Professor Shiroma M Handunnetti
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
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Altered Reactive Nitrogen Species production, NF-κB expression in phagocytes and severity of severe leptospirosis infections
Shiroma Handunnetti, Narmada Fernando, Sanjika Milhani, Daniya Edward, Lilani Karunanayake, Sunil Premawansa, Senaka Rajapakse. Altered Reactive Nitrogen Species production, NF-κB expression in phagocytes and severity of severe leptospirosis infections, 10th International Leptospirosis Society Scientific Meeting, Palmerston, New Zealand, 27th Nov-1stDec 2017; pp 247
Synthesis and characterization of novel Rhenium (I) complexes towards potential biological imaging applications
Kokila Ranasinghe, Shiroma Handunetti, Inoka C Perera, Theshini Perera. Synthesis and characterization of novel Rhenium (I) complexes towards potential biological imaging applications. Chemistry Central Journal. 2016; 10(1). DOI: 10.1186/s13065-016-0218-4
Sri Lankan CVID population displays a higher prevalence of TNFRSF13B gene variation. (OP-C5)
Sathkumara HD, De Silva AD, Handunnetti SM, De Silva, NR. Sri Lankan CVID population displays a higher prevalence of TNFRSF13B gene variation. (OP-C5). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 34
Serovar diversity of pathogenic Leptospira infecting patients in Western Province, Sri Lanka. (OP-B3)
Niloofa R, Karunanayake L, Premawansa S, Rajapakse S, Handunnetti SM. Serovar diversity of pathogenic Leptospira infecting patients in Western Province, Sri Lanka. (OP-B3). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 25
Role of Human Neutrophils in Inflammation and it’s Modulation by Ixora coccinea
Rachitha Wickremesinghe, Shiroma Handunnetti. Role of Human Neutrophils in Inflammation and it’s Modulation by Ixora coccinea. Research and Reviews: A Journal of Immunology, 2016; 6(1):32-48
R3 Mutational analysis of B cell activating factor receptor (BAFF-R) and inducible costimulator (ICOS) in patients with common variable immunodeficiency (CVID) in Sri Lanka
Gayathri K, Weeraman CPK, Sathkumara HD, Handunnetti SM, De Silva AD, De Silva R3 Mutational analysis of B cell activating factor receptor (BAFF-R) and inducible costimulator (ICOS) in patients with common variable immunodeficiency (CVID) in Sri Lanka. (PP7). Proceedings of the 8h Annual Scientific Sessions of the IBMBB, University of Colombo. 27th May 2016, pp: 35
Protein carbonyl as a biomarker of oxidative stress in severe leptospirosis, and its usefulness in differentiating leptospirosis from dengue infections
Narmada Fernando, Shalini Wickramasinghe, Roshan Niloofa, Chathuraka Rodrigo, Lilani Karunanayake, H Janaka de Silva, Rajitha Wickramasinghe, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti. Protein carbonyl as a biomarker of oxidative stress in severe leptospirosis, and its usefulness in differentiating leptospirosis from dengue infections. PLoS ONE. 2016; 11(6): e0156085. doi:10.1371/journal. pone.0156085
Protein carbonyl as a biomarker of oxidative stress for differentiating critical phase dengue infections from severe leptospirosis
Narmada Fernando, Shalini Wickramasinghe, Roshan Niloofa, Chathuraka Rodrigo, Lilani Karunanayake, H Janaka de Silva, Rajitha Wickramasinghe, Sunil Premawansa, Senaka Rajapakse, Shiroma Handunnetti. Protein carbonyl as a biomarker of oxidative stress for differentiating critical phase dengue infections from severe leptospirosis. 2016. The NSF Research Summit
Preliminary Studies on Activity Guided Fractionation of the Ethanolic Extract of Dried Flowers of Aegle Marmelos
Kumari KDKP, Samarasinghe K, Handunnetti SM, Suresh TS. Preliminary Studies on Activity Guided Fractionation of the Ethanolic Extract of Dried Flowers of Aegle Marmelos. International Journal of Green and Herbal Chemistry. 2016; 5(2): 122-138
Mutational analysis of B cell activating factor receptor (BAFF-R) and inducible co-stimulator (ICOS) in patients with common variable immunodeficiency (CVID) in Sri Lanka. (OP-B4)
Gayathri K, Weeraman CPK, Sathkumara HD, Handunnetti S, De Silva AD, de Silva R. Mutational analysis of B cell activating factor receptor (BAFF-R) and inducible co-stimulator (ICOS) in patients with common variable immunodeficiency (CVID) in Sri Lanka. (OP-B4). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 26
Male infants are protected for a longer period than female infants by maternally transferred antibodies against measles in Sri Lanka. (OP-C2)
Nadhikala M, Pathirana PPSL, Periris S, Handunnetti SM, Galgada GCS. Male infants are protected for a longer period than female infants by maternally transferred antibodies against measles in Sri Lanka. (OP-C2). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 31
Lethal and sub-lethal effects on the Asian common toad Duttaphrynus melanostictus from hexavalent chromium
Vindhya A.K. Fernando, Jagath Weerasena , Inoka C. Perera , Chandima D. Dangalle , Shiroma Handunnetti, Sunil Premawansa Mayuri R. Wijesinghe. Lethal and sub-lethal effects on the Asian common toad Duttaphrynus melanostictus from hexavalent chromium. Aquatic Toxicology, 2016; 177:98-105. May 2016, DOI:10.1016/j
Leptospirosis: challenges in diagnosis, and predictors of severity
Rajapakse S, Fernando N, Niloofa MJR, de Silva HJ, Karunanayake L, Premawansa S, Handunnetti SM. Leptospirosis: challenges in diagnosis, and predictors of severity [E.V. Peiris Oration 2014; Orator: Rajapakse S]. Journal of the Ceylon College of Physicians, 2016, 47:60-69
Involvement of serum antioxidants and lipid peroxides in severe dengue infection
Mapalagamage M, Handunnetti S, Premawansa G, Fernando GTG, De Silva D, Premawansa S. Involvement of serum antioxidants and lipid peroxides in severe dengue infection. (OP-B1). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 23
Increased serum nitrite levels and low serum IgM levels in severe dengue (dengue haemarrhagic fever) patients
Mapalagamage MS, Handunnetti SM, Premawansa G, Karunayokiny K, De Silva AD, Premawansa S. Increased serum nitrite levels and low serum IgM levels in severe dengue (dengue haemarrhagic fever) patients. Proceedings of the 71st Annual Sessions of the SLAAS, 2015, pp 06
In vitro anti-inflammatory and anti-oxidant activities of Sri Lankan medicinal plants
Sachindra M Perera, Radhika Samarasekera, Shiroma M Handunnetti, Jagathpriya Weerasena. In vitro anti-inflammatory and anti-oxidant activities of Sri Lankan medicinal plants. Industrial Crops and Products, 2016; 94:610-620
Immunochemical characterization of venom of medically important ants in Sri Lanka and determination of venom cross-reactivity with Western ant species
De Silva BD, Handunnetti SM, Premawansa S, Dias RKS, de Silva NR. Immunochemical characterization of venom of medically important ants in Sri Lanka and determination of venom cross-reactivity with Western ant species. (PP3). Proceedings of the 8th Annual Scientific Sessions of the IBMBB, University of Colombo. 27th May 2016, pp: 31
Effects of pathogenic Leptospira on functions and viability of vascular endothelial cells and kidney epithelial cells. (OP9)
Fernando N, Handunnetti SM, Rajapakse S, de Silva HJ, Premawansa S. Effects of pathogenic Leptospira on functions and viability of vascular endothelial cells and kidney epithelial cells. (OP9). Proceedings of the 8th Annual Scientific Sessions of IBMBB, University of Colombo. 27th May 2016, pp 20
Diagnostic accuracies of six different immunoassays compared to the gold standard tests, real-time quantitative PCR and isolation of pathogenic Leptospira. (OP8)
Niloofa MJR, Karunanayake L, De Silva HJ, Premawansa S, Rajapakse S, Handunnetti SM. Diagnostic accuracies of six different immunoassays compared to the gold standard tests, real-time quantitative PCR and isolation of pathogenic Leptospira. (OP8). Proceedings of the 8th Annual Scientific Sessions of IBMBB, University of Colombo. 27th May 2016, pp: 19
Contribution of different types of antioxidants to dengue hemorrhagic fever patients in Sri Lanka. (OP11)
Mapalagamage MS, Handunnetti SM, De Silva A, Premawansa G, Premawansa S. Contribution of different types of antioxidants to dengue hemorrhagic fever patients in Sri Lanka. (OP11). Proceedings of the 8th Annual Scientific Sessions of IBMBB, University of Colombo. 27th May 2016, pp: 22
Comparison of HPLC profiles of venom of Apis dorsata Fabricius (Giant Asian honey bee) and Apis mellifera Linnaeus (Western honey bee). (OP7)
Gunasekara DLPE, Handunnetti SM, Premawansa S, Dias RKS, Witharana EWRA, Dasanayake WMDK, Premakumara GAS and De Silva NR. Comparison of HPLC profiles of venom of Apis dorsata Fabricius (Giant Asian honey bee) and Apis mellifera Linnaeus (Western honey bee). (OP7). Proceedings of the 8th Annual Scientific Sessions of IBMBB, University of Colombo. 27th May 2016, pp: 18
Comparison of cross-reactivity of IgE antibodies with native and recombinant PLA2 (rApi m 1) of Apis mellifera Linnacus and PLA2 of Apis dorsata Fabricius. (OP-C7)
Gunasekara DLPE, Handunnetti SM, Premawansa S, Witharana EWRA, Dasanayake WMDK, Suranjith L Seneviratne, Dias RKS, Premakumara GA , De Silva NR.Comparison of cross-reactivity of IgE antibodies with native and recombinant PLA2 (rApi m 1) of Apis mellifera Linnacus and PLA2 of Apis dorsata Fabricius. (OP-C7). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 36
Community based sero-prevalence of human leptospirosis infection in the Colombo District. (OP10)
Balaji K, Karunanayake L, Handunnetti SM, Fernando SD , Rajapakse S. Community based sero-prevalence of human leptospirosis infection in the Colombo District. (OP10). Proceedings of the 8th Annual Scientific Sessions of IBMBB, University of Colombo. 27th May 2016, pp: 21
Cholinesterase, protease inhibitory and antioxidant capacities of Sri Lankan medicinal plants
Saroopa P Samaradivakara, Radhika Samarasekera, Shiroma M Handunnetti, Jagathpriya Weerasena. Cholinesterase, protease inhibitory and antioxidant capacities of Sri Lankan medicinal plants. Industrial Crops & Products, 2016; 83:227-234
C3 Characterization of allergenic venom constituents of medically important ant species in Sri Lanka and determination of venom cross-reactivity with Western ant species. (OP-C3)
De Silva BD, Handunnetti SM, Premawansa S, Dias RKS, Seneviratne SL, de Silva R. C3 Characterization of allergenic venom constituents of medically important ant species in Sri Lanka and determination of venom cross-reactivity with Western ant species. (OP-C3). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 32
assive transfer of anti -measles, -mumps and –rubella antibodies from mother to newborn in Sri Lanka. (OP-C1)
Nadhikala M, Pathirana PPSL, Periris S, Handunnetti SM, Galgada GCS. Passive transfer of anti -measles, -mumps and –rubella antibodies from mother to newborn in Sri Lanka. (OP-C1). Proceedings of the 8th Biennial Sessions of the AISSL, 15th July 2016, pp 30
A diagnostic scoring model for leptospirosis in resource limited settings - A prospective study
Senaka Rajapakse, Praveen Weeratunga, M.J. Roshan Niloofa, Narmada Fernando, Nipun Lakshitha Fernando, Chathuraka Rodrigo, SachithMaduranga, Nuwanthi nandasiri, Sunil Premawansa, H. Janaka De Silva, Lilani Karunanayake, Shiroma Handunnetti. A diagnostic scoring model for leptospirosis in resource limited settings – A prospective study. PLOS Neglected Tropical Diseases. 2016; 10 (6): e0004513. doi:10.1371/journal.pntd.0004513
Vascular endothelial cell damage by pathogenic Leptospira
Narmada Fernando, Jayamini Harasgama, Roshan Niloofa, Lilani Karunanayake, Janaka H de Silva, Senaka Rajapakse, Sunil Premawansa, Shiroma Handunnetti. Vascular endothelial cell damage by pathogenic Leptospira. iPURSE 2015, University of Peradeniya, 5-6TH November 2015, pp 339
The role of neutrophils in the interaction between pathogenic Leptospira and vascular endothelial cells
Shiroma Handunnetti, Narmada Fernando, Senaka Rajapakse, H Janaka de Silva, Sunil Premawansa, The role of neutrophils in the interaction between pathogenic Leptospira and vascular endothelial cells, 9th International Leptospirosis Society Scientific Meeting, 7-10th October 2015, Semarang, Indonesia; pp 101
Superoxide production by differentiated HL-60 cells interacted with Leptospira
Narmada Fernando, Roshan Niloofa, Lilani Karunanayake, H Janaka de Silva, Sunil Premawansa, SenakaRajapakse, Shiroma Handunnetti. Superoxide production by differentiated HL-60 cells interacted with Leptospira. 2nd ELS meeting on Leptospirosis and other rodent borne haemorrhagic fevers. 16-18th April 2015; 58