Professor Shiroma M Handunnetti
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB)
Publications
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Role of antibody response in disease severity of leptospirosis (OP11)
Roshan Niloofa, Narmada Fernando, Lilani Karunanayake, H Janaka de Silva, Sunil Premawansa, Senala Rajapakse, Shiroma Handunnetti. Role of antibody response in disease severity of leptospirosis (OP11). Proceedings of the 7th Annual Scientific Sessions of Institute of IBMBB, University of Colombo. 21st May 2015; pp 21
Recommendations to enhance reproducibility and reliability in comet assay
Baragamaarachchi RY, Weearasena OVDSJ, Handunnetti SM, Samarasekara R. Recommendations to enhance reproducibility and reliability in comet assay. 4th Global Summit on Toxicology, August 24-26, 2015, Philadelphia, USA, J Clin Toxicol, 2015, 5:3 http://dx.doi.org/10.4172/2161-0495.S1.015
Pathogenic Leptospira sppinduce higher superoxide anion production by HL 60-derived neutrophils
Fernando TRGN, Niloofa MJR, de Silva HJ, Rajapakse S, Premawansa S, Handunnetti SM, Pathogenic Leptospira sppinduce higher superoxide anion production by HL 60-derived neutrophils. Proceedings of the 71st Annual Sessions of the SLAAS, 2015, pp 52
Passive transfer and decay of maternally transferred IgG antibodies against measles, mumps and rubella in infants in Colombo district, Sri Lanka (OP12)
Nadhikala M, Pathirana PPSL, Handunnetti SM, Galagoda GCS. Passive transfer and decay of maternally transferred IgG antibodies against measles, mumps and rubella in infants in Colombo district, Sri Lanka (OP12). Proceedings of the 7th Annual Scientific Sessions of IBMBB, University of Colombo. 21st May 2015; pp 22
OUSL book Chapters: Lessons written for The Open University of Sri Lanka course books – MSc /Post Graduate Diploma in Medical Entomology and Applied Parasitology – 2015
- Lesson on “Drug Resistance” in Molecular Biology in Parasite Control module
- Three Lessons for Vaccine Development” module
- Basic Principles of Vaccination
- Whole organism Vaccines: Inactivated and live-attenuated Vaccines
- Subunit Vaccines containing Individual Protective Antigens and Production of Vaccine Antigens in Large Quantities
Leptospirosis severity association with the humoral immune response
Roshan Niloofa, Narmada Fernando, Lilani Karunanayake, H Janaka de Silva, Sunil Premawansa, SenakaRajapakse, Shiroma Handunnetti. Leptospirosis severity association with the humoral immune response. 2nd ELS meeting on Leptospirosis and other rodent borne haemorrhagic fevers. 16-18th April 2015; pp 56
Inflammatory cytokine responses in Sri Lankan patients with leptospirosis and the effect of antibiotic treatment
Narmada Fernando, Rajiva De Silva, Shiroma Handunnetti, Lilani Karunanayake, H Janaka de Silva, Senaka Rajapakse, Sunil Premawansa. Inflammatory cytokine responses in Sri Lankan patients with leptospirosis and the effect of antibiotic treatment. 9th International Leptospirosis Society (ILS) Scientific Meeting. 7-10th October 2015, Semarang, Indonesia; 42
In vitro anti-inflammatory activity of methanol/dichloromethane extract of Vernonia zeylanica (L.) Less (OP5)
Rukshala BAD, Handunnetti SM, de Silva ED. In vitro anti-inflammatory activity of methanol/dichloromethane extract of Vernonia zeylanica (L.) Less (OP5). Proceedings of the 7th Annual Scientific Sessions of IBMBB, University of Colombo. 21st May 2015; pp 15
In vitro anti arachidonate 5-lipoxygenase activity of selected Sri Lankan medicinal plants
Perera HDSM, Samarasekera R, Handunnetti S, Weerasena OVDSJ. In vitro anti arachidonate 5-lipoxygenase activity of selected Sri Lankan medicinal plants. Proceedings of the Biennial Research Symposium of the Industrial Technology Institute, 16-17th November 2015
In vitro anti 5-lipoxygenase, anti-hyaluronisade and anti-oxidant properties of ethanolic leaf extract of Diospyros ebenum
Perera HDSM, Samarasekera R, Handunnetti S, Weerasena OVDSJ. In vitro anti 5-lipoxygenase, anti-hyaluronisade and anti-oxidant properties of ethanolic leaf extract of Diospyros ebenum. Proceedings of the 35th Annual Session of the IOB-SL, Sri Lanka, 25th September 2015, Abstract no 3-12, pp 61
Immunochemical characterization of venom of Apis dorsata Fabricius (Bambara) in Sri Lanka (Hymenoptera; Apidae)
Gunasekara DLPE, De Silva NR, Handunnetti SM, Dias RKS, Witharana EWRA, Dasanayake WMDK, Premawansa S. Immunochemical characterization of venom of Apis dorsata Fabricius (Bambara) in Sri Lanka (Hymenoptera; Apidae) (PP1). Proceedings of 7th Annual Scientific Sessions of the IBMBB, University of Colombo. 21st May 2015; pp 28
Genetics of common variable immunodeficiency: role of transmembrane activator and calcium-modulator and cyclophilin ligand interactor
Sathkumara H, De Silva AD, De Silva NR, Handunnetti S. Genetics of common variable immunodeficiency: role of transmembrane activator and calcium-modulator and cyclophilin ligand interactor. International Journal of Immunogenetics. 2015 (19 JUN), DOI: 10.1111/iji.12217
Genetics of common variable immunodeficiency (CVID): Role of transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI)
Sathkumara SMHD, De Silva NR, Handunnetti SM, De Silva AD. Genetics of common variable immunodeficiency (CVID): Role of transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) (PP2). Proceedings of 7th Annual Scientific Sessions of the IBMBB, University of Colombo. 21st May 2015; pp 29
Extracts of Alpiniacalcarata (Lessor Galanga) inhibits production of inflammatory mediator-nitric oxide in RAW 264.7 murine macrophages
Chandrakanthan M, Kathiragamanthar S, Handunnetti SM and Premakumar GAS. Extracts of Alpiniacalcarata (Lessor Galanga) inhibits production of inflammatory mediator-nitric oxide in RAW 264.7 murine macrophages. Proceedings of The Young Scientists Forum, 23rd January 2015. pp 27-40
Evaluation of two immunodiagnostic tests for early rapid diagnosis of leptospirosis in Sri Lanka: a preliminary study
Eugene EJ, Handunnetti SM, Wickramasinghe SA, Kalugalage TL, Rodrigo C, Wickramasinghe H, Dikmadugoda N, Somaratne P, de Silva HJ and Rajapakse S. Evaluation of two immunodiagnostic tests for early rapid diagnosis of leptospirosis in Sri Lanka: a preliminary study. BMC Infectious Diseases. 2015; 15:319 DOI 10.1186/s12879-015-1080
Evaluation of anti-inflammatory activity of Alpinia calcarata leaf extracts: An in vitro study (OP6)
Chandhrakanthan M, Kathirgamanathar S, Handunnetti SM, Premakumara GAS. Evaluation of anti-inflammatory activity of Alpinia calcarata leaf extracts: An in vitro study (OP6). Proceedings of the 7th Annual Scientific Sessions of IBMBB, University of Colombo. 21st May 2015; pp 16
Essential oils of Alpinia calcarata Rosc. inhibits the in vitro generation of reactive oxygen species in mouse macrophages
M Chandhrakanthan, S Kathirgamanathar, SM Handunnetti, GAS Premakumara. Essential oils of Alpinia calcarata Rosc. inhibits the in vitro generation of reactive oxygen species in mouse macrophages. Proceedings of 2nd International Conference on Multi disciplinary Approaches-ICMA; 12th September 2015
Do antibodies play a role in ROS production by HL 60-derived neutrophils against Leptospira? (OP8)
Fernando TRGN, Niloofa R, Karunanayake L, de Silva HJ, Rajapakse S, Premawansa S, Handunnetti SM. Do antibodies play a role in ROS production by HL 60-derived neutrophils against Leptospira? (OP8). Proceedings of the 7th Annual Scientific Sessions of IBMBB, University of Colombo. 21st May 2015; pp 18
Differentiation of severe leptospirosis from critical phase dengue infections
Narmada Fernando, Roshan Niloofa, Lilani Karunanayake, H Janaka de Silva, Sunil Premawansa, SenakaRajapakse, Shiroma Handunnetti. Differentiation of severe leptospirosis from critical phase dengue infections. 2nd European Leptospirosis Society (ELS) meeting on Leptospirosis and other rodent borne haemorrhagic fevers. 16-18th April 2015; pp 14
Diagnosis of Leptospirosis: Comparison between Microscopic Agglutination Test, IgM-ELISA and IgM Rapid Immunochromatography Test
Niloofa R, Fernando N, de Silva NL, Karunanayake L, Wickramasinghe H, Dikmadugoda N, Premawansa G, Wickramasinghe R, de Silva HJ, Premawansa S, Rajapakse S, Handunnetti S. (2015) Diagnosis of Leptospirosis: Comparison between Microscopic Agglutination Test, IgM-ELISA and IgM Rapid Immunochromatography Test. PLoS ONE. 2015 Jun 18; 10(6): e0129236. doi: 10.1371/ journal.pone.0129236
Degree of maternal transfer of antibodies against measles, mumps and Rubella to newborns of pre- and post-vaccination era mothers
Nadikala M, Pathirana PPSL, Peiris S, Handunnetti SM, Galagoda GCS. Degree of maternal transfer of antibodies against measles, mumps and Rubella to newborns of pre- and post-vaccination era mothers. Proceedings of The Young Scientists Forum, 23rd January 2015. pp 128-131
Defining coagulation dysfunctionin patients with leptospirosis
Rasa Threeswaran, Lallindra Gooneratne, Shiroma Handunnetti, Roopen Arya, Senaka Rajapakse. Defining coagulation dysfunctionin patients with leptospirosis (ABS-3413). Proceedings of the International Society on Thrombosis and Haemostasis (ISTH 2015), Toronto 20-25th June 2015
Cytotoxic and genotoxic potential of Walidda antidysenterica on human lymphocytes- A herb used in Sri Lankan traditional medicine
Baragamaarachchi RY, Weearasena OVDSJ, Handunnetti SM, Samarasekara R. Cytotoxic and genotoxic potential of Walidda antidysenterica on human lymphocytes- A herb used in Sri Lankan traditional medicine. 4th Global Summit on Toxicology, August 24-26, 2015 Philadelphia, USA, J Clin Toxicol, 2015, 5:3 http://dx.doi.org/10.4172/2161-0495.S1.015
Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity
Rajapakse S, Rodrigo C, Handunnetti SM, Fernando SD. Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity. Annals of Clinical Microbiology and Antimicrobials. 2015 Jan 16; 14:2. doi: 10.1186/s12941-014-0060-2DOI 10.1186/s12941-014-0060-2
Clinico-epidemiological characteristics, treatment and outcomes of patients with confirmed leptopsirosis in a Sri Lankan healthcare setting
Rajapakse S, Weeratunga PN, Rodrigo C, Sriharan S, Niloofa MJR, Fernando N, de silva HJ, Karunanayake L, Premawansa S, Handunnetti S. Clinico-epidemiological characteristics, treatment and outcomes of patients with confirmed leptopsirosis in a Sri Lankan healthcare setting. (OP009). 128th Anniversary (SLMA) International Medical Congress, 6-8th July 2015, pp 120-121
Clinical and laboratory associations of severityin a Sri Lankan cohort of patients with serologically confirmed Leptospirosis - a prospective study
Rajapakse S, Weeratuna PN, Rodrigo C, Sriharan S, Niloofa MJR, Fernando N, de silva HJ, Karunanayake L, Premawansa S, Handunnetti S. Clinical and laboratory associations of severityin a Sri Lankan cohort of patients with serologically confirmed Leptospirosis – a prospective study (OP007). 128th Anniversary (SLMA) International Medical Congress, 6-8th July 2015, pp 119-120
Clinical and laboratory associations of severity in a Sri Lankan cohort of patients with serologically confirmed leptospirosis – A prospective study
Senaka Rajapakse, Praveen Weeratunga, M.J. Roshan Niloofa, Narmada Fernando, Chathuraka Rodrigo, SachithMaduranga, NipunLakshitha Fernando, H. Janaka De Silva, Lilani Karunanayake, Shiroma Handunnetti. Clinical and laboratory associations of severity in a Sri Lankan cohort of patients with serologically confirmed leptospirosis – A prospective study. Transactions of Royal Society of Tropical Medicine Hygiene. 2015; 109 (11): 710-716
Changes in serum nitrite and nitrate in dengue and dengue haemarrhagic fever
Maheshi Mapalgamage, Handunnetti SM, Premawansa G, Sharmila Thilainathan, De Silva AD, Premawansa S Changes in serum nitrite and nitrate in dengue and dengue haemarrhagic fever, iPURSE 2015, University of Peradeniya, 5-6TH November 2015, pp 228
Anti-inflammatory volatile constituents from rhizomes and leaves of Alpinia calcarata
M Chandhrakanthan, S Kathirgamanathar, SM Handunnetti, GAS Premakumara. Anti-inflammatory volatile constituents from rhizomes and leaves of Alpinia calcarata. Proceedings of the Biennial Research Symposium of the Industrial Technology Institute, 16-17th November 2015
Anti-inflammatory activity of hot water infusion of Nyctanthus arbotristis flowers
Ratnasooriya WD, Jayakody J, Handunnetti SM, Ratnasooriya C, Weerasekera KR. Anti-inflammatory activity of hot water infusion of Nyctanthus arbotristis flowers. Indian Journal of Pharmaceutical Science. 2015; 77:613-9