21st May 2015; pp 31
A diagnostic model for Leptospirosis for use in resource limited settings
Rajapakse S, Weeratunga PN, Rodrigo C, Sriharan S, Niloofa MJR, Fernando N, de silva HJ, Karunanayake L, Premawansa S, Handunnetti S. A diagnostic model for Leptospirosis for use in resource limited settings (OP008). 128th Anniversary (SLMA) International Medical Congress, 6-8th July 2015; pp 120. (won the Karunadasa Rajasuriya award for Tropical Medicine)
Study on passive transfer of maternal IgG antibodies against measles, mumps and rubella from mothers to infants
Nadhikala M, Pathirana PPSL, Handunnetti SM, Peiris S, Galagoda GCS. Study on passive transfer of maternal IgG antibodies against measles, mumps and rubella from mothers to infants. Proceedings of the 34th Annual Session of the IOB-SL, 26th September 2014, Abstract no 2-14, pp 54
Preliminary results of activity guided fractionation of the ethanolic extract of dried flowers of Aegle marmelos
Kumari KDKP, Samarasinghe, Handunnetti SM, and Suresh TS. Preliminary results of activity guided fractionation of the ethanolic extract of dried flowers of Aegle marmelos (Beli mal). 1st Ruhuna International Science and Technology Conference, University of Ruhuna Matara Sri Lanka, January 2014; pp 140
Platelet cytotoxicity and serum lactate dehydrogenase levels as prognostic markers for severe dengue infections in Sri Lanka (C1)
Bandara MNS, Handunnetti SM, Premawansa G, Loeb M, De Silva AD, Premawansa S. Platelet cytotoxicity and serum lactate dehydrogenase levels as prognostic markers for severe dengue infections in Sri Lanka (C1). Proceedings of the 7th Biennial Sessions of the AISSL, 2nd September 2014, pp 29
Oxidative damage of lipids and proteins in Leptospirosis
Narmada Fernando, Niloofa MJR, Sachith Maduranga, Chathuraka Rodrigo, Lilani Karunanayake, Janaka De Silva, Senaka Rajapakse, Sunil Premawansa, Shiroma Handunnetti. Oxidative damage of lipids and proteins in Leptospirosis OP 07). 2nd ICFMLS, IBMBB, University of Colombo, 11-12th September 2014, pp 38
Maternal transfer of anti-measles antibodies to newborns of vaccinated and naturally immune mothers
Nadhikala M, Pathirana PPSL, Peiris S, Handunnetti SM, Galagoda GCS. Maternal transfer of anti-measles antibodies to newborns of vaccinated and naturally immune mothers. Proceedings of the Annual Scientific sessions, Sri Lankan Society for Microbiology. 24th October, 2014. pp 01
Lymphocyte activation and inhibition of iNOS expression by combined hot water extract of Coriandrum sativum L. and Coscinium fenestratumG
Harasgama HDAJC, Handunnetti SM, Weearasena OVDSJ, Premakumara S. Lymphocyte activation and inhibition of iNOS expression by combined hot water extract of Coriandrum sativum L. and Coscinium fenestratumG. 2nd International Conference on Ayurveda, Siddha & Traditional Medicine, Institute of Indigenous Medicine, University of Colombo, 16-18th September 2014, pp 117
Low prevalence of IgG antibodies against measles, mumps and rubella in infants between 6-12 months of age in Colombo district, Sri Lanka (C7)
Nadhikala M, Pathirana PPSL, Handunnetti SM, Peiris, S, Galagoda GCS. Low prevalence of IgG antibodies against measles, mumps and rubella in infants between 6-12 months of age in Colombo district, Sri Lanka (C7). Proceedings of the 7th Biennial Sessions of the AISSL, 2nd September 2014, pp 35
Inhibition of phagocytic and intracellular killing activity of human neutrophils by aqueous and methanolic leaf extracts of Ixora coccinea
Wickremasinghe R, Kumara RR, De Silva DE, Ratnasooriya WD, Handunnetti SM.Inhibition of phagocytic and intracellular killing activity of human neutrophils by aqueous and methanolic leaf extracts of Ixora coccinea.Journal of Ethnopharmacology, 2014;153: 900–907
nhibition of Nitric oxide production in Carrageenan induced rat peritoneal cells in vitro by Sri Lankan medicinal plant extracts
Rukshala BAD, Handunnetti SM, De Silve ED, Inhibition of Nitric oxide production in Carrageenan induced rat peritoneal cells in vitro by Sri Lankan medicinal plant extracts OP 10). 2nd ICFMLS, IBMBB, University of Colombo, 11-12th September 2014, pp 40
Inhbition of iNOS expression and enhancement of CD4 and CD40L expression by combined hot water extract of Coriandrum sativum L. and Coscinium fenestratum G
Harasgama HDAJC, Handunnetti SM, Weearasena OVDSJ, Premakumara S. Inhbition of iNOS expression and enhancement of CD4 and CD40L expression by combined hot water extract of Coriandrum sativum L. and Coscinium fenestratum G (PP 18). ICFMLS, IBMBB, University of Colombo, 11-12th September 2014, pp 56
In vitro Inhibition of rat mast cell degranulation by Sri Lankan medicinal plant extracts (B7)
Rukshala BAD, Handunnetti SM, de Silva ED. In vitro Inhibition of rat mast cell degranulation by Sri Lankan medicinal plant extracts (B7). Proceedings of the 7th Biennial Sessions of the AISSL, 2nd September 2014, pp 28
In vitro genotoxicity evaluation of Walidda antidysenterica by comet assay
Baragamaarachchi RY, Weearasena OVDSJ, Handunnetti SM, Samarasekara R. In vitro genotoxicity evaluation of Walidda antidysenterica by comet assay (PP 14). 2nd ICFMLS, IBMBB, University of Colombo, 11-12th September 2014, pp 54
Immunomodulatory activity of Link Samahan, a herbal formulation in Sri Lankan market
Ranaweera BVLR, Handunnetti SM, Weerasena OVDSJ. Immunomodulatory activity of Link Samahan, a herbal formulation in Sri Lankan market OP 09). 2nd ICFMLS, IBMBB, University of Colombo, 11-12th September 2014, pp 39
High serum lipid peroxide and low anti-oxidant capacity in leptospirosis
Narmada Fernando, Niloofa MJR, Sachith Maduranga, Lilani Karunanayake, Janaka De Silva, Senaka Rajapakse, Sunil Premawansa, Shiroma Handunnetti. High serum lipid peroxide and low anti-oxidant capacity in leptospirosis, One Health International Conference, University of Peradeniya, 6th September 2014, pp 20
Evaluation of two rapid immunodiagnostic tests, an IgM ELISA and an immunochromatography test compared to microscopic agglutination test
Niloofa MJR, Fernando TRGN, De Silva NL, Karunanayake L, Wickremesinghe H, Dikmadugoda N, Premawansa G, Wikramasinghe AR, De Silva HJ, Premawansa S, Rajapakse S, Handunnetti SM. Evaluation of two rapid immunodiagnostic tests, an IgM ELISA and an immunochromatography test compared to microscopic agglutination test (OP 06). 2nd International Conference on Frontiers in Molecular Life Sciences (ICFMLS), IBMBB, University of Colombo, 11-12th September 2014, pp 38
Evaluation of toxicity and effect on the glycogen content of liver after long term administration of water extract of dried flowers of A. marmelos in rats
Kumari KDKP, Samarasinghe, Handunnetti SM and Suresh TS. Evaluation of toxicity and effect on the glycogen content of liver after long term administration of water extract of dried flowers of A. marmelos in rats. International Conference on Multi-disciplinary Approaches, Faculty of Graduate Studies University of Sri Jayawardenepura Nugegoda, Sri Lanka, 2014; pp 37
Evaluation of Leptospirosis diagnostic tests: microscopic agglutination test, IgM based ELISA and immunochromatography test
Niloofa MJR, Fernando TRGN, De Silva NL, Karunanayake L, De Silva HJ, Premawansa S, Rajapakse S, Handunnetti SM. Evaluation of Leptospirosis diagnostic tests: microscopic agglutination test, IgM based ELISA and immunochromatography test. Proceedings of the Immunology Day Symposium 2014, Allergy and Immunology Society of Sri Lanka, 26th February, 2014, pp 07
Evaluation of IgM ELISA for diagnosis of acute leptospirosis using pathogenic Leptospiraantigens
Niloofa MJR, Karunanayake L, Wikramasinghe AR, De Silva HJ, Premawansa S, Rajapakse S, Handunnetti SM. Evaluation of IgM ELISA for diagnosis of acute leptospirosis using pathogenic Leptospiraantigens. Proceedings of the 34th Annual Session of the IOB-SL, Sri Lanka, 26th September 2014, Abstract no 18, pp 58
Establishment and validation of an in-house IgM ELISA for diagnosis of acute leptospirosis (B6)
Niloofa MJR, Karunanayake L, Wikramasinghe AR, De Silva HJ, Premawansa S, Rajapakse S, Handunnetti SM. Establishment and validation of an in-house IgM ELISA for diagnosis of acute leptospirosis (B6). Proceedings of the 7th Biannual Scientific Session of the AISSL, 2nd September 2014, pp 27
Enhancement of antigen-specific IgG production, CD40 and CD40L expression and inhibition of iNOS expression by combined hot water extract of Coriandrum sativum and Coscinium fenestratum (B3)
Harasgama HDAJC, Handunnetti SM, Weearasena OVDSJ, Premakumara S. Enhancement of antigen-specific IgG production, CD40 and CD40L expression and inhibition of iNOS expression by combined hot water extract of Coriandrum sativum and Coscinium fenestratum (B3). Proceedings of the 7th Biennial Sessions of the AISSL, 2nd September 2014, pp 24
Effect of acetone extracts of culinary mushroom Pleurotus ostreatus on carrageenan induced phagocytic cell infiltration and nitric oxide production by rat peritoneal cells
Jayasuriya WJABN, Handunnetti S, Wanigatunga A, Fernando GH, Abetunga TU and Suresh TS. Effect of acetone extracts of culinary mushroom Pleurotus ostreatus on carrageenan induced phagocytic cell infiltration and nitric oxide production by rat peritoneal cells. The 5th International Conference on Natural products for Health and Beauty, Phuket-Thailand, May 2014; pp 136
Changes in full blood count parameters leptospirosis: a prospective study
De Silva NL, Niloofa MJR, Fernando TRGN, Karunanayake L, Rodrigo C, de Silva HJ, Premawansa S, Handunnetti SM, Rajapaksa S. Changes in full blood count parameters leptospirosis: a prospective study. International Archives of Medicine, 2014, 7:31 doi: 10.1186/1755-7682-7-31
Biomarkers of oxidative stress in severe leptospirosis (C6)
Fernando N, Wickramasinghe S, Karunanayake L, De Silva HJ, Premawansa S, Rajapakse S, Handunnetti SM, Biomarkers of oxidative stress in severe leptospirosis (C6). Proceedings of the 7th Biennial Sessions of the AISSL, 2nd September 2014, pp 34
Association between antibody-mediated platelet destruction and the severity of dengue infections in Sri Lanka
Bandara M, Handunnetti SM, Premawansa G, De Silva AD, Premawansa S. Association between antibody-mediated platelet destruction and the severity of dengue infections in Sri Lanka (PP 05). 2nd International Conference on Frontiers in Molecular Life Sciences (ICFMLS), Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo11-12th September 2014, pp 50
Antioxidant activity and total pPolyphenolic content of weedy herb Commelina diffusa
Perera HDSM, Samarasekera R, Handunnetti SM, Weerasena OVDSJ. Antioxidant activity and total pPolyphenolic content of weedy herb Commelina diffusa (PP 15). 2nd ICFMLS, IBMBB, University of Colombo, 11-12th September 2014, pp 55
Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats
Kumari KDKP, Weerakoon TCS, Handunnetti SM, Samarasinghe K, Suresh TS. Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats. Journal of Ethnopharmacology, 2014:151:1202-1208
Acetylcholinesterase inhibitory and anti-oxidant activities of leaves of Toona ciliata
Samaradivakara SP, Samarasekera R, Handunnetti SM, Weerasena OVDSJ. Acetylcholinesterase inhibitory and anti-oxidant activities of leaves of Toona ciliata (PP 16). 2nd ICFMLS, IBMBB, University of Colombo, 11-12th September 2014, pp 55